教育背景
PhD, Indian Institute of Science, 2015
实验室信息
Alan Hinnebusch's Lab
研究方向
Cellular stress response, ribosome stalling and collisions, metabolic homeostasis, tRNA modifications, nutrient starvation, yeast biology, metabolism, cell signaling, starvation, sporulation, budding yeast, metabolites, mRNA translation, ribosomes, ribosomal P stalk proteins, CRISPR-Cas9, GAAC signaling, Integrated stress response, ribosome profiling
发表论文
https://scholar.google.com/citations?user=kHxQx0gAAAAJ&hl=en&authuser=11. Gupta R and Hinnebusch A. Differential requirements for P-stalk components in activating yeast protein kinase Gcn2 by stalled ribosomes during stress. PNAS 2023; 10.1073/pnas.2300521120.1.
2. Gupta R and Laxman S. Cycles, sources and sinks: Conceptualizing how phosphate balance modulates carbon flux using yeast metabolic networks. as central metabolic regulators. eLIFE 2021;
10:e63341.
3. Walvekar A#, Kadamur G#, Sreedharan S, Gupta R, Srinivasan R and Laxman S. Methylated PP2A stabilizes Gcn4 to enable a methionine-induced anabolic program. JBC 2020; Oct 29, doi:10.1074/
jbc.RA120.014248.
4. Gupta R# and Laxman S#. Steady-state and flux-based trehalose estimation as an indicator of carbon flow from gluconeogenesis or glycolysis. Bioprotocols 2020; 10(1): e3483.
#co-corresponding authors
5. Gupta R and Laxman S. tRNA wobble-uridine modifications as amino acid sensors and regulators of cellular metabolic state. Current Genetics 2019, 66, 475–480.
6. Gupta R, Walvekar A, Liang S, Rashida Z, Shah P, Laxman S. A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis. eLIFE 2019; 8:e44795.
7. Walvekar A, Srinivasan R, Gupta R, Laxman S. Methionine coordinates a hierarchically organized anabolic program enabling proliferation. MBoC 2018, Vol. 29, No. 26.
8. Gupta R, Sadhale PP, Vijayraghavan U. SUB1 plays a negative role during starvation induced sporulation program in Saccharomyces cerevisiae. PLoS ONE 2015;10(7):e0132350.
9. Gupta R#, Adhikary S#, Dalpatraj N, Laxman S. An economic demand-based framework for prioritization strategies in response to transient amino acid limitations. Nat Comm 2024; 15, 7254.
#equal contribution