神经科学

分类

    现刊
    Cylinder Test to Assess Sensory-motor Function in a Mouse Model of Parkinson’s Disease
    基于圆筒试验的小鼠帕金森综合症模型中感觉运动系统功能测试
    [Abstract] Parkinson’s disease is a progressive neurodegenerative movement disorder that happens due to the loss of dopaminergic neurons in the substantia nigra. The deficiency of dopamine in the basal nuclei drives cardinal motor symptoms such as bradykinesia and hypokinesia. The current protocol describes the cylinder test, which is a relatively simple ...
    α-Synuclein Aggregation Monitored by Thioflavin T Fluorescence Assay
    通过硫磺素T荧光测定法监测核突触蛋白聚集
    作者:Michael M. Wördehoff and Wolfgang Hoyer日期:07/20/2018,浏览量:8302,Q&A: 1
    [Abstract] Studying the aggregation of amyloid proteins like α-synuclein in vitro is a convenient and popular tool to gain kinetic insights into aggregation as well as to study factors (e.g., aggregation inhibitors) that influence it. These aggregation assays typically make use of the fluorescence dye Thioflavin T as a sensitive ...