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David M Favara
  • Clinical Lecturer in Medical Oncology, MRC Laboratory of Molecular Biology, Cambridge
研究方向
  • Biochemistry, Cancer Biology, Cell Biology, Molecular Biology
个人信息

教育背景

DPhil (PhD), University of Oxford, 2017

实验室信息

Chris Tate laboratory, Division of Structural Studies, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
https://www2.mrc-lmb.cam.ac.uk/group-leaders/t-to-z/chris-tate/

研究方向

Adhesion GPCRs; GPCR structural biology; GPCRs in oncology; medical oncology

发表论文

Publication list of December 9, 2025:

Publications in scientific journals

1) Favara DM. Weathering the storm: The impact of weather events, lockdowns and holidays on oncology and general emergency presentations to a United Kingdom tertiary centre - a 7.5-year review. Clin Oncol (R Coll Radiol). In press 29 Nov 2025 doi: 10.1016/j.clon.2025.103991
2) Chen Q, Gusach A, Diamante A, Patel JC, Edwards PC, Tate CG, Favara DM. Structure of the Gq-coupled adhesion receptor ADGRL4, a GPCR implicated in cancer. bioRxiv doi: https://doi.org/10.1101/2025.10.03.680274 (Accepted by Nature Communications 12/2025)
3) Cheng MTK, White N, Frost S, Attia H, Favara DM. Weathering the storm: The impact of weather events, lockdowns and holidays on oncology and general emergency presentations to a United Kingdom tertiary centre - a 7.5-year review. Clin Oncol (R Coll Radiol). 2025 Aug:44:103879. doi: 10.1016/j.clon.2025.103879.
4) Cheng MTK, Morris JS, Shah SFH, Tolley A, Chen-Xu J, Sogandji N, Fong LH, Irodi A, Chan JTN, Kamelian K, Sievers BL, Sarela S, Ho MK, Burn A, Patel A, Mbolo GD, Hasan M, Fehintola AO, Yin CC, Spata E, Gupta RK, Favara DM. Determinants of SARS-CoV-2 outcomes in patients with cancer vs controls without cancer: a multivariable meta-analysis with genomic imputation. EClinicalMedicine. 2025 May 2:83:103194. doi: 10.1016/j.eclinm.2025.103194.
5) Favara DM, Verissimo T, McCaughan F. cfDNA testing in lung cancer patients improves NHS real-world result turnaround time and treatment initiation for tumours with targetable alterations by 4 weeks. Clin Oncol (R Coll Radiol). 2024 Feb;36(2):129-131. doi: 10.1016/j.clon.2023.11.035.
6) Yam-Puc JC, Hosseini Z, Horner E, Gerber P, Beristain-Covarrubias N, Hughes R, Lulla A, Rust M, Boston R, Ali M, Fischer K, Simmons-Rosello E, O’Reilly M, Robson H, Booth L, Kahanawita L, Correa-Noguera A, Favara D, Ceron-Gutierrez L, Keller B, Craxton A, Anderson G, Sun XM, Elmer A, Saunders C, Bermperi A, Jose S, Kingston N, Mulroney T, Pinon L, Chapman M, Grigoriadou S, MacFarlane M, Willis A, Patil K, Spencer S, Staples E, Warnatz K, Buckland M, Hollfelder F, Hyvönen M, Doffinger R, Parkinson C, Lear S, Matheson N, Thaventhiran JED. Age-Associated B cells predict impaired humoral immunity after COVID-19 vaccination in patients receiving immune checkpoint blockade. Nat Commun. 2023 Jun 27;14(1):3292. doi: 10.1038/s41467-023-38810-0.
7) Sheldon H, Bridges E, Silva I, Masiero M, Favara DM, Wang D, Leek R, Snell C, Roxanis I, Kreuzer M, Gileadi U, Buffa FM, Banham A, Harris AL. ADGRL4/ELTD1 expression in breast cancer cells induces vascular normalisation and immune suppression. Mol Cancer Res. 2021 Aug 4. doi: 10.1158/1541-7786.MCR-21-0171.
8) Favara DM, K McAdam, A Cooke, R Doffinger, A Bordessa-Kelly, S Houghton, I Budriunaite, S Bossingham, N Ainsworth, P Corrie. SARS-CoV-2 antigen and antibody prevalence among UK staff working with cancer patients during the COVID-19 pandemic. Clin Oncol (R Coll Radiol). 2021 Oct;33(10):667–675.
9) Albecka A, Clift D, Vaysburd M, Rhinesmith T, Caddy SL, Favara DM, Baxendale HE, James LC. A functional assay for serum detection of antibodies against SARS-CoV-2 nucleoprotein. EMBO J. 2021 Jul 29;e108588. doi: 10.15252/embj.2021108588.
10) Favara DM, Liebscher I, Jazayeri I, Nambiar N, Sheldon H, Banham AH, Harris AL. Elevated expression of the adhesion GPCR ADGRL4/ELTD1 promotes endothelial sprouting angiogenesis without activating canonical GPCR signalling. Sci Rep 11, 8870 (2021). https://doi.org/10.1038/s41598-021-85408-x.
