Miao He
  • Principal Investigator, Institutes of Brain Science Fudan University
  • Neuroscience


PhD, State University of New York at Stony Brook, 2011


Miao He Lab


Neuronal diversity
Genetic targeting
Neural circuit


• Xiao X, Deng H, Furlan A, Yang T, Zhang X, Hwang GR, Tucciarone J, Wu P, He M, Palaniswamy R, Ramakrishnan C, Ritola K, Hantman A, Deisseroth K, Osten P, Huang ZJ, Li B*. A Genetically Defined Compartmentalized Striatal Direct Pathway for Negative Reinforcement. Cell. 2020 Sep 10:S0092-8674(20)31074-6. doi: 10.1016/j.cell.2020.08.032. Online ahead of print. PMID: 32937106

• Yang WZ, Du X, Zhang W, Gao C, Xie H, Xiao Y, Jia X, Liu J, Xu J, Fu X, Tu H, Fu X, Ni X, He M, Yang J, Wang H, Yang H, Xu XH, Shen WL. Parabrachial neuron types categorically encode thermoregulation variables during heat defense. Sci Adv. 2020 Sep 2;6(36):eabb9414. doi: 10.1126/sciadv.abb9414. Print 2020 Sep.

• Liu L, Xu H, Wang J, Li J, Tian Y, Zheng J, He M, Xu TL, Wu ZY, Li XM, Duan SM, Xu H. Cell type-differential modulation of prefrontal cortical GABAergic interneurons on low gamma rhythm and social interaction.Sci Adv. 2020 Jul 22;6(30):eaay4073. doi: 10.1126/sciadv.aay4073. eCollection 2020 Jul.

• Liu X, Ma L, Liu H, Gan J, Xu Y, Zhang T, Mu P, Wu J, Shi Y, Zhang Y, Gong L, He M*. Cell-type-specific gene inactivation and in situ restoration via recombinase-based flipping of targeted genomic region. J Neurosci. 2020 Sep 9;40(37):7169-7186.doi: 10.1523/JNEUROSCI.1044-20.2020. (Research Spotlight)

• Zhu T, Zhao Y, Zhang P, Shao Y, He J, Xue P, Zheng W, Qu W, Jia X, Zhou Z, Lu R, He M, Zhang Y*. Lead impairs the development of innate lymphoid cells by impeding the differentiation of their progenitors. Toxicol Sci. 2020 May 19:kfaa074. doi: 10.1093/toxsci/kfaa074. Online ahead of print. PMID: 32428222

• Zhang Y, Liu G, Guo T, Liang XG, Du H, Yang L, Bhaduri A, Li X, Xu Z, Zhang Z, Li Z, He M, Tsyporin J, Kriegstein AR, Rubenstein JL, Yang Z*, Chen B*. Cortical Neural Stem Cell Lineage Progression Is Regulated by Extrinsic Signaling Molecule Sonic Hedgehog. Cell Rep. 2020 Mar 31;30(13):4490-4504.e4.

• Cong W, Shi Y, Qi Y, Wu J, Gong L, He M*. Viral approaches to study the mammalian brain: Lineage tracing, circuit dissection and therapeutic applications. J Neurosci Methods. 2020 Apr 1;335:108629.

• Qiu F., Mao X., Liu P., Wu J., Zhang Y., Sun D., Zhu Y., Gong L., Shao M., Fan K., Chen J., Lu J., Jiang Y., Zhang Y., Curia G., Li A., He M*. microRNA deficiency in VIP+ interneurons leads to cortical circuit dysfunction. Cerebral Cortex 2020 Apr;30(1): 2229–2249, https://doi.org/10.1093/cercor/bhz236

• Chen Z., Yuan X., Dong H., Wu Y., Chen G., He M, Qu W., Huang Z.(2019) Whole-brain neural connectivity to lateral pontine tegmentum GABAergic neurons in mice. Frontiers in Neuroscience, 2019 Apr 24;13:375. doi: 10.3389/fnins.2019.00375.

• Cai Z., Wang G., Chen Y. and He M. (2018). Caesarean Sectioning and Cross-Fostering of the Mouse . Bio-protocol Bio101: e3085. DOI: 10.21769/BioProtoc.3085.

