生物化学

分类

    现刊
    A Highly Sensitive Anion Exchange Chromatography Method for Measuring cGAS Activity in vitro
    一种体外检测cGAS活性的高效阴离子交换色谱法
    作者:Andreas Holleufer and Rune Hartmann日期:10/20/2018,浏览量:3845,Q&A: 0
    [Abstract] Cyclic GMP-AMP synthase (cGAS) is a pattern recognition receptor (PRR) that senses double stranded DNA (dsDNA) in the cytosol and this leads to the activation of stimulator of interferon genes (STING) via the secondary messenger 2’3’-cyclic GMP-AMP (2’3’-cGAMP). STING then recruits TANK binding kinase 1 (TBK-1) and this complex can phosphorylate ...