联合作者(
Ming O. Li Immunology Program, Memorial Sloan Kettering Cancer Center, USA
3 protocols
联合评审(
Benoit Chassaing Georgia State University
14 protocols

Benoit Stijlemans Vrije Universiteit Brussel
5 protocols

Chris Tibbitt Karolinska Institutet
5 protocols

Christina Yan Ru Tan Agency for Science, Technology and Research (A*STAR)
4 protocols

编委
Ruth A. Franklin
  • Yale University
研究方向
  • 免疫学
  • 已发表 protocol 1

Education

Ph.D. in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY, 2014

Current position

Postdoctoral Research Fellow, Department of Immunobiology, Yale School of Medicine, New Haven, CT

Publications

  1. Dadi, S., Chhangawala, S., Whitlock, B. M., Franklin, R. A., Luo, C. T., Oh, S. A., Toure, A., Pritykin, Y., Huse, M., Leslie, C. S. and Li, M. O. (2016). Cancer immunosurveillance by tissue-resident innate lymphoid cells and innate-like T cells. Cell 164(3): 365-377.
  2. Franklin, R. A. and Li, M. O. (2016). Ontogeny of tumor-associated macrophages and its implication in cancer regulation. Trends Cancer 2(1): 20-34.      
  3. Franklin, R. A. and Li, M. O. (2014). The ontogeny of tumor-associated macrophages: a new understanding of cancer-elicited inflammation. Oncoimmunology 3(9): e955346.
  4. Franklin, R. A., Liao, W., Sarkar, A., Kim, M. V., Bivona, M. R., Liu, K., Pamer, E. G. and Li, M. O. (2014). The cellular and molecular origin of tumor-associated macrophages. Science 344(6186): 921-925.
  5. Donkor, M. K., Sarkar, A., Savage, P. A., Franklin, R. A., Johnson, L. K., Jungbluth, A. A., Allison, J. P. and Li, M. O. (2011). T cell surveillance of oncogene-induced prostate cancer is impeded by T cell-derived TGF-beta1 cytokine. Immunity 35(1): 123-134.
  6. Dorrell, M. I., Aguilar, E., Jacobson, R., Trauger, S. A., Friedlander, J., Siuzdak, G. and Friedlander, M. (2010). Maintaining retinal astrocytes normalizes revascularization and prevents vascular pathology associated with oxygen-induced retinopathy. Glia 58(1): 43-54.
  7. Dorrell, M. I., Aguilar, E., Jacobson, R., Yanes, O., Gariano, R., Heckenlively, J., Banin, E., Ramirez, G. A., Gasmi, M., Bird, A., Siuzdak, G. and Friedlander, M. (2009). Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularization-associated oxidative stress. J Clin Invest 119(3): 611-623.
  8. Aguilar, E., Dorrell, M. I., Friedlander, D., Jacobson, R. A., Johnson, A., Marchetti, V., Moreno, S. K., Ritter, M. R. and Friedlander, M. (2008). Chapter 6. Ocular models of angiogenesis. Methods Enzymol 444: 115-158.
  9. Scheppke, L., Aguilar, E., Gariano, R. F., Jacobson, R., Hood, J., Doukas, J., Cao, J., Noronha, G., Yee, S., Weis, S., Martin, M. B., Soll, R., Cheresh, D. A. and Friedlander, M. (2008). Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits. J Clin Invest 118(6): 2337-2346.

已发表 protocol 1篇
Determining Leukocyte Origins Using Parabiosis in the PyMT Breast Tumor Model
采用联体模型在PyMT乳腺肿瘤模型中测定白血球起源

作者:Ruth A. Franklin and Ming O. Li日期:08/20/2015,浏览量:8322,Q&A: 0
Tumors develop in a complex microenvironment alongside numerous cell types that impact their survival. Immune cells make up a large proportion of these accessory cells and many are known to promote tumor progression. Macrophages, in particular, are ...
参审 protocol 5篇
RNA Sequencing of Single Myofibers from Mus musculus
小鼠单肌纤维的RNA序列分析
作者:Darren M. Blackburn, Felicia Lazure and Vahab D. Soleimani日期:02/20/2020,浏览量:3653,Q&A: 0
Whole transcriptome analysis is a key method in biology that allows researchers to determine the effect a condition has on gene regulation. One difficulty in RNA sequencing of muscle is that traditional methods are performed on the whole muscle, but ...
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In vivo Efficacy Studies in Cell Line and Patient-derived Xenograft Mouse Models
在细胞系和患者源性异种移植瘤小鼠模型中进行的体内疗效研究
作者:Elizabeth A. Tovar, Curt J. Essenburg and Carrie Graveel日期:01/05/2017,浏览量:11761,Q&A: 0
In vivo xenograft models derived from human cancer cells have been a gold standard for evaluating the genetic drivers of cancer and are valuable preclinical models for evaluating the efficacy of cancer therapeutics. Recently, ...
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主审 protocol 10篇
Isolation and Long-term Cultivation of Mouse Alveolar Macrophages
小鼠肺泡巨噬细胞的分离与长期培养
作者:Clara Jana-Lui Busch, Jérémy Favret, Laufey Geirsdóttir, Kaaweh Molawi and Michael H. Sieweke日期:07/20/2019,浏览量:6311,Q&A: 0
Alveolar macrophages (AM) are tissue-resident macrophages that colonize the lung around birth and can self-maintain long-term in an adult organism without contribution of monocytes. AM are located in the pulmonary alveoli and can be harvested by ...
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Characterization of Mouse Adult Testicular Macrophage Populations by Immunofluorescence Imaging and Flow Cytometry
免疫荧光成像和流式细胞术鉴定小鼠成人睾丸巨噬细胞群体
作者:Noushin Mossadegh-Keller and Michael H. Sieweke日期:03/05/2019,浏览量:3920,Q&A: 0
Testicular macrophages (tMΦ) are the most abundant immune cells residing in the testis, an immune-privileged organ. TMΦ are known to exhibit different functions, such as protecting spermatozoa from auto-immune attack by producing immunosuppressive ...
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