11) Favara DM, ML Ceron-Gutierrez, GW Carnell, JL Heeney, P Corrie, R Doffinger. Detection of breastmilk antibodies targeting SARS-CoV-2 nucleocapsid, spike and receptor-binding-domain antigens. Emerg Microbes Infect. 2020 Dec;9(1):2728-2731.
12) Favara DM, Spain L, Au L, Clark J, Daniels E, Diem S, Chauhan D, Turajlic S, Gore M, Powell N, Larkin J, Yousaf N. A five-year review of corticosteroid duration and complications in the management of immune checkpoint inhibitor related diarrhoea and colitis in advanced melanoma at the Royal Marsden Hospital. ESMO Open. 2020 Jul;5(4):e000585. doi: 10.1136/esmoopen-2019-000585.
13) Favara DM, Cooke A, Doffinger R, McAdam K, Corrie P, Ainsworth NL. COVID-19 Serology in Oncology Staff (CSOS) Study: understanding SARS-CoV-2 in the oncology workforce. Clin Oncol (R Coll Radiol). 2020 Jul 25;S0936-6555(20)30297-1.
14) Burman RJ, de Wet TJ, Amoni M, Düsterwald KM, Favara DM, Setshedi M, Rametse CL, Katz AA. Training South African clinician-scientists: Lessons from the University of Cape Town’s intercalated programme. S Afr Med J. 2019 Nov;109(12):914-918.
15) Favara DM, Zois C, Haider S, Pires E, Sheldon H, McCullagh J, Banham AH, Harris AL. ADGRL4/ELTD1 silencing in endothelial induces ACLY and SLC25A1 and alters the cellular metabolic profile. Metabolites. 2019 Nov 25;9(12). pii: E287. doi: 10.3390/metabo9120287.
16) Favara DM, Banham AH, Harris AL. ADGRL4/ELTD1 is a highly conserved angiogenesis-associated orphan adhesion GPCR that emerged with the first vertebrates and comprises 3 evolutionary variants. BMC Evol Biol. 2019 Jul 12;19(1):143. doi: 10.1186/s12862-019-1445-9.
17) Favara DM. Theodor Billroth: A Surgeon for the 21st Century. Am Surg. 2014 Dec;80(12):1192-5.
18) Favara DM, Banham AH, Harris AL. A review of ELTD1, a pro-angiogenic adhesion GPCR. Biochem Soc Trans. 2014 Dec 1;42(6):1658-64.
19) Favara DM. Harris AL. VEGF sticky‐trap: the first report of a non‐systemically acting angiogenesis inhibitor. EMBO Mol Med. 2014 May 6;6(5):577–9.
20) Favara DM. Creating and developing a non-profit community-outreach healthcare clinic in the developing world: lessons learnt in South Africa. Int J Clin Pract. 2014 May;68(5):536-40.
21) Favara DM, Makin L. Chesed Children’s Clinic: A non-profit, paediatric primary care outreach clinic in the Eastern Cape created by junior doctors and volunteers. S Afr Med J. 2013 Apr;103(6):356-357.
22) Favara DM. The burden of deliberate self-harm on the critical care unit of a peri-urban referral hospital in the Eastern Cape: A 5-year review of 419 patients. S Afr Med J 2013;103(1):40-43.
23) Favara DM, DC Cohen, U Ilyas, J Kinross, D Taylor, P Paraskevas, N Batrick, N Sevdalis, A Darzi. Virtual Worlds in Trauma Team Training: An international South Africa and United Kingdom feasibility study. 40th Annual Meeting of the Surgical Research Society of Southern Africa: 11 - 12 July 2012. SAJS 2012;50(Supplement), pp 61-62 [Abstract only].
24) Favara DM. The burden of deliberate self-harm admissions on the critical care unit of a typical South African peri-urban referral hospital: A 5-year review. S Afr J Crit Care 2012;28(1):35-36. DOI:10.7196/SAJCC.141 [Abstract only].
25) Favara DM, Mendelsohn SC. The Student’s Health and Welfare Centres Organisation (SHAWCO) of the University of Cape Town: A review of the past 69 years. S Afr Med J 2012;102(6):400-402.
26) Favara DM, Levy M. Acute urinary retention as a complication of primary varicella-zoster infection of childhood – a second reported case. S Afr Med J. 2012 Mar 14;102(4):196.
27) Favara DM, Kahn D. An Elixir for the Troubled Future of General Surgery in South Africa. World J Surg. 2012 Feb;36(2):475-6.
28) Favara DM, Kahn D. The Student Surgical Society: The South African experience. World J Surg (2011) 35:S1 pg69 [Abstract only].
29) Favara DM, Kahn D. A Student Surgical Society: The Cape Town Experience. SAJS Vol 49, No3 (2011), pp 132-134.
30) Favara DM, Crede T, Blockman M, Berman P. Methaemoglobinaemia: Mystery of the chocolate-brown blood. CMEJ (SA). Volume 28, Issue 2, pp 79-82, 2010.