教育背景
PhD, Indian Institute of Science, 2015
实验室信息
Alan Hinnebusch's Lab
https://annualreport.nichd.nih.gov/hinnebusch.html
研究方向
Cellular stress response, ribosome stalling and collisions, metabolic homeostasis, tRNA modifications, nutrient starvation, yeast biology, metabolism, cell signaling, starvation, sporulation, budding yeast, metabolites, mRNA translation, ribosomes, ribosomal P stalk proteins, CRISPR-Cas9, GAAC signaling, Integrated stress response, ribosome profiling
发表论文
https://scholar.google.com/citations?user=kHxQx0gAAAAJ&hl=en&authuser=11. Gupta R, Gaikwad S, Qui H, Bou-Nader C, Zhang J, Hinnebusch A. Purification and Analysis of eIF2α Phosphorylation by Stress-Activated Protein Kinase Gcn2 from S. cerevisiae. In: Russell, F.M., Hardie, D.G. (eds) Nutrient Sensing in Eukaryotes. Methods in Molecular Biology, 2025, vol 2882.
2. Gupta R#, Adhikary S#, Dalpatraj N, Laxman S. An economic demand-based framework for prioritization strategies in response to transient amino acid limitations. Nat Comm 2024; 15, 7254.
#equal contribution
3. Gupta R and Hinnebusch A. Differential requirements for P-stalk components in activating yeast protein kinase Gcn2 by stalled ribosomes during stress. PNAS 2023; 10.1073/pnas.2300521120.1.
4. Gupta R and Laxman S. Cycles, sources and sinks: Conceptualizing how phosphate balance modulates carbon flux using yeast metabolic networks. as central metabolic regulators. eLIFE 2021;
10:e63341.
5. Walvekar A#, Kadamur G#, Sreedharan S, Gupta R, Srinivasan R and Laxman S. Methylated PP2A stabilizes Gcn4 to enable a methionine-induced anabolic program. JBC 2020; Oct 29, doi:10.1074/
jbc.RA120.014248.
6. Gupta R# and Laxman S#. Steady-state and flux-based trehalose estimation as an indicator of carbon flow from gluconeogenesis or glycolysis. Bioprotocols 2020; 10(1): e3483.
#co-corresponding authors
7. Gupta R and Laxman S. tRNA wobble-uridine modifications as amino acid sensors and regulators of cellular metabolic state. Current Genetics 2019, 66, 475–480.
8. Gupta R, Walvekar A, Liang S, Rashida Z, Shah P, Laxman S. A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis. eLIFE 2019; 8:e44795.
9. Walvekar A, Srinivasan R, Gupta R, Laxman S. Methionine coordinates a hierarchically organized anabolic program enabling proliferation. MBoC 2018, Vol. 29, No. 26.
10. Gupta R, Sadhale PP, Vijayraghavan U. SUB1 plays a negative role during starvation induced sporulation program in Saccharomyces cerevisiae. PLoS ONE 2015;10(7):e0132350.