Domingo F. Barber
  • Department of Immunology and Oncology, Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Científicas, Spain
  • Cancer biology


Ph.D., Centro de Biología Molecular Severo Ochoa (CBMSO-CSIC), Madrid, 1996

Current position

Tenuered Scientist (Científico Titular)/Group Leader, Departamento de Inmunología y Oncología (DIO), e Iniciativa en NanoBiomedicina, Centro Nacional de Biotecnología (CNB-CSIC), Madrid (2008 – present)

Publications(since 2010)

  1. Rojas, J. M., Sanz-Ortega, L., Mulens-Arias, V., Gutierrez, L., Perez-Yague, S. and Barber, D. F. (2015). Superparamagnetic iron oxide nanoparticle uptake alters M2 macrophage phenotype, iron metabolism, migration and invasion. Nanomedicine.
  2. Mulens-Arias, V., Rojas, J. M., Perez-Yague, S., Morales Mdel, P. and Barber, D. F. (2015). Polyethylenimine-coated SPION exhibits potential intrinsic anti-metastatic properties inhibiting migration and invasion of pancreatic tumor cells. J Control Release 216: 78-92.
  3. Spada, R., Rojas, J. M. and Barber, D. F. (2015). Recent findings on the role of natural killer cells in the pathogenesis of systemic lupus erythematosus. J Leukoc Biol 98(4): 479-487.
  4. ulens-Arias, V., Rojas, J. M., Perez-Yague, S., Morales, M. P. and Barber, D. F. (2015). Polyethylenimine-coated SPIONs trigger macrophage activation through TLR-4 signaling and ROS production and modulate podosome dynamics. Biomaterials 52: 494-506.
  5. Spada, R., Rojas, J. M., Perez-Yague, S., Mulens, V., Cannata-Ortiz, P., Bragado, R. and Barber, D. F. (2015). NKG2D ligand overexpression in lupus nephritis correlates with increased NK cell activity and differentiation in kidneys but not in the periphery. J Leukoc Biol 97(3): 583-598.
  6. Suarez-Fueyo, A., Rojas, J. M., Cariaga, A. E., Garcia, E., Steiner, B. H., Barber, D. F., Puri, K. D. and Carrera, A. C. (2014). Inhibition of PI3Kdelta reduces kidney infiltration by macrophages and ameliorates systemic lupus in the mouse. J Immunol 193(2): 544-554.
  7. “Development of Magnetic Nanoparticles for Cancer Gene Therapy”. Mulens V, Morales MP, Barber DF.ISRN Nanomaterials. 2013 Aug 13; Volume 2013, Article ID 646284.
  8. Zotes, T. M., Spada, R., Mulens, V., Perez-Yague, S., Sorzano, C. O., Okkenhaug, K., Carrera, A. C. and Barber, D. F. (2013). PI3K p110delta is expressed by gp38(-)CD31(+) and gp38(+)CD31(+) spleen stromal cells and regulates their CCL19, CCL21, and LTbetaR mRNA levels. PLoS One 8(8): e72960.
  9. Zotes, T. M., Arias, C. F., Fuster, J. J., Spada, R., Perez-Yague, S., Hirsch, E., Wymann, M., Carrera, A. C., Andres, V. and Barber, D. F. (2013). PI3K p110gamma deletion attenuates murine atherosclerosis by reducing macrophage proliferation but not polarization or apoptosis in lesions. PLoS One 8(8): e72674.
  10. Mejias, R., Gutierrez, L., Salas, G., Perez-Yague, S., Zotes, T. M., Lazaro, F. J., Morales, M. P. and Barber, D. F. (2013). Long term biotransformation and toxicity of dimercaptosuccinic acid-coated magnetic nanoparticles support their use in biomedical applications. J Control Release 171(2): 225-233.
  11. Ruiz, A., Salas, G., Calero, M., Hernandez, Y., Villanueva, A., Herranz, F., Veintemillas-Verdaguer, S., Martinez, E., Barber, D. F.* and Morales, M. P.* (2013). Short-chain PEG molecules strongly bound to magnetic nanoparticle for MRI long circulating agents. Acta Biomater 9(5): 6421-6430. (*Senior authors on this paper)
  12. “Effect of Anesthesia on Magnetic Nanoparticle Biodistribution After Intravenous Injection”. Gutiérrez L, Mejías R, Lázaro FJ, Serna CJ, Barber DF, Morales MP. IEEE Transactions on Magnetics. 2013; 49: 398-401.
  13. Risco, A., del Fresno, C., Mambol, A., Alsina-Beauchamp, D., MacKenzie, K. F., Yang, H. T., Barber, D. F., Morcelle, C., Arthur, J. S., Ley, S. C., Ardavin, C. and Cuenda, A. (2012). p38gamma and p38delta kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation. Proc Natl Acad Sci U S A 109(28): 11200-11205.
  14. Sanchez-Ruiz, J., Mejias, R., Garcia-Belando, M., Barber, D. F. and Gonzalez-Garcia, A. (2011). Ral GTPases regulate cell-mediated cytotoxicity in NK cells. J Immunol 187(5): 2433-2441.
  15. Suarez-Fueyo, A., Barber, D. F., Martinez-Ara, J., Zea-Mendoza, A. C. and Carrera, A. C. (2011). Enhanced phosphoinositide 3-kinase delta activity is a frequent event in systemic lupus erythematosus that confers resistance to activation-induced T cell death. J Immunol 187(5): 2376-2385.
  16. “Ac magnetic susceptibility study of in vivo nanoparticle biodistribution”.Gutierrez L, Mejias R, Barber DF, Veintemillas-Verdaguer S, Serna CJ, Lazaro FJ, and Morales MP. Journal of Physics D-Applied Physics, 2011; 44, Article Number: 255002.
  17. Mejias, R., Perez-Yague, S., Gutierrez, L., Cabrera, L. I., Spada, R., Acedo, P., Serna, C. J., Lazaro, F. J., Villanueva, A., Morales Mdel, P. and Barber, D. F. (2011). Dimercaptosuccinic acid-coated magnetite nanoparticles for magnetically guided in vivo delivery of interferon gamma for cancer immunotherapy. Biomaterials 32(11): 2938-2952.
  18. Mejias, R., Perez-Yague, S., Roca, A. G., Perez, N., Villanueva, A., Canete, M., Manes, S., Ruiz-Cabello, J., Benito, M., Labarta, A., Batlle, X., Veintemillas-Verdaguer, S., Morales, M. P., Barber, D. F. and Serna, C. J. (2010). Liver and brain imaging through dimercaptosuccinic acid-coated iron oxide nanoparticles. Nanomedicine (Lond) 5(3): 397-408.