癌症生物学

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    现刊
    Reconstruction of Human AML Using Functionally and Immunophenotypically Defined Human Haematopoietic Stem and Progenitor Cells as Targeted Populations
    使用功能和免疫表型定义的人类造血干细胞和祖细胞重建人类急性髓细胞白血病模型
    作者:Bernd B. Zeisig, Tsz Kan Fung, Estelle Troadec and Chi Wai Eric So日期:12/20/2021,浏览量:1786,Q&A: 0
    [Abstract]

    Acute myeloid leukaemia (AML) is a highly heterogenous blood cancer, in which the expansion of aberrant myeloid blood cells interferes with the generation and function of normal blood cells. Although key driver mutations and their associated inhibitors have been identified in the last decade, they have not been fully translated into better

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    Modeling NOTCH1 driven T-cell Acute Lymphoblastic Leukemia in Mice
    NOTCH1诱导小鼠T细胞急性淋巴细胞白血病模型的建立
    作者:Agnieszka A. Wendorff and Adolfo A. Ferrando日期:05/20/2020,浏览量:3655,Q&A: 0
    [Abstract] T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy that arises from transformation of T-cell primed hematopoietic progenitors. Although T-ALL is a heterogenous and molecularly complex disease, more than 65% of T-ALL patients carry activating mutations in the NOTCH1 gene. The majority of T-ALL–associated ...
    In vivo Leukemogenesis Model Using Retrovirus Transduction
    采用逆转录病毒转导的体内白血病生成模型
    作者:Hiroshi Okuda and Akihiko Yokoyama日期:12/05/2017,浏览量:7727,Q&A: 0
    [Abstract] Various genetic alterations such as chromosomal translocation cause leukemia. For examples, gene rearrangements of the mixed-lineage leukemia (MLL) gene generate MLL fusion genes, whose products are potent oncogenic drivers in acute leukemia. To better understand the mechanism of disease onset, several murine leukemia models ...