生物物理学

分类

    现刊
    OrganoPlate Micro-fluidic Microvessel Culture and Analysis
    OrganoPlate微流控微血管培养与分析
    作者:Abidemi Junaid and Thomas Hankemeier日期:07/05/2021,浏览量:1451,Q&A: 0
    [Abstract]

    The endothelial cells from the microvasculature are key drivers and targets of inflammatory and thrombotic processes in microvascular diseases. The study of bioactive lipids in inflammatory processes has been largely based on two-dimensional endothelial cell cultures. Three-dimensional microvessels-on-a-chip provides an opportunity to monitor the

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    Surface Engineering and Multimodal Imaging of Multistage Delivery Vectors in Metastatic Breast Cancer
    转移性乳腺癌多期转运载体的表面工程和多模态成像
    作者:Shreya Goel, Mauro Ferrari and Haifa Shen日期:05/20/2021,浏览量:3575,Q&A: 0
    [Abstract]

    The design of effective nanoformulations that target metastatic breast cancers is challenging due to a lack of competent imaging and image analysis protocols that can capture the interactions between the injected nanoparticles and metastatic lesions. Here, we describe the integration of in vivo whole-body PET-CT with high temporal resolution, ex

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    Developing Biohybrid Robotic Jellyfish (Aurelia aurita) for Free-swimming Tests in the Laboratory and in the Field
    开发的生物合成机器人水母在室内和室外的自由游泳测试
    作者:Nicole W. Xu, James P. Townsend, John H. Costello, Sean P. Colin, Brad J. Gemmell and John O. Dabiri日期:04/05/2021,浏览量:2011,Q&A: 0
    [Abstract]

    Biohybrid robotics is a growing field that incorporates both live tissues and engineered materials to build robots that address current limitations in robots, including high power consumption and low damage tolerance. One approach is to use microelectronics to enhance whole organisms, which has previously been achieved to control the locomotion of

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    Live Cell FRET Analysis of the Conformational Changes of Human P-glycoprotein
    人P-糖蛋白构象变化的活细胞FRET分析
    作者:Ryota Futamata, Noriyuki Kioka and Kazumitsu Ueda日期:02/20/2021,浏览量:2595,Q&A: 0
    [Abstract]

    The molecular mechanisms of P-glycoprotein (P-gp; also known as MDR1 or ABCB1) have been mainly investigated using artificial membranes such as lipid-detergent mixed micelles, artificial lipid bilayers, and membrane vesicles derived from cultured cells. Although these in vitro experiments help illustrate details about the molecular mechanisms of

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    Efficient Transient Gene Knock-down in Tobacco Plants Using Carbon Nanocarriers
    应用碳纳米载体对烟草基因进行高效瞬时敲减
    作者:Gozde S. Demirer and Markita P. Landry日期:01/05/2021,浏览量:2466,Q&A: 0
    [Abstract] Gene knock-down in plants is a useful approach to study genotype-phenotype relationships, render disease resistance to crops, and enable efficient biosynthesis of molecules in plants. Small interfering RNA (siRNA)-mediated gene silencing is one of the most common ways to achieve gene knock-down in plants. Traditionally, siRNA is delivered into ...
    Mechanical Characterization of Glandular Acini Using a Micro-indentation Instrument
    使用微压痕仪对腺泡进行机械表征
    作者:Christopher S. O’Bryan, Qiao Zhang, Tanmay P. Lele and Thomas E. Angelini日期:12/05/2020,浏览量:2095,Q&A: 0
    [Abstract]

    The linker of nucleoskeleton and cytoskeleton (LINC) complex is responsible for tethering the nucleus to the cytoskeleton, providing a pathway for the cell’s nucleus to sense mechanical signals from the environment. Recently, we explored the role of the LINC complex in the development of glandular epithelial acini, such as those found in

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    Production and Isolation of Magnetic Protein Crystals in HEK293T Cells
    HEK293T细胞中磁性蛋白晶体的生产与分离
    作者:Thomas L. Li and Bianxiao Cui日期:07/20/2020,浏览量:1906,Q&A: 0
    [Abstract] Advances in protein engineering have enabled the production of self-assembled protein crystals within living cells. Our recent publication demonstrates the production of ftn-PAK4, which is a ferritin-containing crystal that can mineralize iron and become magnetic when isolated. We have developed an optimized protocol for the production and ...
    Preparation and Characterization of Ginger Lipid-derived Nanoparticles for Colon-targeted siRNA Delivery
    用于向结肠靶向siRNA递送的生姜脂质纳米粒的制备与表征
    作者:Junsik Sung, Chunhua Yang, James F. Collins and Didier Merlin日期:07/20/2020,浏览量:1424,Q&A: 0
    [Abstract] Synthetic nanoparticle-based drug delivery system is widely known for its ability to increase the efficacy and specificity of loaded drugs, but it often suffers from relatively higher immunotoxicity and higher costs as compared to traditional drug formulations. Contrarily, plant-derived nanoparticles appear to be free from these limitations of ...
    Evaluating Whole Blood Clotting in vitro on Biomaterial Surfaces
    生物材料表面进行全血凝固的体外评估
    作者:Roberta M Sabino and Ketul C Popat日期:02/05/2020,浏览量:3162,Q&A: 0
    [Abstract] Biomaterial-associated thrombosis is still a major concern for blood-contacting implants. After the medical device is implanted and comes in contact with blood, several complex reactions occur, which may lead to thrombus formation and failure of the device. Therefore, it is essential to evaluate the biomaterial interaction with the whole blood. ...
    Opto-magnetic Selection and Isolation of Single Cells
    单细胞的光磁筛选及分离
    作者:Loïc Binan, Joannie Roy and Santiago Costantino日期:11/20/2019,浏览量:2259,Q&A: 0
    [Abstract] Capturing single cells from large heterogenous populations based solely on observable traits is necessary for many cell biology applications and remains a major technical challenge. The protocol we present allows the isolation of viable and metabolically active cells selected for their shape, migration speed, contact to other cells, or ...