Improve Research Reproducibility A Bio-protocol resource
EN

DK
Daniel Krappmann
  • Faculty, Molecular Targets and Therapies Center (MTTC) Munich
研究方向
  • Cancer Biology
个人信息

Education

Ph.D. in Biology, at the Faculty of Biology, Free University Berlin, Germany

Current position

Head of the Research Unit Cellular Signal Integration at the Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

Publications

Original articles

  1. Keusekotten, K., Elliott, P. R., Glockner, L., Fiil, B. K., Damgaard, R. B., Kulathu, Y., Wauer, T., Hospenthal, M. K., Gyrd-Hansen, M., Krappmann, D., Hofmann, K. and Komander, D. (2013). OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing Met1-Linked Polyubiquitin. Cell 153(6): 1312-1326.
  2. Schulz, S., Schmitt, S., Wimmer, R., Aichler, M., Eisenhofer, S., Lichtmannegger, J., Eberhagen, C., Artmann, R., Tookos, F., Walch, A., Krappmann, D., Brenner, C., Rust, C. and Zischka, H. (2013). Progressive stages of mitochondrial destruction caused by cell toxic bile salts. Biochim Biophys Acta 1828(9): 2121-2133.
  3. Muller-Rischart, A. K., Pilsl, A., Beaudette, P., Patra, M., Hadian, K., Funke, M., Peis, R., Deinlein, A., Schweimer, C., Kuhn, P. H., Lichtenthaler, S. F., Motori, E., Hrelia, S., Wurst, W., Trumbach, D., Langer, T., Krappmann, D., Dittmar, G., Tatzelt, J. and Winklhofer, K. F. (2013). The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO. Mol Cell 49(5): 908-921.
  4. Nagel, D., Spranger, S., Vincendeau, M., Grau, M., Raffegerst, S., Kloo, B., Hlahla, D., Neuenschwander, M., Peter von Kries, J., Hadian, K., Dorken, B., Lenz, P., Lenz, G., Schendel, D. J. and Krappmann, D. (2012). Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL. Cancer Cell 22(6): 825-837.
  5. Chu, Y., Soberon, V., Glockner, L., Beyaert, R., Massoumi, R., van Loo, G., Krappmann, D. and Schmidt-Supprian, M. (2012). A20 and CYLD do not share significant overlapping functions during B cell development and activation. J Immunol 189(9): 4437-4443.
  6. Van Campenhout, C. A., Eitelhuber, A., Gloeckner, C. J., Giallonardo, P., Gegg, M., Oller, H., Grant, S. G., Krappmann, D., Ueffing, M. and Lickert, H. (2011). Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases. Dev Cell 21(3): 479-491.
  7. Hadian, K., Griesbach, R. A., Dornauer, S., Wanger, T. M., Nagel, D., Metlitzky, M., Beisker, W., Schmidt-Supprian, M. and Krappmann, D. (2011). NF-kappaB essential modulator (NEMO) interaction with linear and lys-63 ubiquitin chains contributes to NF-kappaB activation. J Biol Chem 286(29): 26107-26117.
  8. Palkowitsch, L., Marienfeld, U., Brunner, C., Eitelhuber, A., Krappmann, D. and Marienfeld, R. B. (2011). The Ca2+-dependent phosphatase calcineurin controls the formation of the Carma1-Bcl10-Malt1 complex during T cell receptor-induced NF-kappaB activation. J Biol Chem 286(9): 7522-7534.
  9. Kloo, B., Nagel, D., Pfeifer, M., Grau, M., Duwel, M., Vincendeau, M., Dorken, B., Lenz, P., Lenz, G. and Krappmann, D. (2011). Critical role of PI3K signaling for NF-kappaB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells. Proc Natl Acad Sci U S A 108(1): 272-277.
  10. Eitelhuber, A. C., Warth, S., Schimmack, G., Duwel, M., Hadian, K., Demski, K., Beisker, W., Shinohara, H., Kurosaki, T., Heissmeyer, V. and Krappmann, D. (2011). Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation. EMBO J 30(3): 594-605.
  11. Rybak, A., Fuchs, H., Hadian, K., Smirnova, L., Wulczyn, E. A., Michel, G., Nitsch, R., Krappmann, D. and Wulczyn, F. G. (2009). The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2. Nat Cell Biol 11(12): 1411-1420.
  12. Ferch, U., Kloo, B., Gewies, A., Pfander, V., Duwel, M., Peschel, C., Krappmann, D. and Ruland, J. (2009). Inhibition of MALT1 protease activity is selectively toxic for activated B cell-like diffuse large B cell lymphoma cells. J Exp Med 206(11): 2313-2320.
