神经科学

分类

    现刊
    A Simple Spatial-independent Associative and Reversal Learning Task in Mice
    小鼠的一个简单的空间独立的联想和逆转学习任务
    作者:Fulvio Magara, Benjamin Boury-Jamot and Hanna Hörnberg日期:08/05/2021,浏览量:563,Q&A: 0
    [Abstract]

    The ability to adapt one's behavior in response to changing circumstances, or cognitive flexibility, is often altered in neuropsychiatric and neurodevelopmental conditions. In rodents, cognitive flexibility is frequently assessed using associative learning paradigms with a reversal component. The majority of existing protocols rely on

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    Ethanol-induced Sedative Behavior: An Assay to Investigate Increased Dopamine Signaling in Caenorhabditis elegans
    乙醇诱导的镇静行为:一项在秀丽隐杆线虫研究增加多巴胺信号
    作者:Anuradha Singh, Kavita Babu and Pratima Pandey日期:07/05/2021,浏览量:889,Q&A: 0
    [Abstract]

    Dopamine (DA) signaling affects locomotion, feeding, learning, and memory in C. elegans. Various assays have been developed to study the proteins involved in these behaviors; however, these assays show behavioral output only when there is a drastic change in DA levels. We designed an assay capable of observing behavioral output even with only

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    In vivo Optical Access to Olfactory Sensory Neurons in the Mouse Olfactory Epithelium
    小鼠嗅上皮嗅觉感觉神经元的体内光学通路研究
    作者:Shigenori Inagaki, Ryo Iwata and Takeshi Imai日期:06/20/2021,浏览量:1223,Q&A: 0
    [Abstract]

    In neuroscience, it is fundamental to understand how sensory stimuli are translated into neural activity at the entry point of sensory systems. In the olfactory system, odorants inhaled into the nasal cavity are detected by ~1,000 types of odorant receptors (ORs) that are expressed by olfactory sensory neurons (OSNs). Since each OSN expresses only

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    Operant Vapor Self-administration in Mice
    小鼠蒸汽吸入自我给药操作
    作者:Renata C. N. Marchette, Brendan J. Tunstall, Leandro F. Vendruscolo and Khaled Moussawi日期:05/20/2021,浏览量:1154,Q&A: 0
    [Abstract]

    Models of drug addiction in rodents are instrumental in understanding the underlying neurobiology. Intravenous self-administration of drugs in mice is currently the most commonly used model; however, several challenges exist due to complications related to catheter patency. To take full advantage of the genetic tools available to study opioid

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    A Time Duration Discrimination Task for the Study of Elapsed Time Processing in Rats
    用于研究大鼠执行时间的时程辨别任务
    [Abstract]

    Space and time are both essential features of episodic memory. However, while spatial tasks have been used effectively to study the behavioral relevance of place cells, the behavioral paradigms utilized for the study of time cells have not used time duration as a variable that animals need to be aware of to solve the task. In order to evaluate how

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    Dissociating Behavior and Spatial Working Memory Demands Using an H Maze
    利用H迷宫研究分离行为和空间工作记忆需求
    作者:Hannah S. Wirtshafter, Moqing Quan and Matthew A. Wilson日期:03/05/2021,浏览量:1164,Q&A: 0
    [Abstract]

    The development of mazes for animal experiments has allowed for the investigation of cognitive maps and place cells, spatial working memory, naturalistic navigation, perseverance, exploration, and choice and motivated behavior. However, many mazes, such as the T maze, currently developed to test learning and memory, do not distinguish temporally

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    Calcium Imaging of Neuronal Activity under Gradually Changing Odor Stimulation in Caenorhabditis elegans
    渐变气味刺激下秀丽隐杆线虫神经元活动的钙成像
    作者:Yuki Tanimoto and Koutarou D. Kimura日期:01/05/2021,浏览量:1418,Q&A: 0
    [Abstract]

    Olfactory behavior is among the most fundamental animal behaviors both in the wild and in the laboratory. To elucidate the neural mechanisms underlying olfactory behavior, it is critical to measure neural responses to odorant concentration changes resembling those that animals actually sense during olfactory behavior. However, reproducing the

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    Treadmill Running of Mouse as a Model for Studying Influence of Maternal Exercise on Offspring
    以跑步机运动小鼠为模型研究母体运动对后代的影响
    作者:Song Ah Chae, Jun Seok Son, Mei-Jun Zhu, Jeanene M. de Avila and Min Du日期:12/05/2020,浏览量:1550,Q&A: 0
    [Abstract]

    Epidemiological studies robustly show the beneficial effects of maternal exercise in reducing maternal birth complications and improving neonatal outcomes, though underlying mechanisms remain poorly understood. To facilitate mechanistic exploration, a protocol for maternal exercise of mice is established, with the regimen following the exercise

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    Visual-looming Shadow Task with in-vivo Calcium Activity Monitoring to Assess Defensive Behaviors in Mice
    视觉变化阴影任务结合体内钙离子活性监测评估小鼠防御行为
    作者:Nuria Daviu, Tamas Fuzesi, David G.Rosenegger, Govind Peringod, Kathryn Simone and Jaideep S. Bains日期:11/20/2020,浏览量:1561,Q&A: 0
    [Abstract] There has been a clear movement in recent years towards the adoption of more naturalistic experimental regimes for the study of behavior and its underlying neural architecture. Here we provide a protocol that allows experimenters working with mice, to mimic a looming and advancing predatory threat from the sky. This approach is easy to implement ...
    An Operant Conditioning Model Combined with a Chemogenetic Approach to Study the Neurobiology of Food Addiction in Mice
    操作式条件反射模型结合化学遗传学方法研究小鼠食物成瘾的神经生物学机制
    作者:Elena Martín-García, Laura Domingo-Rodriguez and Rafael Maldonado日期:10/05/2020,浏览量:1767,Q&A: 0
    [Abstract] The study of food addiction comprises 3 hallmarks that include the persistence to response without an outcome, the strong motivation for palatable food, and the loss of inhibitory control over food intake that leads to compulsive behavior in addicted individuals. The complex multifactorial nature of this disorder and the unknown neurobiological ...