神经科学

分类

    现刊
    A Time Duration Discrimination Task for the Study of Elapsed Time Processing in Rats
    用于研究大鼠执行时间的时程辨别任务
    [Abstract]

    Space and time are both essential features of episodic memory. However, while spatial tasks have been used effectively to study the behavioral relevance of place cells, the behavioral paradigms utilized for the study of time cells have not used time duration as a variable that animals need to be aware of to solve the task. In order to evaluate how

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    Dissociating Behavior and Spatial Working Memory Demands Using an H Maze
    利用H迷宫研究分离行为和空间工作记忆需求
    作者:Hannah S. Wirtshafter, Moqing Quan and Matthew A. Wilson日期:03/05/2021,浏览量:1445,Q&A: 0
    [Abstract]

    The development of mazes for animal experiments has allowed for the investigation of cognitive maps and place cells, spatial working memory, naturalistic navigation, perseverance, exploration, and choice and motivated behavior. However, many mazes, such as the T maze, currently developed to test learning and memory, do not distinguish temporally

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    The Peak Interval Procedure in Rodents: A Tool for Studying the Neurobiological Basis of Interval Timing and Its Alterations in Models of Human Disease
    啮齿类动物的峰值间隔程序:研究人类疾病模型中间隔时间及其变化的神经生物学基础的工具
    作者:Fuat Balcı and David Freestone日期:09/05/2020,浏览量:1851,Q&A: 0
    [Abstract] Animals keep track of time intervals in the seconds to minutes range with, on average, high accuracy but substantial trial-to-trial variability. The ability to detect the statistical signatures of such timing behavior is an indispensable feature of a good and theoretically-tractable testing procedure. A widely used interval timing procedure is the ...
    Sequential Reaching Task for the Study of Motor Skills in Monkeys
    猴子运动技能研究的连续性达标任务
    作者:Machiko Ohbayashi and Nathalie Picard日期:08/20/2020,浏览量:1652,Q&A: 0
    [Abstract] The ability to perform a sequence of movements is a key component of motor skills, such as typing or playing a musical instrument. How the brain binds elementary movements together into meaningful actions has been a topic of much interest. Here, we describe two sequential reaching tasks that we use to investigate the neural substrate of skilled ...
    Multiple Simultaneous Acute Stresses in Mice: Single or Repeated Induction
    小鼠多重同时急性应激:单次或重复诱导
    [Abstract] Stress is crucial to the survival of an organism, but excessive stress can lead to psychological disorders including depression, anxiety, substance abuse, and suicidality. The prevailing notion is that chronic stress promotes adverse outcomes on brain and body health, whereas acute stressors are generally benign. Notably, acute events such mass ...
    The Discrete Paired-trial Variable-delay T-maze Task to Assess Working Memory in Mice
    利用T迷宫评价小鼠工作记忆的非连续配对变换延迟任务
    作者:Gian Marco Leggio, Sebastiano Alfio Torrisi and Francesco Papaleo日期:07/05/2020,浏览量:2116,Q&A: 0
    [Abstract] Working memory abnormalities involving the prefrontal cortex (PFC) dramatically contribute to poor functional outcomes in patients with schizophrenia and still represent an unmet therapeutic need. Studies in rodents might provide essential tools to understand the mechanisms underlying PFC-dependent working memory dysfunctions, as well as precious ...
    An Alternative Maze to Assess Novel Object Recognition in Mice
    一种评价小鼠新目标识别的替代迷宫
    [Abstract] The novel object recognition (NOR) task is a behavioral test commonly used to evaluate episodic-like declarative memory and it relies on the innate tendency of rodents to explore novelty. Here we present a maze used to evaluate NOR memory in mice that reduces the time of the assay while improving reliability of the measurements by increasing the ...
    Enriched Environment Procedures for Rodents: Creating a Standardized Protocol for Diverse Enrichment to Improve Consistency across Research Studies
    啮齿动物的环境丰容程序:创建提高研究一致性的多样化富集标准化协议
    作者:Bruce C. Harland and John C. Dalrymple-Alford日期:06/05/2020,浏览量:1814,Q&A: 0
    [Abstract] Exposure to environmental enrichment has beneficial effects on learning and memory, diverse neurobiological effects, and promotes recovery of function after brain injury. The effect of enrichment is produced by a combination of increased social interaction, physical activity, spatial complexity, and novelty. Procedures in the literature have, ...
    Protocol for Measuring Free (Low-stress) Exploration in Rats
    大鼠自由(低应力)探索测量方案
    作者:Wojciech Pisula and Klaudia Modlinska日期:01/20/2020,浏览量:2415,Q&A: 0
    [Abstract] Research on exploratory behavior plays a key part in behavioral science. Studying exploratory behavior of laboratory rodents may provide important data about many developmental and neurobiological processes occurring in animal ontogenesis. The proposed protocol for measuring the free (low-stress) exploration behavior in rats is straightforward, ...
    Trial-based Discrimination Procedure for Studying Drug Relapse in Rats
    基于试验的大鼠药物复发鉴别研究
    作者:Veronica A Lennon, Megan B Brenner, Sophia J Weber, Lauren E Komer and Rajtarun Madangopal日期:12/05/2019,浏览量:2545,Q&A: 0
    [Abstract] In abstinent drug addicts, cues formerly associated with drug-taking experiences gain relapse-inducing potency (‘incubate’) over time. Animal models of incubation may help in developing treatments for relapse prevention. However, these models have primarily focused on the role of conditioned stimuli (CSs) signaling drug delivery and not ...