系统生物学

分类

    现刊
    Computational Analysis and Phylogenetic Clustering of SARS-CoV-2 Genomes
    SARS-CoV-2基因组计算分析及系统进化聚类分析
    作者:Bani Jolly and Vinod Scaria日期:04/20/2021,浏览量:2878,Q&A: 0
    [Abstract]

    COVID-19, the disease caused by the novel SARS-CoV-2 coronavirus, originated as an isolated outbreak in the Hubei province of China but soon created a global pandemic and is now a major threat to healthcare systems worldwide. Following the rapid human-to-human transmission of the infection, institutes around the world have made efforts to generate

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    HoSeIn: A Workflow for Integrating Various Homology Search Results from Metagenomic and Metatranscriptomic Sequence Datasets
    HoSeIn:整合来自宏基因组和元转录组序列数据集的各种同源性搜索结果的工作流
    作者:Gaston Rozadilla, Jorgelina Moreiras Clemente and Christina B. McCarthy日期:07/20/2020,浏览量:2369,Q&A: 0
    [Abstract] Data generated by metagenomic and metatranscriptomic experiments is both enormous and inherently noisy. When using taxonomy-dependent alignment-based methods to classify and label reads, the first step consists in performing homology searches against sequence databases. To obtain the most information from the samples, nucleotide sequences are ...
    Genome-wide Estimation of Evolutionary Distance and Phylogenetic Analysis of Homologous Genes
    进化距离的全基因组评估和同源基因的系统进化分析
    作者:Meixia Zhao, Biao Zhang, Jianxin Ma and Damon Lisch日期:12/05/2018,浏览量:5082,Q&A: 0
    [Abstract] Homologous genes, including paralogs and orthologs, are genes that share sequence homologies within or between different species. Homologous genes originate from a common origin through speciation, genetic duplication or horizontal gene transfer. Estimation of the sequence divergence of homologous genes help us to understand divergence time, which ...
    Extraction of DNA from Murine Fecal Pellets for Downstream Phylogenetic Microbiota Analysis by Next-generation Sequencing
    采用新一代测序技术从小鼠粪粒中提取DNA进行下游微生物群进化分析
    作者:Elien Eeckhout and Andy Wullaert日期:02/05/2018,浏览量:9278,Q&A: 2
    [Abstract] Mouse models are widely used to evaluate the potential impact of the gut microbial composition on health and disease. Standardized protocols for sampling and storing murine feces, as well as for extracting DNA from these fecal pellets are needed to limit experimental variation between different studies. Both efficient lysis of the microbiota and ...
    Character-State Reconstruction to Infer Ancestral Protein-Protein Interaction Patterns
    特征状态重建法推断遗传蛋白质相互作用模式
    作者:Florian Rümpler, Günter Theißen and Rainer Melzer日期:08/20/2015,浏览量:11006,Q&A: 0
    [Abstract] Protein-protein interactions are at the core of a plethora of developmental, physiological and biochemical processes. Consequently, insights into the origin and evolutionary dynamics of protein-protein interactions may provide information on the constraints and dynamics of specific biomolecular circuits and their impact on the organismal ...