Ana Villegas-Mendez
  • Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK
  • Immunology


Ph.D. in Biochemistry, Imperial College London, UK

Current position

Faculty of Life Sciences, University of Manchester, Manchester, UK


  1. Villegas-Mendez, A., de Souza, J. B., Lavelle, S. W., Gwyer Findlay, E., Shaw, T. N., van Rooijen, N., Saris, C. J., Hunter, C. A., Riley, E. M. and Couper, K. N. (2013). IL-27 receptor signalling restricts the formation of pathogenic, terminally differentiated Th1 cells during malaria infection by repressing IL-12 dependent signals. PLoS Pathog 9(4): e1003293.
  2. Gwyer Findlay, E., Villegas-Mendez, A., de Souza, J. B., Inkson, C. A., Shaw, T. N., Saris, C. J., Hunter, C. A., Riley, E. M. and Couper, K. N. (2013). IL-27 receptor signaling regulates CD4+ T cell chemotactic responses during infection. J Immunol 190(9): 4553-4561.
  3. Villegas-Mendez, A., Fender, P., Garin, M. I., Rothe, R., Liguori, L., Marques, B. and Lenormand, J. L. (2012). Functional characterisation of the WW minimal domain for delivering therapeutic proteins by adenovirus dodecahedron. PLoS One 7(9): e45416.
  4. Villegas-Mendez, A., Greig, R., Shaw, T. N., de Souza, J. B., Gwyer Findlay, E., Stumhofer, J. S., Hafalla, J. C., Blount, D. G., Hunter, C. A., Riley, E. M. and Couper, K. N. (2012). IFN-gamma-producing CD4+ T cells promote experimental cerebral malaria by modulating CD8+ T cell accumulation within the brain. J Immunol 189(2): 968-979.
  5. Villegas-Mendez, A., de Souza, J. B., Murungi, L., Hafalla, J. C., Shaw, T. N., Greig, R., Riley, E. M. and Couper, K. N. (2011). Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection. J Immunol 187(6): 2885-2897.
  6. Rothe, R., Liguori, L., Villegas-Mendez, A., Marques, B., Grunwald, D., Drouet, E. and Lenormand, J. L. (2010). Characterization of the cell-penetrating properties of the Epstein-Barr virus ZEBRA trans-activator. J Biol Chem 285(26): 20224-20233.
  7. Villegas-Mendez, A., Garin, M. I., Pineda-Molina, E., Veratti, E., Bueren, J. A., Fender, P. and Lenormand, J. L. (2010). In vivo delivery of antigens by adenovirus dodecahedron induces cellular and humoral immune responses to elicit antitumor immunity. Mol Ther 18(5): 1046-1053.
  8. Liguori, L., Marques, B., Villegas-Mendez, A., Rothe, R. and Lenormand, J.-L. (2008). Liposomes-mediated delivery of pro-apoptotic therapeutic membrane proteins. Journal of Controlled Release 126(3): 217-227.
  9. Marques, B., Liguori, L., Paclet, M. H., Villegas-Mendez, A., Rothe, R., Morel, F. and Lenormand, J. L. (2007). Liposome-mediated cellular delivery of active gp91(phox). PLoS One 2(9): e856.
  10. Villegas-Mendez, A., Montes, R., Ambrose, L. R., Warrens, A. N., Laffan, M. and Lane, D. A. (2007). Proteolysis of the endothelial cell protein C receptor by neutrophil proteinase 3. J Thromb Haemost 5(5): 980-988.
  11. Preston, R. J., Villegas-Mendez, A., Sun, Y. H., Hermida, J., Simioni, P., Philippou, H., Dahlback, B. and Lane, D. A. (2005). Selective modulation of protein C affinity for EPCR and phospholipids by Gla domain mutation. FEBS J 272(1): 97-108.