  13. Duwel, M., Welteke, V., Oeckinghaus, A., Baens, M., Kloo, B., Ferch, U., Darnay, B. G., Ruland, J., Marynen, P. and Krappmann, D. (2009). A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains. J Immunol 182(12): 7718-7728.
  14. Welteke, V., Eitelhuber, A., Duwel, M., Schweitzer, K., Naumann, M. and Krappmann, D. (2009). COP9 signalosome controls the Carma1-Bcl10-Malt1 complex upon T-cell stimulation. EMBO Rep 10(6): 642-648.
  15. Alessandrini, F., Beck-Speier, I., Krappmann, D., Weichenmeier, I., Takenaka, S., Karg, E., Kloo, B., Schulz, H., Jakob, T., Mempel, M. and Behrendt, H. (2009). Role of oxidative stress in ultrafine particle-induced exacerbation of allergic lung inflammation. Am J Respir Crit Care Med 179(11): 984-991.
  16. Kummel, D., Oeckinghaus, A., Wang, C., Krappmann, D. and Heinemann, U. (2008). Distinct isocomplexes of the TRAPP trafficking factor coexist inside human cells. FEBS Lett 582(27): 3729-3733.
  17. Oeckinghaus, A., Wegener, E., Welteke, V., Ferch, U., Arslan, S. C., Ruland, J., Scheidereit, C. and Krappmann, D. (2007). Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation. EMBO J 26(22): 4634-4645.
  18. Ferch, U., zum Buschenfelde, C. M., Gewies, A., Wegener, E., Rauser, S., Peschel, C., Krappmann, D. and Ruland, J. (2007). MALT1 directs B cell receptor-induced canonical nuclear factor-kappaB signaling selectively to the c-Rel subunit. Nat Immunol 8(9): 984-991.
  19. Henn, I. H., Bouman, L., Schlehe, J. S., Schlierf, A., Schramm, J. E., Wegener, E., Nakaso, K., Culmsee, C., Berninger, B., Krappmann, D., Tatzelt, J. and Winklhofer, K. F. (2007). Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling. J Neurosci 27(8): 1868-1878.
  20. Wegener, E., Oeckinghaus, A., Papadopoulou, N., Lavitas, L., Schmidt-Supprian, M., Ferch, U., Mak, T. W., Ruland, J., Heissmeyer, V. and Krappmann, D. (2006). Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation. Mol Cell 23(1): 13-23.
  21. Unterstab, G., Ludwig, S., Anton, A., Planz, O., Dauber, B., Krappmann, D., Heins, G., Ehrhardt, C. and Wolff, T. (2005). Viral targeting of the interferon-{beta}-inducing Traf family member-associated NF-{kappa}B activator (TANK)-binding kinase-1. Proc Natl Acad Sci U S A 102(38): 13640-13645.
  22. Scharschmidt, E., Wegener, E., Heissmeyer, V., Rao, A. and Krappmann, D. (2004). Degradation of Bcl10 induced by T-cell activation negatively regulates NF-kappa B signaling. Mol Cell Biol 24(9): 3860-3873.
  23. Krappmann, D., Wegener, E., Sunami, Y., Esen, M., Thiel, A., Mordmuller, B. and Scheidereit, C. (2004). The IkappaB kinase complex and NF-kappaB act as master regulators of lipopolysaccharide-induced gene expression and control subordinate activation of AP-1. Mol Cell Biol 24(14): 6488-6500.
  24. Broemer, M., Krappmann, D. and Scheidereit, C. (2004). Requirement of Hsp90 activity for IkappaB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-kappaB activation. Oncogene 23(31): 5378-5386.
  25. Mordmuller, B., Krappmann, D., Esen, M., Wegener, E. and Scheidereit, C. (2003). Lymphotoxin and lipopolysaccharide induce NF-kappaB-p52 generation by a co-translational mechanism. EMBO Rep 4(1): 82-87.
  26. Mathas, S., Hinz, M., Anagnostopoulos, I., Krappmann, D., Lietz, A., Jundt, F., Bommert, K., Mechta-Grigoriou, F., Stein, H., Dorken, B. and Scheidereit, C. (2002). Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B. EMBO J 21(15): 4104-4113.
  27. Hinz, M., Lemke, P., Anagnostopoulos, I., Hacker, C., Krappmann, D., Mathas, S., Dorken, B., Zenke, M., Stein, H. and Scheidereit, C. (2002). Nuclear factor kappaB-dependent gene expression profiling of Hodgkin's disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity. J Exp Med 196(5): 605-617.
  28. Hawkes, N. A., Otero, G., Winkler, G. S., Marshall, N., Dahmus, M. E., Krappmann, D., Scheidereit, C., Thomas, C. L., Schiavo, G., Erdjument-Bromage, H., Tempst, P. and Svejstrup, J. Q. (2002). Purification and characterization of the human elongator complex. J Biol Chem 277(4): 3047-3052.
