联合评审(
Giusy Tornillo Cardiff University
26 protocols

Pengpeng Li Boston Children’s Hospital
30 protocols

sujan kumar mondal University of Pittsburgh
6 protocols

Surabhi Sonam Institut Jacques Monod
6 protocols

编委
Alak Manna
  • Research associate, Mayo Clinic
研究方向
  • 癌症生物学
  • Hematology/Oncology; development of immunotherapeutics; cancer immunology

教育背景

PhD, University of Calcutta, India, 2015

实验室信息

Translational Cancer Research, Immunotherapy

发表论文

1. Manna A, Saha P, Sarkar A, Mukhopadhyay D, Bauri AK, Kumar D, Das P, Chattopadhyay S, Chatterjee M. Malabaricone-A induces a redox imbalance that mediates apoptosis in U937 cell line. PLoS One. 2012; 7(5):e36938.
2. Manna A, De Sarkar S, De S, Bauri AK, Chattopadhyay S, Chatterjee M. The variable chemotherapeutic response of Malabaricone-A in leukemic and solid tumor cell lines depends on the degree of redox imbalance. Phytomedicine. 2015; 22(7-8):713-23.
3. Manna A, Bauri AK, Chattopadhyay S, Chatterjee M. Generation of redox imbalance mediates the cytotoxic effect of Malabaricone-A in a multidrug resistant cell line. Anticancer Agents in Medicinal Chemistry. 2015; 15(9):1156-63.
4. Manna A, De Sarkar S, De S, Bauri AK, Chattopadhyay S, Chatterjee M. Impact of MAPK and PI3K/AKT signaling pathways on Malabaricone-A induced cytotoxicity in U937, a histiocytic lymphoma cell line. Int Immunopharmacol. 2016; 39: 34-40.
5. Manna A, Chattopadhyay S, Chatterjee M. Plant derived pro-oxidants as potential anti-cancer therapeutics. Studies in Natural Products Chemistry. 2016; 50: 81-129.
6. Paulus A#, Manna A#, Akhtar S, Paulus SM, Sharma M, Coignet MV, Jiang L, Roy V, Witzig TE, Ansell SM, Allan J, Furman R, Aulakh S, Manochakian R, Ailawadhi S, Chanan-Khan AA, Sher T. Targeting CD38 with daratumumab is lethal to Waldenström macroglobulinaemia cells. Br J Haematol. 2018. doi: 10.1111/bjh.15515. (In press; equal contribution).
7. De S, Manna A, Kundu S, De Sarkar S, Chatterjee U, Sen T, Chattopadhyay S, Chatterjee M. Allylpyrocatechol Attenuates Collagen-Induced Arthritis via Attenuation of Oxidative Stress Secondary to Modulation of the MAPK, JAK/STAT, and Nrf2/HO-1 Pathways. J Pharmacol Exp Ther. 2017; 360(2):249-259.
8. Mukhopadhyay D, Das NK, De Sarkar S, Manna A, Ganguly DN, Barbhuiya JN, Maitra AK, Hazra A, Chatterjee M. Evaluation of serological markers to monitor the disease status of Indian post kala-azar dermal leishmaniasis. Trans R Soc Trop Med Hyg. 2012; 106(11): 668-76.
9. Chatterjee S, Das S, Chakraborty P, Manna A, Chatterjee M, Choudhuri SK. Myeloid derived suppressor cells (MDSCs) can induce the generation of Th17 response from naïve CD4+ T cells. Immunobiology. 2013; 218(5): 718-24.
10. Sarkar D, Kundu S, De S, Hariharan C, Saha P, Manna A, Chattopadhyay S, Chatterjee M. The antioxidant activity of allylpyrocatechol is mediated via decreased generation of free radicals along with escalation of antioxidant mechanisms. Phytother Res. 2013; 27(3): 324-9.
11. Kumar D, Das B, Sen R, Kundu P, Manna A, Sarkar A, Chowdhury C, Chatterjee M, Das P. Andrographolide Analogue Induces Apoptosis and Autophagy Mediated CellDeath in U937 Cells by Inhibition of PI3K/Akt/mTOR Pathway. PLoS One. 2015; 10(10): e0139657.
12. Mitra S, Pati AK, Manna A, Ghosh A, Sen S, Chatterjee S, Chatterjee M. A study of the free radical scavenging effects of Piper betle leaf extract in patients with vitiligo. Indian J Dermatol Venereol Leprol. 2017; 83(1):40-46.
