Ofer Mandelboim
  • The Hebrew University, Israel
  • Cancer biology


Ph.D. in Weizmann Institute of Science, Rehovot, Israel, 1996

Current position

He is a full Professor of Molecular Immunology, the Lautenberg Center for General and Tumor Immunology, the Hebrew University, Hadassah Medical School.

Publications (since 2005)

  1. Tsukerman, P., Stern-Ginossar, N., Gur, C., Glasner, A., Nachmani, D., Bauman, Y., Yamin, R., Vitenshtein, A., Stanietsky, N., Bar-Mag, T., Lankry, D. and Mandelboim, O. (2012). MiR-10b downregulates the stress-induced cell surface molecule MICB, a critical ligand for cancer cell recognition by natural killer cells. Cancer Res 72(21): 5463-5472.
  2. Elias, S. and Mandelboim, O. (2012). Battle of the midgets: innate microRNA networking. RNA Biol 9(6): 792-798..
  3. Glasner, A., Zurunic, A., Meningher, T., Lenac Rovis, T., Tsukerman, P., Bar-On, Y., Yamin, R., Meyers, A. F., Mandeboim, M., Jonjic, S. and Mandelboim, O. (2012). Elucidating the mechanisms of influenza virus recognition by Ncr1. PLoS ONE 7(5): e36837.
  4. Seidel, E., Glasner, A. and Mandelboim, O. (2012). Virus-mediated inhibition of natural cytotoxicity receptor recognition. Cell Mol Life Sci.
  5. Chaushu, S., Wilensky, A., Gur, C., Shapira, L., Elboim, M., Halftek, G., Polak, D., Achdout, H., Bachrach, G. and Mandelboim, O. (2012). Direct recognition of Fusobacterium nucleatum by the NK cell natural cytotoxicity receptor NKp46 aggravates periodontal disease. PLoS Pathog 8(3): e1002601.
  6. Glasner, A., Ghadially, H., Gur, C., Stanietsky, N., Tsukerman, P., Enk, J. and Mandelboim, O. (2012). Recognition and prevention of tumor metastasis by the NK receptor NKp46/NCR1. J Immunol 188(6): 2509-2515.
  7. Manaster, I., Goldman-Wohl, D., Greenfield, C., Nachmani, D., Tsukerman, P., Hamani, Y., Yagel, S. and Mandelboim, O. (2012). MiRNA-mediated control of HLA-G expression and function. PLoS ONE 7(3): e33395.
  8. Ghadially, H., Keynan, Y., Kimani, J., Kimani, M., Ball, T. B., Plummer, F. A., Mandelboim, O. and Meyers, A. F. (2012). Altered dendritic cell-natural killer interaction in Kenyan sex workers resistant to HIV-1 infection. AIDS 26(4): 429-436.
  9. Gur, C., Doron, S., Kfir-Erenfeld, S., Horwitz, E., Abu-Tair, L., Safadi, R. and Mandelboim, O. (2012). NKp46-mediated killing of human and mouse hepatic stellate cells attenuates liver fibrosis. Gut 61(6): 885-893.
  10. Chen, Z., Chen, L., Baker, K., Olszak, T., Zeissig, S., Huang, Y. H., Kuo, T. T., Mandelboim, O., Beauchemin, N., Lanier, L. L. and Blumberg, R. S. (2011). CEACAM1 dampens antitumor immunity by down-regulating NKG2D ligand expression on tumor cells. J Exp Med 208(13): 2633-2640.
  11. Elhaik-Goldman, S., Kafka, D., Yossef, R., Hadad, U., Elkabets, M., Vallon-Eberhard, A., Hulihel, L., Jung, S., Ghadially, H., Braiman, A., Apte, R. N., Mandelboim, O., Dagan, R., Mizrachi-Nebenzahl, Y. and Porgador, A. (2011). The natural cytotoxicity receptor 1 contribution to early clearance of Streptococcus pneumoniae and to natural killer-macrophage cross talk. PLoS ONE 6(8): e23472.
  12. Gur, C., Enk, J., Kassem, S. A., Suissa, Y., Magenheim, J., Stolovich-Rain, M., Nir, T., Achdout, H., Glaser, B., Shapiro, J., Naparstek, Y., Porgador, A., Dor, Y. and Mandelboim, O. (2011). Recognition and killing of human and murine pancreatic beta cells by the NK receptor NKp46. J Immunol 187(6): 3096-3103.