• Kelly SM, Raudales R, He M, Lee JH, Kim Y, Gibb LG, Wu P, Matho K, Osten P, Graybiel AM, Huang ZJ. Radial Glial Lineage Progression and Differential Intermediate Progenitor Amplification Underlie Striatal Compartments and Circuit Organization. Neuron. 2018 Jul 25;99(2):345-361.e4. doi: 10.1016/j.neuron.2018.06.021. Epub 2018 Jul 12.

• Luo SX, Huang J, Li Q, Mohammad H, Lee CY, Krishna K, Kok AM, Tan YL, Lim JY, Li H, Yeow LY, Sun J, He M, Grandjean J, Sajikumar S, Han W, Fu Y. Regulation of feeding by somatostatin neurons in the tuberal nucleus. Science. 2018 Jul 6;361(6397):76-81. doi: 10.1126/science.aar4983.

• Zhao Y, Li Q, Yang Z, Shao Y, Xue P, Qu W, Jia X, Cheng L, He M, He R, Zhou Z, Zhang Y.Cadmium activates non-canonical Wnt signaling to impair hematopoietic stem cell function in mice. Toxicol Sci. 2018 Jun 25. doi: 10.1093/toxsci/kfy166. [Epub ahead of print]

• Li Q, Yang Z, Zhang P, Zhao Y, Yu X, Xue P, Shao Y, Li Q, Jia X, Zhang Q, Cheng L, He M, Zhou Z, Zhang Y. Mercury impact on hematopoietic stem cells is regulated by IFNγ-dependent bone marrow-resident macrophages in mice. Toxicol Lett. 2018 May 31;295:54-63. doi: 10.1016/j.toxlet.2018.05.037. [Epub ahead of print]

• He, M., Huang, ZJ. Genetic approaches to access cell types in mammalian nervous systems. Curr Opin Neurobiol. 2018 Feb 19;50:109-118. doi: 10.1016/j.conb.2018.02.003.

• Schiff, H.C., Bouhuis, A.,Yu, K., Penzo, M.A., Li, H., He, M., Li, B. An Insula-Central Amygdala Circuit for Guiding Tastant-Reinforced Choice Behavior., J Neurosci., 2018.2.7, 38(6): 1418~1429

• Yu, K., Ahrens S., Zhang X., Schiff H., Ramakrishnan C., Fenno L., Deisseroth K., Zhao F., Luo M. H., Gong L., He M., Zhou P., Paninski L., Li B. The central amygdala controls learning in the lateral amygdala. Nat Neurosci 2017; 20(12): 1680-1685.

• Paul, A., Crow M., Raudales R., He M., Gillis J., Huang Z. J. Transcriptional architecture of synaptic communication delineates gabaergic neuron identity. Cell 2017; 171(3): 522-539 e520.

• Kim, Y., Yang G. R., Pradhan K., Venkataraju K. U., Bota M., Garcia Del Molino L. C., Fitzgerald G., Ram K., He M., Levine J. M., Mitra P., Huang Z. J., Wang X. J., Osten P. Brain-wide maps reveal stereotyped cell-type-based cortical architecture and subcortical sexual dimorphism. Cell 2017; 171(2): 456-469 e422.

• Lu, J., Tucciarone J., Padilla-Coreano N., He M., Gordon J. A., Huang Z. J. Selective inhibitory control of pyramidal neuron ensembles and cortical subnetworks by chandelier cells. Nat Neurosci 2017; 20(10): 1377-1383.

• Li, J., Wang C., Zhang Z., Wen Y., An L., Liang Q., Xu Z., Wei S., Li W., Guo T., Liu G., Tao G., You Y., Du H., Fu Z., He M., Chen B., Campbell K., Alvarez-Buylla A., Rubenstein J. L., Yang Z. Transcription factors sp8 and sp9 coordinately regulate olfactory bulb interneuron development. Cereb Cortex 2017: 1-17.

• Li, Q., Zhang P., Yu X., Zhao Y., Li Q., Zhang Y., Yang Z., Xie Y., Xue P., Sun S., Jia X., Zhou Z., He M., Zhang Y. Lead transiently promotes granulocyte-macrophage progenitor differentiation and subsequently suppresses common myeloid progenitor differentiation. Toxicol Sci 2017.

