联合作者(
Johan Neyts KU Leuven – University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Belgium
4 protocols

Kai Dallmeier Microbiology and Immunology Department, University of Leuven, Belgium
2 protocols
联合评审(
Anca Flavia Savulescu University of Cape Town
23 protocols

Angela Corona University of Cagliari
3 protocols

Balaji Olety Amaranath University of Massachusetts medical School
3 protocols

Balasubramanian Venkatakrishnan Syngene International Limited
3 protocols

编委
Yannick Debing
  • Janssen Pharmaceutica
研究方向
  • 微生物学
  • 已发表 protocol 2

Education

Ph.D. in Virology, Rega Institute, University of Leuven, Belgium, 2015

Current position

Postdoctoral fellow, Cardiovascular Research Institute Maastricht, Maastricht University, the Netherlands
Research interests: Hepatitis E virus, antiviral therapy, viral myocarditis

Publications

  1. Dao Thi, V. L., Debing, Y., Wu, X., Rice, C. M., Neyts, J., Moradpour, D. and Gouttenoire, J. (2015). Sofosbuvir inhibits Hepatitis E virus replication in vitro and results in an additive effect when combined with ribavirin. Gastroenterology. (Epub ahead of print)
  2. Debing, Y., Emerson, S. U., Purcell, R. H., Neyts, J. and Dallmeier, K. (2014). Complete genome sequence of a rat hepatitis e virus strain isolated in the United States. Genome Announc 2(6).
  3. Debing, Y., Gisa, A., Dallmeier, K., Pischke, S., Bremer, B., Manns, M., Wedemeyer, H., Suneetha, P. V. and Neyts, J. (2014). A mutation in the hepatitis E virus RNA polymerase promotes its replication and associates with ribavirin treatment failure in organ transplant recipients. Gastroenterology 147(5): 1008-1011 e1007; quiz e1015-1006. 
  4. Debing, Y. and Neyts, J. (2014). mTOR-inhibitors may aggravate chronic hepatitis E. J Hepatol 61(4): 720-722.        
  5. Wang, Y., Zhou, X., Debing, Y., Chen, K., Van Der Laan, L. J., Neyts, J., Janssen, H. L., Metselaar, H. J., Peppelenbosch, M. P. and Pan, Q. (2014). Calcineurin inhibitors stimulate and mycophenolic acid inhibits replication of hepatitis E virus. Gastroenterology 146(7): 1775-1783.
  6. Debing, Y. and Neyts, J. (2014). Antiviral strategies for hepatitis E virus. Antiviral Res 102: 106-118.
  7. Debing, Y., Emerson, S. U., Wang, Y., Pan, Q., Balzarini, J., Dallmeier, K. and Neyts, J. (2014). Ribavirin inhibits in vitro hepatitis E virus replication through depletion of cellular GTP pools and is moderately synergistic with alpha interferon. Antimicrob Agents Chemother 58(1): 267-273.
  8. Rocha-Pereira, J., Jochmans, D., Debing, Y., Verbeken, E., Nascimento, M. S. and Neyts, J. (2013). The viral polymerase inhibitor 2'-C-methylcytidine inhibits Norwalk virus replication and protects against norovirus-induced diarrhea and mortality in a mouse model. J Virol 87(21): 11798-11805.
  9. Debing, Y., Winton, J., Neyts, J. and Dallmeier, K. (2013). Cutthroat trout virus as a surrogate in vitro infection model for testing inhibitors of hepatitis E virus replication. Antiviral Res 100(1): 98-101.
  10. Debing, Y., Neyts, J. and Thibaut, H. J. (2013). Molecular Biology and Inhibitors of Hepatitis A Virus. Med Res Rev.
  11. Chatelain, G., Debing, Y., De Burghgraeve, T., Zmurko, J., Saudi, M., Rozenski, J., Neyts, J. and Van Aerschot, A. (2013). In search of flavivirus inhibitors: evaluation of different tritylated nucleoside analogues. Eur J Med Chem 65: 249-255.
  12. Debing, Y., Jochmans, D. and Neyts, J. (2013). Intervention strategies for emerging viruses: use of antivirals. Curr Opin Virol 3(2): 217-224.
  13. Debing, Y., Kaplan, G. G., Neyts, J. and Jochmans, D. (2013). Rapid and convenient assays to assess potential inhibitory activity on in vitro hepatitis A replication. Antiviral Res 98(2): 325-331.
  14. De Burghgraeve, T., Selisko, B., Kaptein, S., Chatelain, G., Leyssen, P., Debing, Y., Jacobs, M., Van Aerschot, A., Canard, B. and Neyts, J. (2013). 3',5'Di-O-trityluridine inhibits in vitro flavivirus replication. Antiviral Res 98(2): 242-247.
已发表 protocol 2篇
Luminescence-based Antiviral Assay for Hepatitis E Virus
针对戊型肝炎病毒的发光抗病毒物质试验

