HS
评审
Heng Sun
  • Faculty, University of Macau
研究方向
  • Cancer Biology, Cell Biology, Molecular Biology
个人信息

实验室信息

Chuxia Deng Lab
https://fhs.um.edu.mo/en/staff/chuxia-deng/

研究方向

breast cancer, BRCA1, tumour heterogeneity

发表论文

Sun, H., Zeng, J., Miao, Z., Lei, J. K. C., Huang, C., Hu, L., Su, S. M., Chan, U. I., Miao, K., Zhang, X., Zhang, A., Guo, S., Meng, Y., Wong, K. H., Zhang, X. D., Xu, X., and Deng, C.-X. Dissecting the heterogeneity and tumorigenesis of BRCA1 deficient mammary tumors via single cell RNA sequencing. Theranostics, 2021,10.7150/thno.63995.
Sun, H., Zhang, X., Chan, U., Su, S., Guo, S., Xu, X. L., and Deng, C. X. In vivo Mouse Mammary Gland Formation. Bio-Protocol, 2020, 10 (13), e3667
Sun, H., Xu, X. L., and Deng, C. Preparation of Single Epithelial Cells Suspension from Mouse Mammary Glands. Bio-Protocol, 2020, 10 (4), e3530
Liu, J. L., Adhav, R., Miao, K., Su, S. M., Mo, L. H., Chan, U. I., Zhang, X., Xu, J., Li, J. J., Shu, X. D., Zeng, J. M., Zhang, X., Lyu, X., Pardeshi, L., Tan, K. L., Sun, H., Wong, K. H., Deng, C., and Xu, X. L. Characterization of BRCA1-deficient premalignant tissues and cancers identifies Plekha5 as a tumor metastasis suppressor. Nature Communications, 2020, 11 (1), 4875
Miao, K., Lei, J. H. P., Valecha, M. V., Zhang, A. P., Xu, J., Wang, L. J., Lyu, X. Y., Chen, S., Miao, Z. Q., Zhang, X., Su, S. M., Shao, F. Y., Rajendran, B. K., Bao, J. L., Zeng, J. M., Sun, H., Chen, P., Tan, K. L., Chen, Q., Wong, K. H., Xu, X. L., and Deng, C. X. NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation. Nature Communications, 2020, 11 (1), 3256
Sun, H., Miao, Z. Q., Zhang, X., Chan, U. I., Su, S. M., Guo, S., Wong, C. K. H., Xu, X. L., and Deng, C. X. Single-cell RNA-Seq reveals cell heterogeneity and hierarchy within mouse mammary epithelia. The Journal of Biological Chemistry, 2018, 293 (22), 8315-8329
Shao, F. Y., Sun, H., and Deng, C. X. Potential therapeutic targets of triple-negative breast cancer based on its intrinsic subtype. Oncotarget, 2017, 8 (42), 73329-73344
Wong, A. H. H., Li, H. R., Jia, Y. W., Mak, P. I., Martins, R. P. d. S., Liu, Y., Vong, C. M., Wong, H. C., Wong, P. K., Wang, H. T., Sun, H., and Deng, C. X. Drug screening of cancer cell lines and human primary tumors using droplet microfluidics. Scientific Reports, 2017, 7 (1), 9109
Chen, S.*, Sun, H.*, Miao, K.*, and Deng, C. X. CRISPR-Cas9: from Genome Editing to Cancer Research. International Journal Of Biological Sciences, 2016 12 (12), 1427-1436 (*, equal contribution)
Sun, H., Li, X., Fan, L., Wu, G., Li, M., and Fang, J. TRAF6 is upregulated in colon cancer and promotes proliferation of colon cancer cells. The International Journal of Biochemistry & Cell Biology, 2014, 53, 195-201
Sun, H., Li, X. B., Meng, Y., Fan, L., Li, M., and Fang, J. TRAF6 upregulates expression of HIF-1alpha and promotes tumor angiogenesis. Cancer Res, 2013, 73 (15), 4950-4959
Sun, H., Li, X., and Fang, J. Hypoxia and tumors. Chinese Bulletin of Life Sciences, 2013, 25 (2), 206-217
Chen, Y., Zhang, H. S., Fong, G. H., Xi, Q. L., Wu, G. H., Bai, C. G., Ling, Z. Q., Fan, L., Xu, Y. M., Qin, Y. Q., Yuan, T. L., Sun, H., and Fang, J. PHD3 Stabilizes the Tight Junction Protein Occludin and Protects Intestinal Epithelial Barrier Function. Journal Of Biological Chemistry, 2015, 290 (33), 20580-20589
Liu, Q., Hu, T., He, L., Huang, X., Tian, X., Zhang, H., He, L., Pu, W., Zhang, L., Sun, H., Fang, J., Yu, Y., Duan, S., Hu, C., Hui, L., Zhang, H., Quertermous, T., Xu, Q., Red-Horse, K., Wythe, J. D., and Zhou, B. Genetic targeting of sprouting angiogenesis using Apln-CreER. Nature Communications, 2015, 6, 6020
Zhou, C. F., Li, X. B., Sun, H., Zhang, B., Han, Y. S., Jiang, Y., Zhuang, Q. L., Fang, J., and Wu, G. H. Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells. IUBMB Life, 2012, 64 (9), 775-782
Xue, J., Lv, D. D., Jiao, S., Zhao, W., Li, X., Sun, H., Yan, B., Fan, L., Hu, R. G., and Fang, J. pVHL mediates K63-linked ubiquitination of nCLU. PLoS One, 2012, 7 (4), e35848
Li, X. B., Jiao, S., Sun, H., Xue, J., Zhao, W. T., Fan, L., Wu, G. H., and Fang, J. The orphan nuclear receptor EAR2 is overexpressed in colorectal cancer and it regulates survivability of colon cancer cells. Cancer Letters, 2011, 309 (2), 137-144
Meng, D., Lv, D. D., Zhuang, X., Sun, H., Fan, L., Shi, X. L., and Fang, J. Benzo[a]pyrene induces expression of matrix metalloproteinases and cell migration and invasion of vascular smooth muscle cells. Toxicology Letters, 2009, 184 (1), 44-49