联合作者(
Michael Riedelberger Center for Medical Biochemistry, Max Perutz Labs Vienna, Campus Vienna Biocenter, Medical University of Vienna
1 protocol

Sabrina Jenull Medical University Vienna, Max F. Perutz Laboratories, Department of Medical Biochemistry, Austria
1 protocol

Miha Tome Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Slovenia
1 protocol

Fabian Istel Medical University Vienna, Max F. Perutz Laboratories, Department of Medical Biochemistry, Austria
4 protocols

顾问
Karl Kuchler
  • Professor of Molecular genetics, Medical University of Vienna, Center for Medical Biochemistry, Max Perutz Labs Vienna, Campus Vienna Biocenter, A-1030 Vienna
研究方向
  • 分子生物学
  • Karl Kuchler has a long-standing interest in fungal infection biology, molecular genetics, as well as host immune signaling at their intersections with the molecular mechanisms of antifungal drug resistance. His work discovered a novel TLR7-dependent fungal response pathway in dendritic cells, and the group discovered a molecular mechanism underlying the hyper-inflammatory host response upon fungal infections. Finally, the most work uncovered pivotal roles of fungal HDACs/HATs in controlling antifungal drug resistance, stress response, DNA repair as well as virulence.
  • 已发表 protocol 6

教育背景

Ph.D., Technical University of Graz, 1986

实验室信息

Group Leader Max F Perutz Laboratories, Department of Medical Biochemistry
Medical University Vienna, Austria

The Kuchler Lab studies fundamental problems in infection biology using a combination of molecular as well as genome-wide and systems biology approaches. They are particularly interested in a better understanding of the dynamic gene regulation during host-pathogen interplay, with a focus on fungal pathogens such as Candida spp.

More detail about Kuchler can be found at
https://tissuehome.meduniwien.ac.at/faculty/karl-kuchler/

发表论文

已发表 protocol 6篇
Analyzing the Quenchable Iron Pool in Murine Macrophages by Flow Cytometry
小鼠巨噬细胞可淬灭铁池的流式细胞分析

作者:Michael Riedelberger and Karl Kuchler日期:03/20/2020,浏览量:2994,Q&A: 0
Tissue-resident macrophages are pivotal for a tightly-regulated iron metabolism at a cellular and systemic level, since subtle iron alterations increase the susceptibility for microbial infections or drive multiple diseases. However, research on ...
Phenotypic Profiling of Candida glabrata in Liquid Media
液体介质中光滑念珠菌的表型分析

作者:Fabian Istel, Miha Tome, Sabrina Jenull and Karl Kuchler日期:04/05/2017,浏览量:9083,Q&A: 0
Here, we describe a method for a large-scale liquid screening approach in C. glabrata. This liquid media method offers several distinct advantages over solid media approaches. This includes growth measurement on a plate reader instead of ...