Doriana Fruci
  • Bambino Gesù Children Hospital, Italy
  • Immunology
Personal information


PhD Medical Genetics (PhD equivalent)

Current position

Senior Researcher, Department of Oncohaematology, Bambino Gesù Children Hospital, Rome, Italy

Publications (since 2010)

  1. Petroni, M., Sardina, F., Heil, C., Sahun-Roncero, M., Colicchia, V., Veschi, V., Albini, S., Fruci, D., Ricci, B., Soriani, A., Di Marcotullio, L., Screpanti, I., Gulino, A. and Giannini, G. (2016). The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress. Cell Death Differ 23(2): 197-206.

  2. Mina, M., Boldrini, R., Citti, A., Romania, P., D'Alicandro, V., De Ioris, M., Castellano, A., Furlanello, C., Locatelli, F. and Fruci, D. (2015). Tumor-infiltrating T lymphocytes improve clinical outcome of therapy-resistant neuroblastoma. Oncoimmunology 4(9): e1019981.

  3. Cifaldi, L., Romania, P., Falco, M., Lorenzi, S., Meazza, R., Petrini, S., Andreani, M., Pende, D., Locatelli, F. and Fruci, D. (2015). ERAP1 regulates natural killer cell function by controlling the engagement of inhibitory receptors. Cancer Res 75(5): 824-834.

  4. Stratikos, E., Stamogiannos, A., Zervoudi, E. and Fruci, D. (2014). A role for naturally occurring alleles of endoplasmic reticulum aminopeptidases in tumor immunity and cancer pre-disposition. Front Oncol 4: 363.

  5. Fruci, D., Romania, P., D'Alicandro, V. and Locatelli, F. (2014). Endoplasmic reticulum aminopeptidase 1 function and its pathogenic role in regulating innate and adaptive immunity in cancer and major histocompatibility complex class I-associated autoimmune diseases. Tissue Antigens 84(2): 177-186.

  6. Romania, P., Castellano, A., Surace, C., Citti, A., De Ioris, M. A., Sirleto, P., De Mariano, M., Longo, L., Boldrini, R., Angioni, A., Locatelli, F. and Fruci, D. (2013). High-resolution array CGH profiling identifies Na/K transporting ATPase interacting 2 (NKAIN2) as a predisposing candidate gene in neuroblastoma. PLoS One 8(10): e78481.

  7. Alisi, A., Cho, W. C., Locatelli, F. and Fruci, D. (2013). Multidrug resistance and cancer stem cells in neuroblastoma and hepatoblastoma. Int J Mol Sci 14(12): 24706-24725.

  8. Fruci, D., Lo Monaco, E., Cifaldi, L., Locatelli, F., Tremante, E., Benevolo, M. and Giacomini, P. (2013). T and NK cells: two sides of tumor immunoevasion. J Transl Med 11: 30.

  9. Romania, P., Bertaina, A., Bracaglia, G., Locatelli, F., Fruci, D. and Rota, R. (2012). Epigenetic deregulation of microRNAs in rhabdomyosarcoma and neuroblastoma and translational perspectives. Int J Mol Sci 13(12): 16554-16579.

  10. Lorenzi, S., Forloni, M., Cifaldi, L., Antonucci, C., Citti, A., Boldrini, R., Pezzullo, M., Castellano, A., Russo, V., van der Bruggen, P., Giacomini, P., Locatelli, F. and Fruci, D. (2012). IRF1 and NF-kB restore MHC class I-restricted tumor antigen processing and presentation to cytotoxic T cells in aggressive neuroblastoma. PLoS One 7(10): e46928.

  11. Cifaldi, L., Romania, P., Lorenzi, S., Locatelli, F. and Fruci, D. (2012). Role of endoplasmic reticulum aminopeptidases in health and disease: from infection to cancer. Int J Mol Sci 13(7): 8338-8352.

  12. Fruci, D., Locatelli, F. and Cifaldi, L. (2012). ERAAP modulation: A possible novel strategy for cancer immunotherapy? Oncoimmunology 1(1): 81-82.

  13. Fierabracci, A., Milillo, A., Locatelli, F. and Fruci, D. (2012). The putative role of endoplasmic reticulum aminopeptidases in autoimmunity: insights from genomic-wide association studies. Autoimmun Rev 12(2): 281-288.

  14. Pazzaglia, S., Cifaldi, L., Saran, A., Nobili, V., Fruci, D. and Alisi, A. (2012). Hedgehog/hyaluronic acid interaction network in nonalcoholic fatty liver disease, fibrosis, and hepatocellular carcinoma. Hepatology 56(4): 1589.

  15. Citti, A., Boldrini, R., Inserra, A., Alisi, A., Pessolano, R., Mastronuzzi, A., Zin, A., De Sio, L., Rosolen, A., Locatelli, F. and Fruci, D. (2012). Expression of multidrug resistance-associated proteins in paediatric soft tissue sarcomas before and after chemotherapy. Int J Oncol 41(1): 117-124.

  16. Fruci, D., Benevolo, M., Cifaldi, L., Lorenzi, S., Lo Monaco, E., Tremante, E. and Giacomini, P. (2012). Major histocompatibility complex class i and tumour immuno-evasion: how to fool T cells and natural killer cells at one time. Curr Oncol 19(1): 39-41.

  17. Alisi, A., Romania, P., Nobili, V., Locatelli, F. and Fruci, D. (2011). Human hepatic stellate cells are liver-resident antigen-presenting cells. Hepatology 54(3): 1107.

  18. Cifaldi, L., Lo Monaco, E., Forloni, M., Giorda, E., Lorenzi, S., Petrini, S., Tremante, E., Pende, D., Locatelli, F., Giacomini, P. and Fruci, D. (2011). Natural killer cells efficiently reject lymphoma silenced for the endoplasmic reticulum aminopeptidase associated with antigen processing. Cancer Res 71(5): 1597-1606.

  19. Forloni, M., Albini, S., Limongi, M. Z., Cifaldi, L., Boldrini, R., Nicotra, M. R., Giannini, G., Natali, P. G., Giacomini, P. and Fruci, D. (2010). NF-kappaB, and not MYCN, regulates MHC class I and endoplasmic reticulum aminopeptidases in human neuroblastoma cells. Cancer Res 70(3): 916-924.

  20. Lo Monaco, E., Tremante, E., Cifaldi, L., Fruci, D. and Giacomini, P. (2010). HLA-E and the origin of immunogenic self HLA epitopes. Mol Immunol 47(9): 1661-1662; author reply 1163-1664.