  13. Bauman, Y., Nachmani, D., Vitenshtein, A., Tsukerman, P., Drayman, N., Stern-Ginossar, N., Lankry, D., Gruda, R. and Mandelboim, O. (2011). An identical miRNA of the human JC and BK polyoma viruses targets the stress-induced ligand ULBP3 to escape immune elimination. Cell Host Microbe 9(2): 93-102.
  14. Bauman, Y. and Mandelboim, O. (2011). MicroRNA based immunoevasion mechanism of human polyomaviruses. RNA Biol 8(4): 591-594.
  15. Nachmani, D., Lankry, D., Wolf, D. G. and Mandelboim, O. (2010). The human cytomegalovirus microRNA miR-UL112 acts synergistically with a cellular microRNA to escape immune elimination. Nat Immunol 11(9): 806-813.
  16. Stanietsky, N. and Mandelboim, O. (2010). Paired NK cell receptors controlling NK cytotoxicity. FEBS Lett 584(24): 4895-4900.
  17. Lankry, D., Gazit, R. and Mandelboim, O. (2010). Methods to identify and characterize different NK cell receptors and their ligands. Methods Mol Biol 612: 249-273.
  18. Manaster, I. and Mandelboim, O. (2010). The unique properties of uterine NK cells. Am J Reprod Immunol 63(6): 434-444.
  19. Lankry, D., Simic, H., Klieger, Y., Levi-Schaffer, F., Jonjic, S. and Mandelboim, O. (2010). Expression and function of CD300 in NK cells. J Immunol 185(5): 2877-2886.
  20. Elboim, M., Gazit, R., Gur, C., Ghadially, H., Betser-Cohen, G. and Mandelboim, O. (2010). Tumor immunoediting by NKp46. J Immunol 184(10): 5637-5644.
  21. Betser-Cohen, G., Mizrahi, S., Elboim, M., Alsheich-Bartok, O. and Mandelboim, O. (2010). The association of MHC class I proteins with the 2B4 receptor inhibits self-killing of human NK cells. J Immunol 184(6): 2761-2768.
  22. Mendelson, M., Tekoah, Y., Zilka, A., Gershoni-Yahalom, O., Gazit, R., Achdout, H., Bovin, N. V., Meningher, T., Mandelboim, M., Mandelboim, O., David, A. and Porgador, A. (2010). NKp46 O-glycan sequences that are involved in the interaction with hemagglutinin type 1 of influenza virus. J Virol 84(8): 3789-3797.
  23. Achdout, H., Meningher, T., Hirsh, S., Glasner, A., Bar-On, Y., Gur, C., Porgador, A., Mendelson, M., Mandelboim, M. and Mandelboim, O. (2010). Killing of avian and Swine influenza virus by natural killer cells. J Virol 84(8): 3993-4001.
  24. Gonen-Gross, T., Goldman-Wohl, D., Huppertz, B., Lankry, D., Greenfield, C., Natanson-Yaron, S., Hamani, Y., Gilad, R., Yagel, S. and Mandelboim, O. (2010). Inhibitory NK receptor recognition of HLA-G: regulation by contact residues and by cell specific expression at the fetal-maternal interface. PLoS ONE 5(1): e8941.
  25. Gur, C., Porgador, A., Elboim, M., Gazit, R., Mizrahi, S., Stern-Ginossar, N., Achdout, H., Ghadially, H., Dor, Y., Nir, T., Doviner, V., Hershkovitz, O., Mendelson, M., Naparstek, Y. and Mandelboim, O. (2010). The activating receptor NKp46 is essential for the development of type 1 diabetes. Nat Immunol 11(2): 121-128.
  26. Manaster, I., Gazit, R., Goldman-Wohl, D., Stern-Ginossar, N., Mizrahi, S., Yagel, S. and Mandelboim, O. (2010). Notch activation enhances IFNgamma secretion by human peripheral blood and decidual NK cells. J Reprod Immunol 84(1): 1-7.
  27. Satoh-Takayama, N., Dumoutier, L., Lesjean-Pottier, S., Ribeiro, V. S., Mandelboim, O., Renauld, J. C., Vosshenrich, C. A. and Di Santo, J. P. (2009). The natural cytotoxicity receptor NKp46 is dispensable for IL-22-mediated innate intestinal immune defense against Citrobacter rodentium. J Immunol 183(10): 6579-6587.
  28. Stern-Ginossar, N. and Mandelboim, O. (2009). An integrated view of the regulation of NKG2D ligands. Immunology 128(1): 1-6.
  29. Stanietsky, N., Simic, H., Arapovic, J., Toporik, A., Levy, O., Novik, A., Levine, Z., Beiman, M., Dassa, L., Achdout, H., Stern-Ginossar, N., Tsukerman, P., Jonjic, S. and Mandelboim, O. (2009). The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. Proc Natl Acad Sci U S A 106(42): 17858-17863.
