癌症生物学

分类

    现刊
    A Robust Mammary Organoid System to Model Lactation and Involution-like Processes
    一个健康的乳腺有机样系统来模拟哺乳和退化样过程
    作者:Elsa Charifou, Jakub Sumbal, Zuzana Koledova, Han Li and Aurélie Chiche日期:04/20/2021,浏览量:2407,Q&A: 0
    [Abstract]

    The mammary gland is a highly dynamic tissue that changes throughout reproductive life, including growth during puberty and repetitive cycles of pregnancy and involution. Mammary gland tumors represent the most common cancer diagnosed in women worldwide. Studying the regulatory mechanisms of mammary gland development is essential for understanding

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    Preparation of an Orthotopic, Syngeneic Model of Lung Adenocarcinoma and the Testing of the Antitumor Efficacy of Poly(2-oxazoline) Formulation of Chemo-and Immunotherapeutic Agents
    肺腺癌原位同源模型的制备及聚恶唑啉化疗和免疫治疗药物抗肿瘤疗效的测定
    [Abstract]

    Tumor xenograft models developed by transplanting human tissues or cells into immune-deficient mice are widely used to study human cancer response to drug candidates. However, immune-deficient mice are unfit for investigating the effect of immunotherapeutic agents on the host immune response to cancer (Morgan, 2012). Here, we describe the

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    In vivo Tumor Growth and Spontaneous Metastasis Assays Using A549 Lung Cancer Cells
    利用A549肺癌细胞进行肿瘤生长和自发性转移的体内检测
    作者:Lei Qi, Teresa Knifley, Dava W. Piecoro, Piotr Rychahou, Jianrong Wu, Kathleen L. O’Connor and Min Chen日期:04/05/2020,浏览量:3129,Q&A: 0
    [Abstract] Metastasis accounts for the majority of cancer related deaths. The genetically engineered mouse (GEM) models and cell line-based subcutaneous and orthotopic mouse xenografts have been developed to study the metastatic process. By using lung cancer cell line A549 as an example, we present a modified protocol to establish the cell line-based ...
    In vivo Leukemogenesis Model Using Retrovirus Transduction
    采用逆转录病毒转导的体内白血病生成模型
    作者:Hiroshi Okuda and Akihiko Yokoyama日期:12/05/2017,浏览量:6626,Q&A: 0
    [Abstract] Various genetic alterations such as chromosomal translocation cause leukemia. For examples, gene rearrangements of the mixed-lineage leukemia (MLL) gene generate MLL fusion genes, whose products are potent oncogenic drivers in acute leukemia. To better understand the mechanism of disease onset, several murine leukemia models ...
    Xenograft Mouse Model of Human Uveal Melanoma
    人葡萄膜黑色素瘤异种移植小鼠模型
    作者:Yao Chen, Xiao Liu, Ling Gao and Yongqing Liu日期:11/05/2017,浏览量:5846,Q&A: 0
    [Abstract] Uveal melanoma (UM) is a malignant intraocular tumor in adults. Metastasis develops in almost half of the patients and over 90% of the metastases are in the liver. With the advances in molecular targeting therapy for melanoma, a proper metastasis animal model is of increasing importance for testing the accuracy and effectiveness of systemic ...
    Glioma Induction by Intracerebral Retrovirus Injection
    脑内注射逆转录病毒诱导胶质瘤
    作者:Ravinder K Verma , Fanghui Lu and Qing Richard Lu日期:07/20/2017,浏览量:7187,Q&A: 0
    [Abstract] Glioblastoma (GBM) is the most common primary brain cancer in adults and has a poor prognosis. It is characterized by a high degree of cellular infiltration that leads to tumor recurrence, atypical hyperplasia, necrosis, and angiogenesis. Despite aggressive treatment modalities, current therapies are ineffective for GBM. Mouse GBM models not only ...
    A Novel Mouse Skin Graft Model of Vascular Tumors Driven by Akt1
    由Akt1驱动的血管肿瘤的新型小鼠皮肤移植模型
    作者:Thuy L. Phung and Sriram Ayyaswamy日期:07/05/2017,浏览量:8446,Q&A: 0
    [Abstract] To investigate whether endothelial Akt1 activation is sufficient to induce vascular tumor formation in the skin, we have developed a skin graft model in which a skin fragment from transgenic donor mice with inducible and endothelial cell-specific overexpression of activated Akt1 (myrAkt1) is grafted into the skin of wild type recipient mice. The ...
    Intracaecal Orthotopic Colorectal Cancer Xenograft Mouse Model
    脑内原位结直肠癌异种移植小鼠模型
    作者:Hsin-Wei Liao and Mien-Chie Hung日期:06/05/2017,浏览量:10257,Q&A: 1
    [Abstract] The host microenvironment plays a prominent role in tumor growth, angiogenesis, invasion, metastasis, and response to therapy. Orthotopic tumor model mimics the natural environment of tumor development and provides an effective approach to investigate tumor pathophysiology and develop therapeutic strategies. This protocol describes the technique ...
    Pituitary Isograft Transplantation in Mice
    小鼠垂体同系移植物移植
    作者:Chance Walker, Yan Hong, Frances Kittrell, Daniel Medina, David Edwards and Fariba Behbod日期:06/05/2017,浏览量:6270,Q&A: 0
    [Abstract] The mouse pituitary isograft is a technique developed to administer persistent hormone stimulation, thereby increasing cellular proliferation in the mammary tissue (Christov et al., 1993). The pituitary isograft procedure was first described in ‘Induction of Mammary Cancer in Mice without the Mammary Tumor Agent by Isografts of ...
    High Fat Diet-induced Breast Cancer Model in Rat
    高脂饮食诱导的大鼠乳腺癌模型
    作者:Meng Ju Wu and Chun Ju Chang日期:07/05/2016,浏览量:6392,Q&A: 0
    [Abstract] Obesity has been linked to breast cancer progression but the underlying mechanisms remain obscure. Being overweight or obese for a woman at the time she is diagnosed with breast cancer is linked to a high risk of recurrence regardless of treatment factors. In rodents, high body weight is also associated with increased incidence of spontaneous and ...