神经科学

分类

    现刊
    An Improved Method for Individual Tracking of Voluntary Wheel Running in Pair-housed Juvenile Mice
    一种对饲养的幼鼠自主跑轮运动个体跟踪的改进方法
    作者:David A. Valientes, Anthony M. Raus and Autumn S. lvy日期:07/05/2021,浏览量:938,Q&A: 0
    [Abstract]

    Rodent cages equipped with access to a voluntary running wheel are commonly used to study the effects of aerobic physical activity on physiology and behavior. Notable discoveries in exercise neurobiology, including the key role of brain-derived neurotrophic factor (BDNF) in neural plasticity and cognition, have been made using rodents housed with

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    Evaluating Baseline and Sensitised Heat Nociception in Adult Drosophila
    评估成年果蝇的基线和致敏热伤害感受
    作者:Josephine N. Massingham, Olga Baron and G. Gregory Neely日期:07/05/2021,浏览量:762,Q&A: 0
    [Abstract]

    Chronic pain is a complex disease that affects a large proportion of the population. With little to no effective treatments currently available for patients, this malady presents a large burden to society. Drosophila melanogaster has been previously used to describe conserved molecular components of nociception in larvae and adults. However, adult

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    Objective Quantitation of Focal Sweating Areas Using a Mouse Sweat-assay Model
    小鼠汗液分析模型对局部出汗区域的客观定量
    作者:Choongjin Ban and Dae-Hyuk Kwoen日期:06/05/2021,浏览量:1203,Q&A: 0
    [Abstract]

    In vivo sweat quantitation assays are required for the development of drugs for the management of focal hyperhidrosis before clinical trials; however, in vivo assays, particularly mouse models, are rare. Even in sweat assays using mice, sweating is quantitated by manually counting the number of sweating spots, which can contribute to various

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    Long-term Devocalization of Zebra Finches
    斑马雀的长期清音化研究
    作者:Yunbok Kim, Daisuke Mizuguchi and Satoshi Kojima日期:09/20/2020,浏览量:2017,Q&A: 0
    [Abstract] Songbirds, such as the zebra finch, are a popular animal model for studying the neural basis of vocal and complex skill learning. Adult male zebra finches produce courtship song toward females (referred to as ‘directed song’) and recording and analyzing sounds of directed song along with underlying neural activity is important for investigating ...
    Sequential Reaching Task for the Study of Motor Skills in Monkeys
    猴子运动技能研究的连续性达标任务
    作者:Machiko Ohbayashi and Nathalie Picard日期:08/20/2020,浏览量:1416,Q&A: 0
    [Abstract] The ability to perform a sequence of movements is a key component of motor skills, such as typing or playing a musical instrument. How the brain binds elementary movements together into meaningful actions has been a topic of much interest. Here, we describe two sequential reaching tasks that we use to investigate the neural substrate of skilled ...
    A Reproducible Protocol to Measure the Critical Swimming Speed of Adult Zebrafish
    一种可重复性测定成年斑马鱼临界游泳速度的方法
    作者:Yuma Wakamatsu, Makoto Kashima and Hiromi Hirata日期:08/20/2020,浏览量:2499,Q&A: 1
    [Abstract] The quantitative measurement of water flow-induced swimming of fish species using a swimmill is a powerful method to evaluate motor ability of individual fish. Zebrafish is a commonly used vertebrate that enables the study of morphological, physiological and behavioral characteristics associated with genes. We here established a reproducible ...
    Precise Targeting of Single Microelectrodes to Orientation Pinwheel Centers
    单微电极精确定位风车中心区
    作者:Xue Mei Song, Ming Li, Tao Xu, Dewen Hu and Anna Wang Roe日期:06/05/2020,浏览量:1501,Q&A: 0
    [Abstract] In the mammalian visual system, early stages of visual form perception begin with orientation selective neurons in primary visual cortex (V1). In many species (including humans, monkeys, tree shrews, cats, and ferrets), these neurons are organized in pinwheel-like orientation columns. To study the functional organization within orientation ...
    Minimally Invasive Oral Surgery Induction of the FRICT-ION Chronic Neuropathic Pain Model
    微创口腔手术诱导FRICT-ION慢性神经病理性疼痛模型的建立
    作者:Marena A. Montera and Karin N. Westlund日期:04/20/2020,浏览量:2155,Q&A: 0
    [Abstract] An easily induced preclinical trigeminal neuropathic nerve injury model is described here for the study of chronic pain, the model acronym FRICT-ION (Foramen Rotundum Inflammatory Constriction Trigeminal InfraOrbital Nerve). In patients, neuropathic pain is thought to be related to ...
    A Simple and Fast Battery Test for Phenotypic Characterization of Mice
    小鼠表型特征的简易快速系列测试试验
    [Abstract] Despite the great number of test batteries already known to assess the behavior of genetically modified and inbred strains of mice, only a few of them focus on basic neurological parameters. The purpose of the battery test proposed is to settle a specific methodology to characterize the phenotype of neurological disease models in mutant or ...
    Semi-automated Model to Accurately Counting Sympathetic Nervous Fibers
    交感神经纤维精确计数的半自动模型
    作者:Dennis Bleck, Lkham Erdene-Byambadoo, Ralph Brinks, Matthias Schneider and Georg Pongratz日期:12/20/2019,浏览量:2468,Q&A: 0
    [Abstract] In recent years, the role of sympathetic nervous fibers in chronic inflammation has become increasingly evident. At the onset of inflammation, sympathetic activity is increased in the affected tissue. However, sympathetic fibers are largely absent from chronically inflamed tissues. Apparently, there is a very dynamic relationship between ...