Education

Ph.D., Laboratory of Physiology CNRS UMR 8572-USM 501 Evolution des régulations endocriniennes Museum National d'Histoire Naturelle, Paris, France, 2004

Current Position

Post-Doc fellow, Molecular Basis of Polycystic Kidney Disease Unit Director: Alessandra Boletta, Division of Genetics and Cell Biology, Dibit - San Raffaele, Via Olgettina 58, Milan, Italy (from July 2004 to date)

Publications

1. Castelli, M., Boca, M., Chiaravalli, M., Ramalingam, H., Rowe, I., Distefano, G., Carroll, T. and Boletta, A. (2013). Polycystin-1 binds Par3/aPKC and controls convergent extension during renal tubular morphogenesis. Nat Commun 4: 2658.
   
2. Rowe, I., Chiaravalli, M., Mannella, V., Ulisse, V., Quilici, G., Pema, M., Song, X. W., Xu, H., Mari, S., Qian, F., Pei, Y., Musco, G. and Boletta, A. (2013). Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy. Nat Med 19(4): 488-493.
   
3. Wodarczyk, C., Distefano, G., Rowe, I., Gaetani, M., Bricoli, B., Muorah, M., Spitaleri, A., Mannella, V., Ricchiuto, P., Pema, M., Castelli, M., Casanova, A. E., Mollica, L., Banzi, M., Boca, M., Antignac, C., Saunier, S., Musco, G. and Boletta, A. (2010). Nephrocystin-1 forms a complex with polycystin-1 via a polyproline motif/SH3 domain interaction and regulates the apoptotic response in mammals. PLoS One 5(9): e12719.
   
4. Wodarczyk, C.*, Rowe, I.*, Chiaravalli, M., Pema, M., Qian, F. and Boletta, A. (2009). A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus. PLoS One 4(9): e7137. *equal contribution
   
5. Distefano, G., Boca, M., Rowe, I., Wodarczyk, C., Ma, L., Piontek, K. B., Germino, G. G., Pandolfi, P. P. and Boletta, A. (2009). Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1. Mol Cell Biol 29(9): 2359-2371.
   
6. Coen, L., Le Blay, K., Rowe, I. and Demeneix, B. A. (2007). Caspase-9 regulates apoptosis/proliferation balance during metamorphic brain remodeling in Xenopus. Proc Natl Acad Sci U S A 104(20): 8502-8507.
   
7. Rowe, I., Le Blay, K., Du Pasquier, D., Palmier, K., Levi, G., Demeneix, B. and Coen, L. (2005). Apoptosis of tail muscle during amphibian metamorphosis involves a caspase 9-dependent mechanism. Dev Dyn 233(1): 76-87.
   
8. Rowe, I., Coen, L., Le Blay, K., Le Mevel, S. and Demeneix, B. A. (2002). Autonomous regulation of muscle fibre fate during metamorphosis in Xenopus tropicalis. Dev Dyn 224(4): 381-390.