  30. Beuneu, H., Deguine, J., Breart, B., Mandelboim, O., Di Santo, J. P. and Bousso, P. (2009). Dynamic behavior of NK cells during activation in lymph nodes. Blood 114(15): 3227-3234.
  31. Stern-Ginossar, N., Saleh, N., Goldberg, M. D., Prichard, M., Wolf, D. G. and Mandelboim, O. (2009). Analysis of human cytomegalovirus-encoded microRNA activity during infection. J Virol 83(20): 10684-10693.
  32. Nachmani, D., Stern-Ginossar, N., Sarid, R. and Mandelboim, O. (2009). Diverse herpesvirus microRNAs target the stress-induced immune ligand MICB to escape recognition by natural killer cells. Cell Host Microbe 5(4): 376-385.
  33. Halfteck, G. G., Elboim, M., Gur, C., Achdout, H., Ghadially, H. and Mandelboim, O. (2009). Enhanced in vivo growth of lymphoma tumors in the absence of the NK-activating receptor NKp46/NCR1. J Immunol 182(4): 2221-2230.
  34. Cagnano, E., Hershkovitz, O., Zilka, A., Bar-Ilan, A., Golder, A., Sion-Vardy, N., Bogdanov-Berezovsky, A., Mandelboim, O., Benharroch, D. and Porgador, A. (2008). Expression of ligands to NKp46 in benign and malignant melanocytes. J Invest Dermatol 128(4): 972-979.
  35. Ho, J. W., Hershkovitz, O., Peiris, M., Zilka, A., Bar-Ilan, A., Nal, B., Chu, K., Kudelko, M., Kam, Y. W., Achdout, H., Mandelboim, M., Altmeyer, R., Mandelboim, O., Bruzzone, R. and Porgador, A. (2008). H5-type influenza virus hemagglutinin is functionally recognized by the natural killer-activating receptor NKp44. J Virol 82(4): 2028-2032.
  36. Gazit, R., Hershko, K., Ingbar, A., Schlesinger, M., Israel, S., Brautbar, C., Mandelboim, O. and Leibovici, V. (2008). Immunological assessment of familial tinea corporis. J Eur Acad Dermatol Venereol 22(7): 871-874.
  37. Arnon, T. I., Markel, G., Bar-Ilan, A., Hanna, J., Fima, E., Benchetrit, F., Galili, R., Cerwenka, A., Benharroch, D., Sion-Vardy, N., Porgador, A. and Mandelboim, O. (2008). Harnessing soluble NK cell killer receptors for the generation of novel cancer immune therapy. PLoS ONE 3(5): e2150.
  38. Achdout, H., Manaster, I. and Mandelboim, O. (2008). Influenza virus infection augments NK cell inhibition through reorganization of major histocompatibility complex class I proteins. J Virol 82(16): 8030-8037.
  39. Manaster, I., Mizrahi, S., Goldman-Wohl, D., Sela, H. Y., Stern-Ginossar, N., Lankry, D., Gruda, R., Hurwitz, A., Bdolah, Y., Haimov-Kochman, R., Yagel, S. and Mandelboim, O. (2008). Endometrial NK cells are special immature cells that await pregnancy. J Immunol 181(3): 1869-1876.
  40. Stern-Ginossar, N., Gur, C., Biton, M., Horwitz, E., Elboim, M., Stanietsky, N., Mandelboim, M. and Mandelboim, O. (2008). Human microRNAs regulate stress-induced immune responses mediated by the receptor NKG2D. Nat Immunol 9(9): 1065-1073.
  41. Satoh-Takayama, N., Vosshenrich, C. A., Lesjean-Pottier, S., Sawa, S., Lochner, M., Rattis, F., Mention, J. J., Thiam, K., Cerf-Bensussan, N., Mandelboim, O., Eberl, G. and Di Santo, J. P. (2008). Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense. Immunity 29(6): 958-970.
  42. Hershkovitz, O., Jarahian, M., Zilka, A., Bar-Ilan, A., Landau, G., Jivov, S., Tekoah, Y., Glicklis, R., Gallagher, J. T., Hoffmann, S. C., Zer, H., Mandelboim, O., Watzl, C., Momburg, F. and Porgador, A. (2008). Altered glycosylation of recombinant NKp30 hampers binding to heparan sulfate: a lesson for the use of recombinant immunoreceptors as an immunological tool. Glycobiology 18(1): 28-41.
