Education

Ph.D., Immunology, University of California, San Francisco, 1999

Current position

Associate Professor, Dept. of Microbiology & Immunology, Univ. of Michigan Medical School, Ann Arbor, MI

Publications (since 2010)

1. Bronner, D. N., Abuaita, B. H., Chen, X., Fitzgerald, K. A., Nunez, G., He, Y., Yin, X. M. and O'Riordan, M. X. (2015). Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage. Immunity 43(3): 451-462.
2. Abuaita, B. H., Burkholder, K. M., Boles, B. R. and O'Riordan, M. X. (2015). The Endoplasmic Reticulum Stress Sensor Inositol-Requiring Enzyme 1alpha Augments Bacterial Killing through Sustained Oxidant Production. MBio 6(4): e00705.
3. Bronner, D. N. and O'Riordan, M. X. (2014). A near death experience: Shigella manipulates host death machinery to silence innate immunity. EMBO J 33(19): 2137-2139.
4. Charbonneau, M. E., Gonzalez-Hernandez, M. J., Showalter, H. D., Donato, N. J., Wobus, C. E. and O'Riordan, M. X. (2014). Small molecule deubiquitinase inhibitors promote macrophage anti-infective capacity. PLoS One 9(8): e104096.
5. Abuaita, B. H. and O'Riordan, M. X. (2014). Listeria exploits damage and death to spread bad news. Trends Microbiol 22(7): 370-371
6. Bronner, D. N., O'Riordan, M. X. and He, Y. (2013). Caspase-2 mediates a Brucella abortus RB51-induced hybrid cell death having features of apoptosis and pyroptosis. Front Cell Infect Microbiol 3: 83.
7. Sun, Y. and O'Riordan, M. X. (2013). Regulation of bacterial pathogenesis by intestinal short-chain Fatty acids. Adv Appl Microbiol 85: 93-118.
8. Cassidy, S. K. and O'Riordan, M. X. (2013). More than a pore: the cellular response to cholesterol-dependent cytolysins. Toxins (Basel) 5(4): 618-636.
9. Sun, Y., Wilkinson, B. J., Standiford, T. J., Akinbi, H. T. and O'Riordan, M. X. (2012). Fatty acids regulate stress resistance and virulence factor production for Listeria monocytogenes. J Bacteriol 194(19): 5274-5284.
10. Cassidy, S. K., Hagar, J. A., Kanneganti, T. D., Franchi, L., Nunez, G. and O'Riordan, M. X. (2012). Membrane damage during Listeria monocytogenes infection triggers a caspase-7 dependent cytoprotective response. PLoS Pathog 8(7): e1002628.
11. Burkholder, K. M., Perry, J. W., Wobus, C. E., Donato, N. J., Showalter, H. D., Kapuria, V. and O'Riordan, M. X. (2011). A small molecule deubiquitinase inhibitor increases localization of inducible nitric oxide synthase to the macrophage phagosome and enhances bacterial killing. Infect Immun 79(12): 4850-4857.
12. Radtke, A. L., Anderson, K. L., Davis, M. J., DiMagno, M. J., Swanson, J. A. and O'Riordan, M. X. (2011). Listeria monocytogenes exploits cystic fibrosis transmembrane conductance regulator (CFTR) to escape the phagosome. Proc Natl Acad Sci U S A 108(4): 1633-1638.
13. Sun, Y. and O'Riordan, M. X. (2010). Branched-chain fatty acids promote Listeria monocytogenes intracellular infection and virulence. Infect Immun 78(11): 4667-4673.