作者:Yannick Debing, Kai Dallmeier and Johan Neyts日期:08/05/2014,浏览量:8284,Q&A: 0
Hepatitis E virus (HEV) is one of the main causes of acute hepatitis worldwide. Infections are particularly severe in pregnant women and chronic hepatitis E is known to occur in immunocompromised patients. Current therapy (ribavirin or pegylated ...
Infectious Virus Yield Assay for Hepatitis E Virus
戊型肝炎病毒的感染病毒产量分析

作者:Yannick Debing, Kai Dallmeier and Johan Neyts日期:08/05/2014,浏览量:8772,Q&A: 0
Hepatitis E virus (HEV) is one of the main causes of acute hepatitis worldwide. Infections are particularly severe in pregnant women and chronic hepatitis E is known to occur in immunocompromised patients. Current therapy (ribavirin or pegylated ...
参审 protocol 3篇
Measurement of 2-methylthio Modifications in Mitochondrial Transfer RNAs by Reverse-transcription Quantitative PCR
反转录定量聚合酶链反应(qRT-PCR)法测量线粒体转运RNA中的2-甲硫基修饰
作者:Fan-Yan Wei and Kazuhito Tomizawa日期:01/05/2016,浏览量:6810,Q&A: 0
2-Methylthio-N6-isopentenyladenosine (ms2i6A) is an evolutionally conserved posttranscriptional modification found at position 37 of four mammalian mitochondrial tRNAs, mt-tRNASer(UCN), mt-tRNATrp ...
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Introduction and Sequencing of Patient-isolated HBV RT Sequences into the HBV 1.2-mer Replicon
把亲体分离的HBV RT序列引入HBV 1.2-mer复制子中并测序
作者:Sung Hyun Ahn, Yong Kwang Park and Kyun-Hwan Kim日期:04/20/2015,浏览量:7456,Q&A: 0
Antiviral agents for the suppression of hepatitis B virus (HBV) have been used for treating chronic hepatitis B. However, the emergence of drug-resistant HBV is still a major problem for antiviral treatment. To identify and characterize the ...
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主审 protocol 24篇
Sleeping Beauty Transposon-based System for Rapid Generation of HBV-replicating Stable Cell Lines
使用基于睡美人转座子的系统快速生成HBV复制稳定细胞系
作者:Jin-Wei Zheng, Jia-Li Cao and Quan Yuan 日期:07/05/2018,浏览量:5920,Q&A: 0
The stable HBV-transfected cell lines, which based on stable integration of replication-competent HBV genome into hepatic cells, are widely used in basic research and antiviral drug evaluation against HBV. However, previous reported strategies to ...
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Assessing the Efficacy of Small Molecule Inhibitors in a Mouse Model of Persistent Norovirus Infection
小分子抑制剂在持续性诺如病毒感染小鼠模型中的疗效评估
作者:Jana Van Dycke, Johan Neyts and Joana Rocha-Pereira日期:05/05/2018,浏览量:4405,Q&A: 0
Human norovirus is the most common cause of acute gastroenteritis worldwide, resulting in estimated mortality of ~210,000 each year, of whom most are children under the age of five. However, norovirus can infect people of all age groups. There is a ...
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