Education

PhD in BiocPhD in Biochemistry, Tufts University School of Medicine, Boston, MA, USA, 1970

Current position

Professor (Research), Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA

Publications (since 2005)

1. Vences-Catalan, F., Rajapaksa, R., Srivastava, M. K., Marabelle, A., Kuo, C. C., Levy, R. and Levy, S. (2015). Tetraspanin CD81, a modulator of immune suppression in cáncer and metástasis. OncoImmunology.

2. Vences-Catalan, F., Rajapaksa, R., Srivastava, M. K., Marabelle, A., Kuo, C. C., Levy, R. and Levy, S. (2015). Tetraspanin CD81 promotes tumor growth and metastasis by modulating the functions of T regulatory and myeloid-derived suppressor cells. Cancer Res 75(21): 4517-4526.

3. Vences-Catalan, F., Kuo, C. C. and Levy, S. (2015). Role of an arginine-lysine rich motif in maturation and trafficking of CD19. Biochem Biophys Res Commun 465(3): 319-323.

4. Martinez del Hoyo, G., Ramirez-Huesca, M., Levy, S., Boucheix, C., Rubinstein, E., Minguito de la Escalera, M., Gonzalez-Cintado, L., Ardavin, C., Veiga, E., Yanez-Mo, M. and Sanchez-Madrid, F. (2015). CD81 controls immunity to Listeria infection through rac-dependent inhibition of proinflammatory mediator release and activation of cytotoxic T cells. J Immunol 194(12): 6090-6101.

5. Vences-Catalan, F., Kuo, C. C., Sagi, Y., Chen, H., Kela-Madar, N., van Zelm, M. C., van Dongen, J. J. and Levy, S. (2015). A mutation in the human tetraspanin CD81 gene is expressed as a truncated protein but does not enable CD19 maturation and cell surface expression. J Clin Immunol 35(3): 254-263.

6. Al Olaby, R. R., Cocquerel, L., Zemla, A., Saas, L., Dubuisson, J., Vielmetter, J., Marcotrigiano, J., Khan, A. G., Vences Catalan, F., Perryman, A. L., Freundlich, J. S., Forli, S., Levy, S., Balhorn, R. and Azzazy, H. M. (2014). Identification of a novel drug lead that inhibits HCV infection and cell-to-cell transmission by targeting the HCV E2 glycoprotein. PLoS One 9(10): e111333.

7. Ng, P. P., Kuo, C. C., Wang, S., Einav, S., Arcaini, L., Paulli, M., Portlock, C. S., Marcotrigiano, J., Tarr, A., Ball, J., Levy, R. and Levy, S. (2014). B-cell receptors expressed by lymphomas of hepatitis C virus (HCV)-infected patients rarely react with the viral proteins. Blood 123(10): 1512-1515.

8. Sachen, K. L., Strohman, M. J., Singletary, J., Alizadeh, A. A., Kattah, N. H., Lossos, C., Mellins, E. D., Levy, S. and Levy, R. (2012). Self-antigen recognition by follicular lymphoma B-cell receptors. Blood 120(20): 4182-4190.

9. Ng, P. P., Jia, M., Patel, K. G., Brody, J. D., Swartz, J. R., Levy, S. and Levy, R. (2012). A vaccine directed to B cells and produced by cell-free protein synthesis generates potent antilymphoma immunity. Proc Natl Acad Sci U S A 109(36): 14526-14531.

10. Vences-Catalan, F., Rajapaksa, R., Levy, S. and Santos-Argumedo, L. (2012). The CD19/CD81 complex physically interacts with CD38 but is not required to induce proliferation in mouse B lymphocytes. Immunology 137(1): 48-55.

11. Sagi, Y., Landrigan, A., Levy, R. and Levy, S. (2012). Complementary costimulation of human T-cell subpopulations by cluster of differentiation 28 (CD28) and CD81. Proc Natl Acad Sci U S A 109(5): 1613-1618.

12. Bari, R., Guo, Q., Xia, B., Zhang, Y. H., Giesert, E. E., Levy, S., Zheng, J. J. and Zhang, X. A. (2011). Tetraspanins regulate the protrusive activities of cell membrane. Biochem Biophys Res Commun 415(4): 619-626.

13. Quast, T., Eppler, F., Semmling, V., Schild, C., Homsi, Y., Levy, S., Lang, T., Kurts, C. and Kolanus, W. (2011). CD81 is essential for the formation of membrane protrusions and regulates Rac1-activation in adhesion-dependent immune cell migration. Blood 118(7): 1818-1827.

14. Patel, K. G., Ng, P. P., Levy, S., Levy, R. and Swartz, J. R. (2011). Escherichia coli-based production of a tumor idiotype antibody fragment--tetanus toxin fragment C fusion protein vaccine for B cell lymphoma. Protein Expr Purif 75(1): 15-20.

