MAJOR PUBLICATIONS FROM LAST 5 YEARS
1. Giannetto MJ, Gomolka RS, Gahn-Martinez D, Newbold EJ, Bork PAR, Chang E, Gresser M, Thompson T, Mori Y, Nedergaard M. Glymphatic fluid transport is suppressed by the aquaporin-4 inhibitor AER-271. Glia 2024; 72: 982-98. doi: 10.1002/glia.24515.

Original research paper. Evaluation of novel Aqp-4 channel blocker as a promising therapeutic approach for reduction brain edema in acute pathophysiological conditions.

Role: conceptualization, noninvasive MRI protocols for DWI in-vivo, nonlinear analysis of physiological signals, formal analysis, validation, investigation, visualization, methodology, writing - original draft, writing - review end editing.
2. Gomolka RS, Hablitz L, Mestre H, Giannetto M, Du T, Hauglund NL, Xie L, Peng W, Martinez PM, Nedergaard M, Mori Y. Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation. eLife 2023; 12: e82232. doi: 10.7554/eLife.82232

Original research paper. A comprehensive summary of the developed at Panum MRI Core noninvasive MRI protocols, and own design of image analysis algorithms for a detailed, and to date non-existing evaluation of the brain morphometry in mice lacking the main water channel AQP4.

Role: conceptualization, software development, formal analysis, validation, investigation, visualization, methodology, writing - original draft, writing - review end editing.
+ Conference presentation on the topic awarded with the Best Abstract Award at ESMRMB 2023.

3. Møllgård K, Beinlich FRM, Kusk P, Miyakoshi LM, Delle C, Plá V, Hauglund NL, Esmail T, Rasmussen MK, Gomolka RS, Mori Y, Nedergaard M. A mesothelium divides the subarachnoid space into functional compartments. Science 2023; 379: 84-8. doi: 10.1126/science.adc8810

Original research paper. The first paper to describe the functional role of the fourth brain membrane, and that received a great attention in publicity. The paper allowed drawing conclusions and further research plans for the membrane’s role in the concept of drug delivery into the brain.

Role: formal analysis, investigation, writing - original draft, review and editing.

4. Delle C, Wang X, Giannetto M, Newbold E, Peng W, Gomolka RS, Ladrón-de-Guevara A, Cankar N, Schiøler Nielsen E, Kjaerby C, Weikop P, Mori Y, Nedergaard M. Transient but not chronic hyperglycemia accelerates ocular glymphatic transport. Fluids Barriers CNS 2024; 21: 26. doi: 10.1186/s12987-024-00524-w.

Role: in vivo and ex vivo MRI protocols, validation, investigation, methodology, writing - review end editing.

5. Mathiesen BK, Miyakoshi LM, Cederroth CR, Tserga E, Versteegh C, Bork PAR, Hauglund NL, Gomolka RS, Mori Y, Edvall NK, Rouse S, Møllgård K, Holt JR, Nedergaard M, Canlon B. Delivery of gene therapy through a cerebrospinal fluid conduit to rescue hearing in adult mice. Sci Transl Med 2023; 15: eabq3916.
doi: 10.1126/scitranslmed.abq3916

Role: MRI/µCT protocol setting, support in acquisition of final data and in formal analysis, review and editing.

6. Stanton EH, Persson NDÅ, Gomolka RS, Lilius T, Sigurðsson B, Lee H, Ribeiro Xavier AL, Benveniste
H, Nedergaard M, Mori Y. Mapping of CSF transport using high spatiotemporal resolution dynamic
Contrast-enhanced MRI in mice: Effect of anesthesia. Magn Reson Med 2021; 85: 3326-42. doi: 10.1002/mrm.28645

Original research paper. The paper was the first to compare the MRI tracer flow within paravascular brain compartment of mice under two anesthetic regimes, using a whole brain assessment with ultra-high resolution. Result of direct supervision of two MSc students, who were acknowledged as the first authors.

Role: data acquisition, processing and analysis, statistics and interpretation, manuscript writing.

