教育背景
PhD, University of Florida, 2018
实验室信息
Bacterial virulence factors, biofilm formation, colonization, infection
http://kimberlyklinelab.com/
研究方向
Bacteriology, Biometals, Stress Tolerance, Pathogenesis, Physiology, Virulence, Pathophysiology, Two Component Systems, Antimicrobial resistance
发表论文
Colomer-Winter C#, Yong AMH#, Chong KKL, Veleba M, Choo PY, Gao IH, Matysik A, Ho FK, Chen SL, Kline KA. 2024. The HtrA chaperone monitors sortase-assembled pilus biogenesis in Enterococcus faecalis. PLoS Genet. 20(8):e1011071.
Nair ZJ, Gao IH, Firras A, Chong KKL, Hill ED, Choo PY, Colomer-Winter C, Chen Q, Manzano C, Pethe K, Kline KA. 2024. An essential protease, FtsH, influences daptomycin resistance acquisition in Enterococcus faecalis. Mol Microbiol. 121(5):1021-38.
Brunson DN, Colomer-Winter C, Lam LN, Lemos JA. 2023. Identification of multiple iron uptake mechanisms in Enterococcus faecalis and their relationship to virulence. Infect Immun. 91(4):e0049622.
Kundra S, Colomer-Winter C, Lemos JA. 2020. Survival of the fittest: the relationship of (p)ppGpp with bacterial virulence. Front Microbiol. 11:601417. (Review)
Colomer-Winter C#, Flores-Mireles AL#, Kundra S, Hultgren SJ, Lemos JA. 2019. (p)ppGpp and CodY promote Enterococcus faecalis virulence in a murine model of catheter-associated urinary tract infection. mSphere. 4(4):e00392-19.
Colomer-Winter C, Lemos JA, Flores-Mireles AL. 2019. Biofilm assays on fibrinogen-coated silicone catheters and 96-well polystyrene plates. Bio Protoc. 9(6):e3196.
Colomer-Winter C, Flores-Mireles AL, Baker SP, Frank KL, Lynch AJL, Hultgren SJ, Kitten T, Lemos JA. 2018. Manganese acquisition is essential for virulence of Enterococcus faecalis. PLoS Pathog. 14(9):e1007102.
Colomer-Winter C, Gaca AO, Chuang-Smith ON, Lemos JA, Frank KL. 2018. Basal levels of (p)ppGpp differentially affect the pathogenesis of infective endocarditis in Enterococcus faecalis. Microbiology 164(10):1254-65.
Colomer-Winter C, Gaca AO, Lemos JA. 2017. Association of metal homeostasis and (p)ppGpp regulation in the pathophysiology of Enterococcus faecalis. Infect Immun. 85(7):e00260-17.
Gaca AO, Kudrin P, Colomer-Winter C, Beljantseva J, Liu K, Anderson B, Wang JD, Rejman D, Potrykus K, Cashel M, Hauryliuk V, Lemos JA. 2015. From (p)ppGpp to (pp)pGpp: Characterization of regulatory effects of pGpp synthetized by the small alarmone synthetase of Enterococcus faecalis. J Bacteriol. 197(18):2908-19.
Gaca AO, Colomer-Winter C, Lemos JA. 2015. Many means to a common end: the intricacies of (p)ppGpp metabolism and its control of bacterial homeostasis. J Bacteriol 197(7):1146-56. (Review)
Frank KL, Colomer-Winter C, Grindle SM, Lemos JA, Schlievert PM, Dunny GM. 2014. Transcriptome analysis of Enterococcus faecalis during mammalian infection shows cells undergo adaptation and exist in a stringent response state. PLoS One 9(12):e115839.