Ana Martin-Villalba
  • Molecular Neurobiology, German Cancer Research Center (DKFZ), Germany
  • Neuroscience


Master of Management, Helmholtz academy, Malik zentrum St. Gallen (MZSG), 2011

Venia legendi (Habilitation), University of Heidelberg, Germany, 2007

Ph.D., (homologation) Spanish Ministry of Education and Culture, ES, 2000

M.D., University of Heidelberg, Germany, 1998

Medical approbation, University of Murcia, Spain, 1995

Current position

Professor and Division Head, Molecular Neurobiology, German Cancer Research Center, Heidelberg, Germany

Publications (since 2005)

  1. Martin-Villalba, A., Llorens-Bobadilla, E. and Wollny, D. (2013). CD95 in cancer: tool or target? Trends Mol Med 19(6): 329-335.
  2. Seib, D. R., Corsini, N. S., Ellwanger, K., Plaas, C., Mateos, A., Pitzer, C., Niehrs, C., Celikel, T. and Martin-Villalba, A. (2013). Loss of Dickkopf-1 restores neurogenesis in old age and counteracts cognitive decline. Cell Stem Cell 12(2): 204-214.
  3. Milde, T., Kleber, S., Korshunov, A., Witt, H., Hielscher, T., Koch, P., Kopp, H. G., Jugold, M., Deubzer, H. E., Oehme, I., Lodrini, M., Grone, H. J., Benner, A., Brustle, O., Gilbertson, R. J., von Deimling, A., Kulozik, A. E., Pfister, S. M., Martin-Villalba, A. and Witt, O. (2011). A novel human high-risk ependymoma stem cell model reveals the differentiation-inducing potential of the histone deacetylase inhibitor Vorinostat. Acta Neuropathol 122(5): 637-650.
  4. Zhang, M., Kleber, S., Rohrich, M., Timke, C., Han, N., Tuettenberg, J., Martin-Villalba, A., Debus, J., Peschke, P., Wirkner, U., Lahn, M. and Huber, P. E. (2011). Blockade of TGF-beta signaling by the TGFbetaR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma. Cancer Res 71(23): 7155-7167.
  5. Ribeiro, D., Ellwanger, K., Glagow, D., Theofilopoulos, S., Corsini, N. S., Martin-Villalba, A., Niehrs, C. and Arenas, E. (2011). Dkk1 regulates ventral midbrain dopaminergic differentiation and morphogenesis. PLoS One 6(2): e15786.
  6. Corsini, N. S. and Martin-Villalba, A. (2010). Integrin alpha 6: anchors away for glioma stem cells. Cell Stem Cell 6(5): 403-404.
  7. Pitzer, C., Klussmann, S., Kruger, C., Letellier, E., Plaas, C., Dittgen, T., Kirsch, F., Stieltjes, B., Weber, D., Laage, R., Martin-Villalba, A. and Schneider, A. (2010). The hematopoietic factor granulocyte-colony stimulating factor improves outcome in experimental spinal cord injury. J Neurochem 113(4): 930-942.
  8. Letellier, E., Kumar, S., Sancho-Martinez, I., Krauth, S., Funke-Kaiser, A., Laudenklos, S., Konecki, K., Klussmann, S., Corsini, N. S., Kleber, S., Drost, N., Neumann, A., Levi-Strauss, M., Brors, B., Gretz, N., Edler, L., Fischer, C., Hill, O., Thiemann, M., Biglari, B., Karray, S. and Martin-Villalba, A. (2010). CD95-ligand on peripheral myeloid cells activates Syk kinase to trigger their recruitment to the inflammatory site. Immunity 32(2): 240-252.
  9. Teodorczyk, M. and Martin-Villalba, A. (2010). Sensing invasion: cell surface receptors driving spreading of glioblastoma. J Cell Physiol 222(1): 1-10.