15. Goldstein, M. J., Varghese, B., Brody, J. D., Rajapaksa, R., Kohrt, H., Czerwinski, D. K., Levy, S. and Levy, R. (2011). A CpG-loaded tumor cell vaccine induces antitumor CD4+ T cells that are effective in adoptive therapy for large and established tumors. Blood 117(1): 118-127.

16. Van Zelm, M., Smet, J., Adams, B., Mascart, F., Schandene, L., Janssen, F., Ferster, A., Kuo, C. C., Levy, S., van Dongen, J. and van der Burg, M. (2010). CD81 Gene Defect in an Antibody-deficient Patient Disrupts CD19-complex Formation and Impairs Terminal B-cell Differentiation. J Clin Invest. 20:1265-74.

17. Luo, R. F., Zhao, S., Tibshirani, R., Myklebust, J. H., Sanyal, M., Fernandez, R., Gratzinger, D., Marinelli, R. J., Lu, Z. S., Wong, A., Levy, R., Levy, S. and Natkunam, Y. (2010). CD81 protein is expressed at high levels in normal germinal center B cells and in subtypes of human lymphomas. Hum Pathol 41(2): 271-280.

18. Patel, K. G., Ng, P. P., Kuo, C. C., Levy, S., Levy, R. and Swartz, J. R. (2009). Cell-free production of Gaussia princeps luciferase--antibody fragment bioconjugates for ex vivo detection of tumor cells. Biochem Biophys Res Commun 390(3): 971-976.

19. Varghese, B., Widman, A., Do, J., Taidi, B., Czerwinski, D. K., Timmerman, J., Levy, S. and Levy, R. (2009). Generation of CD8+ T cell-mediated immunity against idiotype-negative lymphoma escapees. Blood 114(20): 4477-4485.

20. Sanyal, M., Fernandez, R. and Levy, S. (2009). Enhanced B cell activation in the absence of CD81. Int Immunol 21(11): 1225-1237.

21. Mani, M., Venkatasubrahmanyam, S., Sanyal, M., Levy, S., Butte, A., Weinberg, K. and Jahn, T. (2009). Wiskott-Aldrich syndrome protein is an effector of Kit signaling. Blood 114(14): 2900-2908.

22. Coffey, G. P., Rajapaksa, R., Liu, R., Sharpe, O., Kuo, C. C., Krauss, S. W., Sagi, Y., Davis, R. E., Staudt, L. M., Sharman, J. P., Robinson, W. H. and Levy, S. (2009). Engagement of CD81 induces ezrin tyrosine phosphorylation and its cellular redistribution with filamentous actin. J Cell Sci 122(Pt 17): 3137-3144.

23. Rocha-Perugini, V., Montpellier, C., Delgrange, D., Wychowski, C., Helle, F., Pillez, A., Drobecq, H., Le Naour, F., Charrin, S., Levy, S., Rubinstein, E., Dubuisson, J. and Cocquerel, L. (2008). The CD81 partner EWI-2wint inhibits hepatitis C virus entry. PLoS One 3(4): e1866.

24. Kanter, G., Yang, J., Voloshin, A., Levy, S., Swartz, J. R. and Levy, R. (2007). Cell-free production of scFv fusion proteins: an efficient approach for personalized lymphoma vaccines. Blood 109(8): 3393-3399.

25. Silvie, O., Greco, C., Franetich, J. F., Dubart-Kupperschmitt, A., Hannoun, L., van Gemert, G. J., Sauerwein, R. W., Levy, S., Boucheix, C., Rubinstein, E. and Mazier, D. (2006). Expression of human CD81 differently affects host cell susceptibility to malaria sporozoites depending on the Plasmodium species. Cell Microbiol 8(7): 1134-1146.

26. Shoham, T., Rajapaksa, R., Kuo, C. C., Haimovich, J. and Levy, S. (2006). Building of the tetraspanin web: distinct structural domains of CD81 function in different cellular compartments. Mol Cell Biol 26(4): 1373-1385.

27. Rubinstein, E., Ziyyat, A., Prenant, M., Wrobel, E., Wolf, J. P., Levy, S., Le Naour, F. and Boucheix, C. (2006). Reduced fertility of female mice lacking CD81. Dev Biol 290(2): 351-358.

28. Cariappa, A., Shoham, T., Liu, H., Levy, S., Boucheix, C. and Pillai, S. (2005). The CD9 tetraspanin is not required for the development of peripheral B cells or for humoral immunity. J Immunol 175(5): 2925-2930.

29. Nakajima, H., Cocquerel, L., Kiyokawa, N., Fujimoto, J. and Levy, S. (2005). Kinetics of HCV envelope proteins' interaction with CD81 large extracellular loop. Biochem Biophys Res Commun 328(4): 1091-1100.

30. Natkunam, Y., Lossos, I. S., Taidi, B., Zhao, S., Lu, X., Ding, F., Hammer, A. S., Marafioti, T., Byrne, G. E., Jr., Levy, S., Warnke, R. A. and Levy, R. (2005). Expression of the human germinal center-associated lymphoma (HGAL) protein, a new marker of germinal center B-cell derivation. Blood 105(10): 3979-3986.