  29. Wuchter, C., Krappmann, D., Cai, Z., Ruppert, V., Scheidereit, C., Dorken, B., Ludwig, W. D. and Karawajew, L. (2001). In vitro susceptibility to TRAIL-induced apoptosis of acute leukemia cells in the context of TRAIL receptor gene expression and constitutive NF-kappa B activity. Leukemia 15(6): 921-928.
  30. Slaugenhaupt, S. A., Blumenfeld, A., Gill, S. P., Leyne, M., Mull, J., Cuajungco, M. P., Liebert, C. B., Chadwick, B., Idelson, M., Reznik, L., Robbins, C., Makalowska, I., Brownstein, M., Krappmann, D., Scheidereit, C., Maayan, C., Axelrod, F. B. and Gusella, J. F. (2001). Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia. Am J Hum Genet 68(3): 598-605.
  31. Krappmann, D., Patke, A., Heissmeyer, V. and Scheidereit, C. (2001). B-cell receptor- and phorbol ester-induced NF-kappaB and c-Jun N-terminal kinase activation in B cells requires novel protein kinase C's. Mol Cell Biol 21(19): 6640-6650.
  32. Hinz, M., Loser, P., Mathas, S., Krappmann, D., Dorken, B. and Scheidereit, C. (2001). Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells. Blood 97(9): 2798-2807.
  33. Heissmeyer, V., Krappmann, D., Hatada, E. N. and Scheidereit, C. (2001). Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha. Mol Cell Biol 21(4): 1024-1035.
  34. Krappmann, D., Hatada, E. N., Tegethoff, S., Li, J., Klippel, A., Giese, K., Baeuerle, P. A. and Scheidereit, C. (2000). The I kappa B kinase (IKK) complex is tripartite and contains IKK gamma but not IKAP as a regular component. J Biol Chem 275(38): 29779-29787.
  35. Kordes, U., Krappmann, D., Heissmeyer, V., Ludwig, W. D. and Scheidereit, C. (2000). Transcription factor NF-kappaB is constitutively activated in acute lymphoblastic leukemia cells. Leukemia 14(3): 399-402.
  36. Emmerich, F., Meiser, M., Hummel, M., Demel, G., Foss, H. D., Jundt, F., Mathas, S., Krappmann, D., Scheidereit, C., Stein, H. and Dorken, B. (1999). Overexpression of I kappa B alpha without inhibition of NF-kappaB activity and mutations in the I kappa B alpha gene in Reed-Sternberg cells. Blood 94(9): 3129-3134.
  37. Hinz, M., Krappmann, D., Eichten, A., Heder, A., Scheidereit, C. and Strauss, M. (1999). NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition. Mol Cell Biol 19(4): 2690-2698.
  38. Heissmeyer, V., Krappmann, D., Wulczyn, F. G. and Scheidereit, C. (1999). NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes. EMBO J 18(17): 4766-4778.
  39. Krappmann, D., Emmerich, F., Kordes, U., Scharschmidt, E., Dorken, B. and Scheidereit, C. (1999). Molecular mechanisms of constitutive NF-kappaB/Rel activation in Hodgkin/Reed-Sternberg cells. Oncogene 18(4): 943-953.
  40. Wulczyn, F. G., Krappmann, D. and Scheidereit, C. (1998). Signal-dependent degradation of IkappaBalpha is mediated by an inducible destruction box that can be transferred to NF-kappaB, bcl-3 or p53. Nucleic Acids Res 26(7): 1724-1730.
  41. Krappmann, D. and Scheidereit, C. (1997). Regulation of NF-kappa B activity by I kappa B alpha and I kappa B beta stability. Immunobiology 198(1-3): 3-13.
  42. Bargou, R. C., Emmerich, F., Krappmann, D., Bommert, K., Mapara, M. Y., Arnold, W., Royer, H. D., Grinstein, E., Greiner, A., Scheidereit, C. and Dorken, B. (1997). Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells. J Clin Invest 100(12): 2961-2969.
  43. Krappmann, D., Wulczyn, F. G. and Scheidereit, C. (1996). Different mechanisms control signal-induced degradation and basal turnover of the NF-kappaB inhibitor IkappaB alpha in vivo. EMBO J 15(23): 6716-6726.
  44. Bargou, R. C., Leng, C., Krappmann, D., Emmerich, F., Mapara, M. Y., Bommert, K., Royer, H. D., Scheidereit, C. and Dorken, B. (1996). High-level nuclear NF-kappa B and Oct-2 is a common feature of cultured Hodgkin/Reed-Sternberg cells. Blood 87(10): 4340-4347.