13. Paulus A, Akhtar S, Yousaf H, Manna A, Paulus SM, Bashir Y, Caulfield TR, Kuranz-Blake M, Chitta K, Wang X, Asmann Y, Hudec R, Springer W, Ailawadhi S, Chanan-Khan A. Waldenstrom macroglobulinemia cells devoid of BTK(C481S) or CXCR4(WHIM-like) mutations acquire resistance to ibrutinib through upregulation of Bcl-2 and AKT resulting in vulnerability towards venetoclax or MK2206 treatment. Blood Cancer J. 2017; 7(5):e565.
14. Datta S, Dasgupta D, Ghosh A, Ghosh S, Manna A, Datta S, Chatterjee M, Chowdhury A, Banerjee S. Oncogenic potential of hepatitis B virus subgenotype D1 surpasses D3: significance in the development of hepatocellular carcinoma. Carcinogenesis. 2018; 39(2):283-292.
15. Laali KL, Greves W, Correa-Smits SJ, Zwarycz AT, Bunge SD, Borosky GL, Manna A, Paulus A, Chanan-Khan A. Novel Fluorinated Curcuminoids and their Pyrazole and Isoxazole Derivatives: Synthesis, Structural Studies, Computational/Docking and in-vitro Bioassay. Journal of Fluorine Chemistry. 2018; 206; 82-98.
16. Laali KK, Greves WJ, Zwarycz AT, Correa Smits SJ, Troendle FJ, Borosky GL, Akhtar S, Manna A, Paulus A, Chanan-Khan A, Nukaya M, Kennedy GD. Synthesis, Computational Docking Study, and Biological Evaluation of a Library of Heterocyclic Curcuminoids with Remarkable Antitumor Activity. ChemMedChem. 2018. doi: 10.1002/cmdc.201800320. (In press).
参审 protocol 2篇
Collagenase-based Single Cell Isolation of Primary Murine Brain Endothelial Cells Using Flow Cytometry
利用流式细胞技术进行原代小鼠脑内皮细胞的基于胶原酶的单细胞分离
作者:Cathrin J. Czupalla, Hanadie Yousef, Tony Wyss-Coray and Eugene C. Butcher日期:11/20/2018,浏览量:7653,Q&A: 0
The brain endothelium is a highly specialized vascular structure that maintains the activity and integrity of the central nervous system (CNS). Previous studies have reported that the integrity of the brain endothelium is compromised in a plethora ...
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Generation of Human Mesenchymal Stem Cell 3D Spheroids Using Low-binding Plates
利用低结合培养板培养产生人间充质干细胞3D球状体
The 3D culture of human mesenchymal stem cells (hMSCs) represents a more physiological environment than classical 2D culture and has been used to enhance the MSC secretome or extend cell survival after transplantation. Here we describe a simple and ...
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主审 protocol 3篇
Tyramide Signal-Amplified Immunofluorescence of MYCN and MYC in Human Tissue Specimens and Cell Line Cultures
酪胺信号放大的人体组织标本和细胞系培养物中的MYCN和MYC免疫荧光
作者:Johanna M. Schafer and Jennifer A. Pietenpol日期:07/05/2020,浏览量:1788,Q&A: 0
MYC family members, MYC, MYCN, and MYCL, are oncogenic transcription factors that regulate the expression of genes involved in normal development, cell growth, proliferation, metabolism, and survival. While MYC is amplified and/or overexpressed ...
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Reconstituting Breast Tissue with Organotypic Three-dimensional Co-culture of Epithelial and Stromal Cells in Discontinuous Extracellular Matrices
通过不连续细胞外基质中上皮细胞和基质细胞三维共培养重建乳腺组织
作者:Gang Ren, Vandana Sharma, Joshua Letson, Yashna Walia, Veani Fernando and Saori Furuta日期:10/05/2019,浏览量:2605,Q&A: 0
Co-culture systems utilizing reconstituted or synthetic extracellular matrix (ECM) and micropatterning techniques have enabled the reconstruction of surface epithelial tissues. This technique has been utilized in the regeneration, disease modeling ...
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