  43. Manaster, I. and Mandelboim, O. (2008). The unique properties of human NK cells in the uterine mucosa. Placenta 29 Suppl A: S60-66.
  44. Mizrahi, S., Yefenof, E., Gross, M., Attal, P., Ben Yaakov, A., Goldman-Wohl, D., Maly, B., Stern, N., Katz, G., Gazit, R., Sionov, R. V., Mandelboim, O. and Chaushu, S. (2007). A phenotypic and functional characterization of NK cells in adenoids. J Leukoc Biol 82(5): 1095-1105.
  45. Lee, H. S., Boulton, I. C., Reddin, K., Wong, H., Halliwell, D., Mandelboim, O., Gorringe, A. R. and Gray-Owen, S. D. (2007). Neisserial outer membrane vesicles bind the coinhibitory receptor carcinoembryonic antigen-related cellular adhesion molecule 1 and suppress CD4+ T lymphocyte function. Infect Immun 75(9): 4449-4455.
  46. Hanna, J. and Mandelboim, O. (2007). When killers become helpers. Trends Immunol 28(5): 201-206.
  47. Nachmias, B., Lazar, I., Elmalech, M., Abed-El-Rahaman, I., Asshab, Y., Mandelboim, O., Perlman, R. and Ben-Yehuda, D. (2007). Subcellular localization determines the delicate balance between the anti- and pro-apoptotic activity of Livin. Apoptosis 12(7): 1129-1142.
  48. Gonen-Gross, T. and Mandelboim, O. (2007). HLA-G complexes are observed on the cell surface. Hum Immunol 68(4): 227-232.
  49. Stern-Ginossar, N., Elefant, N., Zimmermann, A., Wolf, D. G., Saleh, N., Biton, M., Horwitz, E., Prokocimer, Z., Prichard, M., Hahn, G., Goldman-Wohl, D., Greenfield, C., Yagel, S., Hengel, H., Altuvia, Y., Margalit, H. and Mandelboim, O. (2007). Host immune system gene targeting by a viral miRNA. Science 317(5836): 376-381.
  50. Gruda, R., Achdout, H., Stern-Ginossar, N., Gazit, R., Betser-Cohen, G., Manaster, I., Katz, G., Gonen-Gross, T., Tirosh, B. and Mandelboim, O. (2007). Intracellular cysteine residues in the tail of MHC class I proteins are crucial for extracellular recognition by leukocyte Ig-like receptor 1. J Immunol 179(6): 3655-3661.
  51. Stern-Ginossar, N., Nedvetzki, S., Markel, G., Gazit, R., Betser-Cohen, G., Achdout, H., Aker, M., Blumberg, R. S., Davis, D. M., Appelmelk, B. and Mandelboim, O. (2007). Intercellular transfer of carcinoembryonic antigen from tumor cells to NK cells. J Immunol 179(7): 4424-4434.
  52. Mizrahi, S., Markel, G., Porgador, A., Bushkin, Y. and Mandelboim, O. (2007). CD100 on NK cells enhance IFNgamma secretion and killing of target cells expressing CD72. PLoS ONE 2(9): e818.
  53. Nachmias, B., Mizrahi, S., Elmalech, M., Lazar, I., Ashhab, Y., Gazit, R., Markel, G., Ben-Yehuda, D. and Mandelboim, O. (2007). Manipulation of NK cytotoxicity by the IAP family member Livin. Eur J Immunol 37(12): 3467-3476.
  54. Yutkin, V., Pode, D., Pikarsky, E. and Mandelboim, O. (2007). The expression level of ligands for natural killer cell receptors predicts response to bacillus Calmette-Guerin therapy: a pilot study. J Urol 178(6): 2660-2664.
  55. Vosshenrich, C. A., Lesjean-Pottier, S., Hasan, M., Richard-Le Goff, O., Corcuff, E., Mandelboim, O. and Di Santo, J. P. (2007). CD11cloB220+ interferon-producing killer dendritic cells are activated natural killer cells. J Exp Med 204(11): 2569-2578.
  56. Gazit, R., Aker, M., Elboim, M., Achdout, H., Katz, G., Wolf, D. G., Katzav, S. and Mandelboim, O. (2007). NK cytotoxicity mediated by CD16 but not by NKp30 is functional in Griscelli syndrome. Blood 109(10): 4306-4312.
  57. Arnon, T. I., Markel, G. and Mandelboim, O. (2006). Tumor and viral recognition by natural killer cells receptors. Semin Cancer Biol 16(5): 348-358.
  58. Betser-Cohen, G., Katz, G., Gonen-Gross, T., Stern, N., Arnon, T. I., Achdout, H., Gazit, R. and Mandelboim, O. (2006). Reduced KIR2DL1 recognition of MHC class I molecules presenting phosphorylated peptides. J Immunol 176(11): 6762-6769.