• He M., Tucciarone J., Lee S., Nigro M. J., Kim Y., Levine J. M., Kelly S. M., Krugikov I., Wu P., Chen Y., Gong L., Hou Y., Osten P., Rudy B., Huang Z. J. Strategies and tools for combinatorial targeting of GABAergic neurons in mouse cerebral cortex. Neuron 2016; 91(6): 1228-1243.

• Zhang, Q., Zhang Y., Wang C., Xu Z., Liang Q., An L., Li J., Liu Z., You Y., He M., Mao Y., Chen B., Xiong Z. Q., Rubenstein J. L., Yang Z. The zinc finger transcription factor sp9 is required for the development of striatopallidal projection neurons. Cell Rep 2016; 16(5): 1431-1444.

• Penzo M.A., Robert V., Tucciarone J., De Bundel D., Wang M., Van Aelst L., Darvas M., Parada L.F., Palmiter R.D., He M., Huang Z.J., Li B. The paraventricular thalamus controls a central amygdala fear circuit. Nature 2015; 519, 455-459.

• Zhou, X., Liu F., Tian M., Xu Z., Liang Q., Wang C., Li J., Liu Z., Tang K., He M., Yang Z. Transcription factors coup-tfi and coup-tfii are required for the production of granule cells in the mouse olfactory bulb. Development 2015; 142(9): 1593-1605.

• Ahrens S., Jaramillo S., Yu K., Ghosh S., Hwang G.R., Paik R., Lai C., He M., Huang Z.J., and Li B. ErbB4 regulation of a thalamic reticular nucleus circuit for sensory selection. Nat Neurosci 2015; 18, 104-111.

• Fenno, L. E., Mattis J., Ramakrishnan C., Hyun M., Lee S. Y., He M., Tucciarone J., Selimbeyoglu A., Berndt A., Grosenick L., Zalocusky K. A., Bernstein H., Swanson H., Perry C., Diester I., Boyce F. M., Bass C. E., Neve R., Huang Z. J., Deisseroth K. Targeting cells with single vectors using multiple-feature boolean logic. Nat Methods 2014; 11(7): 763-772.

• Huang, Z. J., Taniguchi H., He M., Kuhlman S. Cre-dependent adeno-associated virus preparation and delivery for labeling neurons in the mouse brain. Cold Spring Harb Protoc 2014; 2014(2): 190-194.

• Huang, Z. J., Taniguchi H., He M., Kuhlman S. Genetic labeling of neurons in mouse brain. Cold Spring Harb Protoc 2014; 2014(2): 150-160.

• Pfeffer, C. K., Xue M., He M., Huang Z. J., Scanziani M. Inhibition of inhibition in visual cortex: The logic of connections between molecularly distinct interneurons. Nat Neurosci 2013; 16(8): 1068-1076.

• He, M., Liu Y., Wang X., Zhang M. Q., Hannon G. J., Huang Z. J. Cell-type-based analysis of microRNA profiles in the mouse brain. Neuron 2012; 73(1): 35-48.

• Taniguchi, H., He M., Wu P., Kim S., Paik R., Sugino K., Kvitsiani D., Fu Y., Lu J., Lin Y., Miyoshi G., Shima Y., Fishell G., Nelson S. B., Huang Z. J. A resource of cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex. Neuron 2011; 71(6): 995-1013.

• Qin, B., He M., Chen X., Pei D. Sorting nexin 10 induces giant vacuoles in mammalian cells. J Biol Chem 2006; 281(48): 36891-36896.

• Huang Z.J., Taniquchi H., He M., Kuhlman S. (2011). Chapter 13: Genetic Labeling of Neurons in Mouse Brain. Imaging in Developmental Biology: A Laboratory Manual (Book chapter)

Book translation

Innate: How the Wiring of Our Brains Shapes Who We Are by Kevin J. Mitchell (2018) Princeton University Press English to Chinese《天生我材——大脑构筑如何塑造人的个性》; Shanghai Jiaotong University Press (ISBN:9787313227782) (2020)