7. Gomolka RS#, Ciritsis A, Rossi C. 23Na-T1 quantification with saturation recovery TrueFISP and variable flip angle GRE at 3T: A phantom study. Magn Reson Med 2020; 84: 3300-7. doi: 10.1002/mrm.28333

The paper describes continuation of validating the borders of clinical sodium-MRI setup usability in wide-bore general purpose clinical scanner. Part of sodium-MRI project during the Hypertension Research Network (HYRENE) collaborative grant at the University Hospital Zurich.

Role: #Corresponding author; study design, data acquisition, processing and analysis, manuscript writing.

8. Shmid FA, Poyet C, Rizzi G, Gomolka R, Donati O, Hotker A, Eberli D. Dynamic Contrast Enhancement in Prostate MRI as Predictor of Erectile Function and Recovery after Radical Prostatectomy. Aging Male 2020; 23: 1518-26. doi: 10.1080/13685538.2020.1815695

This paper is a result of my support to supervision of MD-PhD student in Zurich, and is a basis for methodology used in a further clinical trial at the University Hospital Zurich.

Role: MRI protocol design and implementation, data analysis, manuscript writing.

9. Shmid FA*, Gomolka RS*, Hotker AM, Boss A, Kessler TM, Rossi C, Eberli D. Evaluation of Urinary Sphincter Function by rapid MR Diffusion Tensor Imaging. INJ 2020; 24: 349–57. doi: 10.5213/inj.2040208.104

*Equal contribution from both authors.
This paper is a result of my support to supervision of MD-PhD student in Zurich, resulting in development of DTI imaging protocol currently used in a clinical trial at University Hospital Zurich.

Role: study design, data acquisition, processing and analysis, manuscript writing.

10. Gomolka RS#, Ciritsis A, Meier A, Rossi C. Quantification of sodium T1 in abdominal tissues at 3 T. MAGMA. 2020; 33: 439-46. doi: 10.1007/s10334-019-00786-8.

This paper was acknowledged with ESMRMB 2019 Young Investigator Award - 2nd place. This was a major personal award at the sodium-MRI project as showed a feasibility for in vivo multinuclear MRI using clinical wide-bore general purpose MR scanner.

Role: #Corresponding author; study design, data acquisition, processing and analysis, manuscript writing.

REMAINING ORIGINAL RESEARCH PAPERS:
11. Gomolka RS, Kampusch S, Kaniusas E, Thürk F, Széles JC, Klonowski W. Higuchi Fractal Dimension of Heart Rate Variability During Percutaneous Auricular Vagus Nerve Stimulation in Healthy and Diabetic Subjects. Front Physiol 2018; 9: 1162. doi: 10.3389/fphys.2018.01162.

This paper is a result of the COST BM1309 Short Term Scientific Mission grant for collaborative research in the Institute of Electrodynamics, Microwave and Circuit Engineering Technische Universität Wien, Austria. The method for analysis was intended to be applied in a feedback loop controlling the designed at the Institute auricular vagus nerve stimulation device.

Role: study design, data processing and analysis, manuscript writing.
12. Liska A, Bertero A, Gomolka R, Sabbioni M, Galbusera A, Panzeri S, Scattoni ML, Gozzi A. Homozygous loss of autism-risk gene CNTNAP2 results in reduced local and long-range prefrontal functional connectivity. Cereb Cortex 2018; 28(4): 1141-1153. doi: 10.1093/cercor/bhx022.

Role: data processing and analysis, manuscript editorial.
13. Kemėšienė J, Rühle A, Gomolka R, Wurnig MC, Rossi C, Boss A. Advanced diffusion imaging of abdominal organs in different hydration states of the human body: stability of biomarkers. Heliyon 2021; 7(1): e06072. doi: 10.1016/j.heliyon.2021.e06072

Role: data acquisition, processing and analysis, statistics and interpretation, manuscript writing.

14. Gomolka RS*#, Korzynska A*, Siemion K, Gabor-Siatkowska K, Klonowski W. Automatic method for assessement of proliferation index in digital images of DLBCL tissue section. Biocybern Biomed Eng. 2019; 39(1): 30-37. doi: 10.1016/j.bbe.2018.09.004.
*Equal contribution from both authors.

Role: #Corresponding author; study design, data analysis, manuscript writing.