  59. Drukker, M., Katchman, H., Katz, G., Even-Tov Friedman, S., Shezen, E., Hornstein, E., Mandelboim, O., Reisner, Y. and Benvenisty, N. (2006). Human embryonic stem cells and their differentiated derivatives are less susceptible to immune rejection than adult cells. Stem Cells 24(2): 221-229.
  60. Gazit, R., Gruda, R., Elboim, M., Arnon, T. I., Katz, G., Achdout, H., Hanna, J., Qimron, U., Landau, G., Greenbaum, E., Zakay-Rones, Z., Porgador, A. and Mandelboim, O. (2006). Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1. Nat Immunol 7(5): 517-523.
  61. Yu, Q., Chow, E. M., Wong, H., Gu, J., Mandelboim, O., Gray-Owen, S. D. and Ostrowski, M. A. (2006). CEACAM1 (CD66a) promotes human monocyte survival via a phosphatidylinositol 3-kinase- and AKT-dependent pathway. J Biol Chem 281(51): 39179-39193.
  62. Markel, G., Seidman, R., Stern, N., Cohen-Sinai, T., Izhaki, O., Katz, G., Besser, M., Treves, A. J., Blumberg, R. S., Loewenthal, R., Mandelboim, O., Orenstein, A. and Schachter, J. (2006). Inhibition of human tumor-infiltrating lymphocyte effector functions by the homophilic carcinoembryonic cell adhesion molecule 1 interactions. J Immunol 177(9): 6062-6071.
  63. Hanna, J., Goldman-Wohl, D., Hamani, Y., Avraham, I., Greenfield, C., Natanson-Yaron, S., Prus, D., Cohen-Daniel, L., Arnon, T. I., Manaster, I., Gazit, R., Yutkin, V., Benharroch, D., Porgador, A., Keshet, E., Yagel, S. and Mandelboim, O. (2006). Decidual NK cells regulate key developmental processes at the human fetal-maternal interface. Nat Med 12(9): 1065-1074.
  64. Munitz, A., Bachelet, I., Fraenkel, S., Katz, G., Mandelboim, O., Simon, H. U., Moretta, L., Colonna, M. and Levi-Schaffer, F. (2005). 2B4 (CD244) is expressed and functional on human eosinophils. J Immunol 174(1): 110-118.
  65. Arnon, T. I., Achdout, H., Levi, O., Markel, G., Saleh, N., Katz, G., Gazit, R., Gonen-Gross, T., Hanna, J., Nahari, E., Porgador, A., Honigman, A., Plachter, B., Mevorach, D., Wolf, D. G. and Mandelboim, O. (2005). Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus. Nat Immunol 6(5): 515-523.
  66. Stern, N., Markel, G., Arnon, T. I., Gruda, R., Wong, H., Gray-Owen, S. D. and Mandelboim, O. (2005). Carcinoembryonic antigen (CEA) inhibits NK killing via interaction with CEA-related cell adhesion molecule 1. J Immunol 174(11): 6692-6701.
  67. Azuz-Lieberman, N., Markel, G., Mizrahi, S., Gazit, R., Hanna, J., Achdout, H., Gruda, R., Katz, G., Arnon, T. I., Battat, S., Zamir, E., Adawi, M., Mader, R. and Mandelboim, O. (2005). The involvement of NK cells in ankylosing spondylitis. Int Immunol 17(7): 837-845.
  68. Gonen-Gross, T., Achdout, H., Arnon, T. I., Gazit, R., Stern, N., Horejsi, V., Goldman-Wohl, D., Yagel, S. and Mandelboim, O. (2005). The CD85J/leukocyte inhibitory receptor-1 distinguishes between conformed and beta 2-microglobulin-free HLA-G molecules. J Immunol 175(8): 4866-4874.
  69. Hanna, J., Mussaffi, H., Steuer, G., Hanna, S., Deeb, M., Blau, H., Arnon, T. I., Weizman, N. and Mandelboim, O. (2005). Functional aberrant expression of CCR2 receptor on chronically activated NK cells in patients with TAP-2 deficiency. Blood 106(10): 3465-3473.
  70. Hanna, J., Fitchett, J., Rowe, T., Daniels, M., Heller, M., Gonen-Gross, T., Manaster, E., Cho, S. Y., LaBarre, M. J. and Mandelboim, O. (2005). Proteomic analysis of human natural killer cells: insights on new potential NK immune functions. Mol Immunol 42(4): 425-431.