Review articles

  1. Krappmann, D. (2012). Attacking MALT1 for ABC-DLBCL therapy. Oncotarget 3(12): 1489-1490.
  2. Hadian, K. and Krappmann, D. (2011). Signals from the nucleus: activation of NF-kappaB by cytosolic ATM in the DNA damage response. Sci Signal 4(156): pe2.
  3. Wegener, E. and Krappmann, D. (2007). CARD-Bcl10-Malt1 signalosomes: missing link to NF-kappaB. Sci STKE 2007(384): pe21.
  4. Schmitz, M. L. and Krappmann, D. (2006). Controlling NF-kappaB activation in T cells by costimulatory receptors. Cell Death Differ 13(5): 834-842.
  5. Krappmann, D. and Scheidereit, C. (2005). A pervasive role of ubiquitin conjugation in activation and termination of IkappaB kinase pathways. EMBO Rep 6(4): 321-326.
  6. Hatada, E. N., Krappmann, D. and Scheidereit, C. (2000). NF-kappaB and the innate immune response. Curr Opin Immunol 12(1): 52-58.
  7. Wulczyn, F. G., Krappmann, D. and Scheidereit, C. (1996). The NF-kappa B/Rel and I kappa B gene families: mediators of immune response and inflammation. J Mol Med (Berl) 74(12): 749-769.

Book chapters

  1. Duwel, M., Hadian, K. and Krappmann, D. (2010). Ubiquitin Conjugation and Deconjugation in NF-kappaB Signaling. Subcell Biochem 54: 88-99.
  2. Wegener, E. and Krappmann, D. (2008). Dynamic protein complexes regulate NF-kappaB signaling. Handb Exp Pharmacol(186): 237-259.
  3. Scheidereit, C. and Krappmann, D. (2006) NF-κB pathway. In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. Ganten, D. & Ruckpaul, K. (Eds.). Springer Berlin Heidelberg.
  4. Scheidereit, C., Krappmann, D. and Wulczyn, F.G. (1996) Regulation of the NF-κB family of transcription factors by protein phosphorylation. In: Protein phosphorylation and cell growth regulation. M Clemens Ed Harwood Academic Publishers.
相关资源
广告服务
作者指南
关于
©  Bio-protocol LLC. ISSN: 2331-8325
京ICP备11029730号-1
服务条款 隐私权 联系我们