  10. Corsini, N. S., Sancho-Martinez, I., Laudenklos, S., Glagow, D., Kumar, S., Letellier, E., Koch, P., Teodorczyk, M., Kleber, S., Klussmann, S., Wiestler, B., Brustle, O., Mueller, W., Gieffers, C., Hill, O., Thiemann, M., Seedorf, M., Gretz, N., Sprengel, R., Celikel, T. and Martin-Villalba, A. (2009). The death receptor CD95 activates adult neural stem cells for working memory formation and brain repair. Cell Stem Cell 5(2): 178-190.
  11. Mora, R., Abschuetz, A., Kees, T., Dokic, I., Joschko, N., Kleber, S., Geibig, R., Mosconi, E., Zentgraf, H., Martin-Villalba, A. and Regnier-Vigouroux, A. (2009). TNF-alpha- and TRAIL-resistant glioma cells undergo autophagy-dependent cell death induced by activated microglia. Glia 57(5): 561-581.
  12. Sancho-Martinez, I. and Martin-Villalba, A. (2009). Tyrosine phosphorylation and CD95: a FAScinating switch. Cell Cycle 8(6): 838-842.
  13. Martin-Villalba, A., Okuducu, A. F. and von Deimling, A. (2008). The evolution of our understanding on glioma. Brain Pathol 18(3): 455-463.
  14. Kleber, S., Sancho-Martinez, I., Wiestler, B., Beisel, A., Gieffers, C., Hill, O., Thiemann, M., Mueller, W., Sykora, J., Kuhn, A., Schreglmann, N., Letellier, E., Zuliani, C., Klussmann, S., Teodorczyk, M., Grone, H. J., Ganten, T. M., Sultmann, H., Tuttenberg, J., von Deimling, A., Regnier-Vigouroux, A., Herold-Mende, C. and Martin-Villalba, A. (2008). Yes and PI3K bind CD95 to signal invasion of glioblastoma. Cancer Cell 13(3): 235-248.
  15. Letellier, E. and Martin-Villalba, A. (2007). Spinal cord injuries entering the Fas(t) lane. Neurosurgery 60(6): N6-7.
  16. Kuhn, A., Herrmann, M., Kleber, S., Beckmann-Welle, M., Fehsel, K., Martin-Villalba, A., Lehmann, P., Ruzicka, T., Krammer, P. H. and Kolb-Bachofen, V. (2006). Accumulation of apoptotic cells in the epidermis of patients with cutaneous lupus erythematosus after ultraviolet irradiation. Arthritis Rheum 54(3): 939-950.
  17. Stieltjes, B., Klussmann, S., Bock, M., Umathum, R., Mangalathu, J., Letellier, E., Rittgen, W., Edler, L., Krammer, P. H., Kauczor, H. U., Martin-Villalba, A. and Essig, M. (2006). Manganese-enhanced magnetic resonance imaging for in vivo assessment of damage and functional improvement following spinal cord injury in mice. Magn Reson Med 55(5): 1124-1131.
  18. Zuliani, C., Kleber, S., Klussmann, S., Wenger, T., Kenzelmann, M., Schreglmann, N., Martinez, A., del Rio, J. A., Soriano, E., Vodrazka, P., Kuner, R., Groene, H. J., Herr, I., Krammer, P. H. and Martin-Villalba, A. (2006). Control of neuronal branching by the death receptor CD95 (Fas/Apo-1). Cell Death Differ 13(1): 31-40.
  19. Klussmann, S. and Martin-Villalba, A. (2005). Molecular targets in spinal cord injury. J Mol Med (Berl) 83(9): 657-671.
  20. Jennemann, R., Sandhoff, R., Wang, S., Kiss, E., Gretz, N., Zuliani, C., Martin-Villalba, A., Jager, R., Schorle, H., Kenzelmann, M., Bonrouhi, M., Wiegandt, H. and Grone, H. J. (2005). Cell-specific deletion of glucosylceramide synthase in brain leads to severe neural defects after birth. Proc Natl Acad Sci U S A 102(35): 12459-12464.
  21. Bernhard, M., Gries, A., Kremer, P., Martin-Villalba, A. and Bottiger, B. W. (2005). [Prehospital management of spinal cord injuries]. Anaesthesist 54(4): 357-376.