Didier Trouche
  • LBCMCP CNRS UMR5088, University of Toulouse UPS, France
  • Cancer biology


Ph.D. in Biology, Ecole Centrale de Paris, France, 1993

Current position

Principal Investigator (CNRS), Laboratory of Molecular and Cell Biology of Proliferation Control, UMR 5088, P. Sabatier University, Toulouse, France

Publications (since 2005)

  1. Courilleau, C., Chailleux, C., Jauneau, A., Grimal, F., Briois, S., Boutet-Robinet, E., Boudsocq, F., Trouche, D.* and Canitrot, Y.* (2012). The chromatin remodeler p400 ATPase facilitates Rad51-mediated repair of DNA double-strand breaks. J Cell Biol 199(7): 1067-1081. (*co last-author)
  2. Verrier, L., Vandromme, M. and Trouche, D. (2011). Histone demethylases in chromatin cross-talks. Biol Cell 103(8): 381-401.
  3. Verrier, L., Escaffit, F., Chailleux, C., Trouche, D.* and Vandromme, M.* (2011). A new isoform of the histone demethylase JMJD2A/KDM4A is required for skeletal muscle differentiation. PLoS Genet 7(6): e1001390. (*co last-author)
  4. Capp, J. P., Boudsocq, F., Bergoglio, V., Trouche, D., Cazaux, C., Blanco, L., Hoffmann, J. S. and Canitrot, Y. (2010). The R438W polymorphism of human DNA polymerase lambda triggers cellular sensitivity to camptothecin by compromising the homologous recombination repair pathway. Carcinogenesis 31(10): 1742-1747.
  5. Massip, L., Caron, P., Iacovoni, J. S., Trouche, D. and Legube, G. (2010). Deciphering the chromatin landscape induced around DNA double strand breaks. Cell Cycle 9(15): 2963-2972.
  6. Mattera, L.*, Courilleau, C.*,Legube, G., Ueda, T., Fukunaga, R., Chevillard-Briet, M., Canitrot, Y.§, Escaffit, F.§ and Trouche, D. (2010). The E1A-associated p400 protein modulates cell fate decisions by the regulation of ROS homeostasis. PLoS Genet 6(6): e1000983. (*co-first authors; § equal contribution)
  7. Iacovoni, J.S.*, Caron, P.*, Nicolas, E., Massip, L., Trouche, D.§ and Legube, G.§ (2010). High-resolution profiling of gammaH2AX around DNA double strand breaks in the mammalian genome. EMBO J 29(8): 1446-1457. (*co-first authors; § equal contribution)
  8. Chailleux, C.*, Tyteca, S.*, Papin, C., Boudsocq, F., Puget, N., Courilleau, C., Grigoriev, M., Canitrot, Y. and Trouche, D. (2010). Physical interaction between the histone acetyl transferase Tip60 and the DNA double-strand breaks sensor MRN complex. Biochem J 426(3): 365-371. (*co last-author)
  9. Pillaire, M. J., Selves, J., Gordien, K., Gourraud, P. A., Gentil, C., Danjoux, M., Do, C., Negre, V., Bieth, A., Guimbaud, R., Trouche, D., Pasero, P., Mechali, M., Hoffmann, J. S. and Cazaux, C. (2010). A 'DNA replication' signature of progression and negative outcome in colorectal cancer. Oncogene 29(6): 876-887.
  10. Mattera, L.*, Escaffit, F.*, Pillaire, M. J., Selves, J., Tyteca, S., Hoffmann, J. S., Gourraud, P. A., Chevillard-Briet, M.§, Cazaux, C.§ and Trouche, D. (2009). The p400/Tip60 ratio is critical for colorectal cancer cell proliferation through DNA damage response pathways. Oncogene 28(12): 1506-1517.
  11. Fauquier, L., Duboe, C., Jore, C., Trouche, D. and Vandel, L. (2008). Dual role of the arginine methyltransferase CARM1 in the regulation of c-Fos target genes. FASEB J 22(9): 3337-3347.
  12. Vandromme, M. *, Chailleux, C. *, Escaffit, F. and Trouche, D. (2008). Binding of the retinoblastoma protein is not the determinant for stable repression of some E2F-regulated promoters in muscle cells. Mol Cancer Res 6(3): 418-425. (*co-first authors)
  13. Escaffit, F., Vaute, O., Chevillard-Briet, M., Segui, B., Takami, Y., Nakayama, T. and Trouche, D. (2007). Cleavage and cytoplasmic relocalization of histone deacetylase 3 are important for apoptosis progression. Mol Cell Biol 27(2): 554-567.
  14. Tyteca, S., Legube, G. and Trouche, D. (2006). To die or not to die: a HAT trick. Mol Cell 24(6): 807-808.
  15. Tyteca, S., Vandromme, M., Legube, G., Chevillard-Briet, M. and Trouche, D. (2006). Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression. EMBO J 25(8): 1680-1689. Selected by EMBO J editors as one of the four best papers published by EMBO J during the first half of 2006 (EMBOencounters 6, summer 2006)
  16. Daury, L.*, Chailleux, C.*, Bonvallet, J. and Trouche, D. (2006). Histone H3.3 deposition at E2F-regulated genes is linked to transcription. EMBO Rep 7(1): 66-71. (*co-first authors)
  17. Col, E., Caron, C., Chable-Bessia, C., Legube, G., Gazzeri, S., Komatsu, Y., Yoshida, M., Benkirane, M., Trouche, D. and Khochbin, S. (2005). HIV-1 Tat targets Tip60 to impair the apoptotic cell response to genotoxic stresses. EMBO J 24(14): 2634-2645.
  18. Nicolas, E., Daury, L., Trouche, D. (2005). Regulation of E2F-responsive genes through histone modifications. In Rb and Tumoriginesis, M Fanciulli (Ed), Landes Biosciences.(http://www.eurekah.com/abstract.php?chapid=2359&bookid=171&catid=31).
  19. Regnier, V.*, Vagnarelli, P., Fukagawa, T., Zerjal, T., Burns, E., Trouche, D., Earnshaw, W. and Brown, W. (2005). CENP-A is required for accurate chromosome segregation and sustained kinetochore association of BubR1. Mol Cell Biol 25(10): 3967-3981. (*corresponding author)