Luca Quagliata
  • University Hospital Basel
  • Molecular biology


Ph.D. in Vascular Medicine Magna cum Laude, Faculties for Natural Sciences and for Mathematics, Ruperto-Carola University of Heidelberg, Germany, 2011

Current position

NGS Unit Responsible,Institute of Pathology, University Hospital Basel (since 04/2014)


  1. Hansen, M. T., Forst, B., Cremers, N., Quagliata, L., Ambartsumian, N., Grum-Schwensen, B., Klingelhofer, J., Abdul-Al, A., Herrmann, P., Osterland, M., Stein, U., Nielsen, G. H., Scherer, P. E., Lukanidin, E., Sleeman, J. P. and Grigorian, M. (2015). A link between inflammation and metastasis: serum amyloid A1 and A3 induce metastasis, and are targets of metastasis-inducing S100A4. Oncogene 34(4): 424-435.
  2. Rothweiler, S., Dill, M. T., Terracciano, L., Makowska, Z., Quagliata, L., Hlushchuk, R., Djonov, V., Heim, M. H. and Semela, D. (2015). Generation of a murine hepatic angiosarcoma cell line and reproducible mouse tumor model. Lab Invest 95(3): 351-362.
  3. Zavattari, P., Perra, A., Menegon, S., Kowalik, M. A., Petrelli, A., Angioni, M. M., Follenzi, A., Quagliata, L., Ledda-Columbano, G. M., Terracciano, L., Giordano, S. and Columbano, A. (2015). Nrf2, but not beta-catenin, mutation represents an early event in rat hepatocarcinogenesis. Hepatology.
  4. Andreozzi, M., Quagliata, L., Gsponer, J. R., Ruiz, C., Vuaroqueaux, V., Eppenberger-Castori, S., Tornillo, L. and Terracciano, L. M. (2014). VEGFA gene locus analysis across 80 human tumour types reveals gene amplification in several neoplastic entities. Angiogenesis 17(3): 519-527.
  5. Crea, F., Watahiki, A., Quagliata, L., Xue, H., Pikor, L., Parolia, A., Wang, Y., Lin, D., Lam, W. L., Farrar, W. L., Isogai, T., Morant, R., Castori-Eppenberger, S., Chi, K. N., Wang, Y. and Helgason, C. D. (2014). Identification of a long non-coding RNA as a novel biomarker and potential therapeutic target for metastatic prostate cancer. Oncotarget 5(3): 764-774. 
  6. Quagliata, L., Andreozzi, M., Kovac, M., Tornillo, L., Makowska, Z., Moretti, F., Heim, M. H., Heinimann, K., Piscuoglio, S. and Terracciano, L. M. (2014). SH2D4A is frequently downregulated in hepatocellular carcinoma and cirrhotic nodules. Eur J Cancer 50(4): 731-738.
  7. Quagliata, L., Klusmeier, S., Cremers, N., Pytowski, B., Harvey, A., Pettis, R. J., Thiele, W. and Sleeman, J. P. (2014). Inhibition of VEGFR-3 activation in tumor-draining lymph nodes suppresses the outgrowth of lymph node metastases in the MT-450 syngeneic rat breast cancer model. Clin Exp Metastasis 31(3): 351-365. 
  8. Horwitz, E., Stein, I., Andreozzi, M., Nemeth, J., Shoham, A., Pappo, O., Schweitzer, N., Tornillo, L., Kanarek, N., Quagliata, L., Zreik, F., Porat, R. M., Finkelstein, R., Reuter, H., Koschny, R., Ganten, T., Mogler, C., Shibolet, O., Hess, J., Breuhahn, K., Grunewald, M., Schirmacher, P., Vogel, A., Terracciano, L., Angel, P., Ben-Neriah, Y. and Pikarsky, E. (2014). Human and mouse VEGFA-amplified hepatocellular carcinomas are highly sensitive to sorafenib treatment. Cancer Discov 4(6): 730-743.
  9. Arabi, L., Gsponer, J. R., Smida, J., Nathrath, M., Perrina, V., Jundt, G., Ruiz, C., Quagliata, L. and Baumhoer, D. (2014). Upregulation of the miR-17-92 cluster and its two paraloga in osteosarcoma - reasons and consequences. Genes Cancer 5(1-2): 56-63.
  10. Lepore, M., Kalinichenko, A., Colone, A., Paleja, B., Singhal, A., Tschumi, A., Lee, B., Poidinger, M., Zolezzi, F., Quagliata, L., Sander, P., Newell, E., Bertoletti, A., Terracciano, L., De Libero, G. and Mori, L. (2014). Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRbeta repertoire. Nat Commun 5: 3866.
  11. Cornu, M., Oppliger, W., Albert, V., Robitaille, A. M., Trapani, F., Quagliata, L., Fuhrer, T., Sauer, U., Terracciano, L. and Hall, M. N. (2014). Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21. Proc Natl Acad Sci U S A 111(32): 11592-11599.
  12. Quagliata, L. and Terracciano, L. M. (2014). Liver Diseases and Long Non-Coding RNAs: New Insight and Perspective. Front Med (Lausanne) 1: 35.
  13. Hefetz-Sela, S., Stein, I., Klieger, Y., Porat, R., Sade-Feldman, M., Zreik, F., Nagler, A., Pappo, O., Quagliata, L., Dazert, E., Eferl, R., Terracciano, L., Wagner, E. F., Ben-Neriah, Y., Baniyash, M. and Pikarsky, E. (2014). Acquisition of an immunosuppressive protumorigenic macrophage phenotype depending on c-Jun phosphorylation. Proc Natl Acad Sci U S A 111(49): 17582-17587.
  14. Quagliata, L., Matter, M. S., Piscuoglio, S., Arabi, L., Ruiz, C., Procino, A., Kovac, M., Moretti, F., Makowska, Z., Boldanova, T., Andersen, J. B., Hammerle, M., Tornillo, L., Heim, M. H., Diederichs, S., Cillo, C. and Terracciano, L. M. (2014). Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients. Hepatology 59(3): 911-923.
  15. Quagliata, L., Schlageter, M., Quintavalle, C., Tornillo, L. and Terracciano, L. (2014). Identification of new players in hepatocarcinogenesis: Limits and opportunities of using tissue microarray (TMA). Microarray 3(2): 91-102.
  16. Thiele, W., Rothley, M., Teller, N., Jung, N., Bulat, B., Plaumann, D., Vanderheiden, S., Schmaus, A., Cremers, N., Goppert, B., Dimmler, A., Eschbach, V., Quagliata, L., Thaler, S., Marko, D., Brase, S. and Sleeman, J. P. (2013). Delphinidin is a novel inhibitor of lymphangiogenesis but promotes mammary tumor growth and metastasis formation in syngeneic experimental rats. Carcinogenesis 34(12): 2804-2813.
  17. Thiele, W., Krishnan, J., Rothley, M., Weih, D., Plaumann, D., Kuch, V., Quagliata, L., Weich, H. A. and Sleeman, J. P. (2012). VEGFR-3 is expressed on megakaryocyte precursors in the murine bone marrow and plays a regulatory role in megakaryopoiesis. Blood 120(9): 1899-1907.
  18. Bimonte, S., De Angelis, A., Quagliata, L., Giusti, F., Tammaro, R., Dallai, R., Ascenzi, M. G., Diez-Roux, G. and Franco, B. (2011). Ofd1 is required in limb bud patterning and endochondral bone development. Dev Biol 349(2): 179-191.