15. Klonowski W, Korzynska A, Gomolka R. Computer analysis of histopathological images for tumor grading. Physiol Meas 2018; 39(3): 034002.

Role: data processing and analysis, manuscript editorial.

16. Gomolka RS, Chrzan RM, Urbanik A, Kazmierski R, Grzanka AD, Nowinski WL. Quantification of image contrast on computed tomography scans. Neuroradiol J 2017; 30(1): 15-22.

Role: data processing and analysis, manuscript writing.

This paper is a results of *Star Research Attachment Award of the author, for 21 months stay in Singapore Bioimaging Consortium, A*STAR.

17. Gomolka RS#, Chrzan RM, Urbanik A, Nowinski WL. A Quantitative Method Using Head Noncontrast CT Scans to Detect Hyperacute Nonvisible Ischemic Changes in Patients With Stroke. J Neuroimaging 2016; 26(6): 581-7.

Role: #Corresponding author; study design, data processing and analysis, manuscript writing.

This paper is a results of *Star Research Attachment Award of the author, for 21 months stay in Singapore Bioimaging Consortium, A*STAR.

18. Czarzasta K, Cudnoch-Jedrzejewska A, Szczepanska-Sadowska E, Fus L , Puchalska L, Gondek A, Dobruch J, Gomolka R, Wrzesien R, Zera T, Gornicka B, Kuch M. The role of apelin in central cardiovascular regulation in rats with post-infarct heart failure maintained on a normal fat or high fat diet. Clin Exp Pharmacol Physiol. 2016; 43(10): 983-94.

Role: experimental and surgical procedures, data acquisition.

19. Gomolka RS, Cudnoch-Jedrzejewska A, Czarzasta K, Szczepanska-Sadowska E. Reduction of pressor response to stress by centrally acting apelin in spontaneously hypertensive rats. Basic Clin Physiol Pharmacol 2015; 26(3): 233-6.

Role: study design, experimental and surgical procedures, data acquisition, processing and analysis, writing.
20. Cudnoch-Jedrzejewska A, Gomolka R, Czarzasta K, Wrzesien R, Koperski L, Puchalska L, Wsol A, Szczepanska-Sadowska E. High fat diet and chronic stress reduce central pressor and tachycardic effects of apelin in Sprague Dawley rats. Clin Exp Pharm Physiol 2015; 42(1): 52-62.

Role: study design, experimental and surgical procedures, data acquisition, processing and analysis, writing.
21. Nowinski WL, Gomolka RS, Qian GY, Gupta V, Ullman NL, Hanley DF. Characterization of intraventricular and intracerebral hematomas in noncontrast CT. Neuroradiol J 2014; 27(3): 299-315.

Role: data processing and analysis, manuscript editorial.

This paper is a results of *Star Research Attachment Award of the author, for 21 months stay in Singapore Bioimaging Consortium, A*STAR.
22. Cudnoch-Jedrzejewska A, Szczepanska-Sadowska E, Dobruch J, Gomolka R, Puchalska L. Brain vasopressin V(1) receptors contribute to enhanced cardiovascular responses to acute stress in chronically stressed rats and rats with myocardial infarction. Am J Physiol Regul Integr Comp Physiol 2010; 298(3): R672-80.

Role: surgical procedures, data acquisition, manuscript editorial.

REVIEW PAPERS:

23. Cudnoch-Jędrzejewska A, Czarzasta K, Gomółka R, Szczepańska-Sadowska E. The role of apelin in pathogenesis of cardiovascular diseases and metabolic disorders. Kardiol Pol. 2011; 69(3): 89-93. [in Polish].

Role: manuscript editorial – review article.
24. Cedro T, Frączek J, Gomółka R, Stasiuk M, Leszek G, Łącka H, Małkiewicz A, Czerniak M, Byszuk A, Adamski M, Rychter A, Demidowicz P. System do prowadzenia terapii neurofeedback. Scientific Activity 2010. Works of Students Scientific Research Groups of Faculty of Electronics and Information Technology of Warsaw Technical University (WUT). [Ed.] Prof. Andrzej Jakubiak. Publishing House of WUT 2010: 163-192. [in Polish].

Role: design, writing, review.