Education

PhD Medical Genetics (PhD equivalent)

Current position

Senior Researcher, Department of Oncohaematology, Bambino Gesù Children Hospital, Rome, Italy

Publications (since 2010)

1. Petroni, M., Sardina, F., Heil, C., Sahun-Roncero, M., Colicchia, V., Veschi, V., Albini, S., Fruci, D., Ricci, B., Soriani, A., Di Marcotullio, L., Screpanti, I., Gulino, A. and Giannini, G. (2016). The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress. Cell Death Differ 23(2): 197-206.

2. Mina, M., Boldrini, R., Citti, A., Romania, P., D'Alicandro, V., De Ioris, M., Castellano, A., Furlanello, C., Locatelli, F. and Fruci, D. (2015). Tumor-infiltrating T lymphocytes improve clinical outcome of therapy-resistant neuroblastoma. Oncoimmunology 4(9): e1019981.

3. Cifaldi, L., Romania, P., Falco, M., Lorenzi, S., Meazza, R., Petrini, S., Andreani, M., Pende, D., Locatelli, F. and Fruci, D. (2015). ERAP1 regulates natural killer cell function by controlling the engagement of inhibitory receptors. Cancer Res 75(5): 824-834.

4. Stratikos, E., Stamogiannos, A., Zervoudi, E. and Fruci, D. (2014). A role for naturally occurring alleles of endoplasmic reticulum aminopeptidases in tumor immunity and cancer pre-disposition. Front Oncol 4: 363.

5. Fruci, D., Romania, P., D'Alicandro, V. and Locatelli, F. (2014). Endoplasmic reticulum aminopeptidase 1 function and its pathogenic role in regulating innate and adaptive immunity in cancer and major histocompatibility complex class I-associated autoimmune diseases. Tissue Antigens 84(2): 177-186.

6. Romania, P., Castellano, A., Surace, C., Citti, A., De Ioris, M. A., Sirleto, P., De Mariano, M., Longo, L., Boldrini, R., Angioni, A., Locatelli, F. and Fruci, D. (2013). High-resolution array CGH profiling identifies Na/K transporting ATPase interacting 2 (NKAIN2) as a predisposing candidate gene in neuroblastoma. PLoS One 8(10): e78481.

7. Alisi, A., Cho, W. C., Locatelli, F. and Fruci, D. (2013). Multidrug resistance and cancer stem cells in neuroblastoma and hepatoblastoma. Int J Mol Sci 14(12): 24706-24725.

8. Fruci, D., Lo Monaco, E., Cifaldi, L., Locatelli, F., Tremante, E., Benevolo, M. and Giacomini, P. (2013). T and NK cells: two sides of tumor immunoevasion. J Transl Med 11: 30.

9. Romania, P., Bertaina, A., Bracaglia, G., Locatelli, F., Fruci, D. and Rota, R. (2012). Epigenetic deregulation of microRNAs in rhabdomyosarcoma and neuroblastoma and translational perspectives. Int J Mol Sci 13(12): 16554-16579.

10. Lorenzi, S., Forloni, M., Cifaldi, L., Antonucci, C., Citti, A., Boldrini, R., Pezzullo, M., Castellano, A., Russo, V., van der Bruggen, P., Giacomini, P., Locatelli, F. and Fruci, D. (2012). IRF1 and NF-kB restore MHC class I-restricted tumor antigen processing and presentation to cytotoxic T cells in aggressive neuroblastoma. PLoS One 7(10): e46928.

11. Cifaldi, L., Romania, P., Lorenzi, S., Locatelli, F. and Fruci, D. (2012). Role of endoplasmic reticulum aminopeptidases in health and disease: from infection to cancer. Int J Mol Sci 13(7): 8338-8352.

12. Fruci, D., Locatelli, F. and Cifaldi, L. (2012). ERAAP modulation: A possible novel strategy for cancer immunotherapy? Oncoimmunology 1(1): 81-82.

13. Fierabracci, A., Milillo, A., Locatelli, F. and Fruci, D. (2012). The putative role of endoplasmic reticulum aminopeptidases in autoimmunity: insights from genomic-wide association studies. Autoimmun Rev 12(2): 281-288.

14. Pazzaglia, S., Cifaldi, L., Saran, A., Nobili, V., Fruci, D. and Alisi, A. (2012). Hedgehog/hyaluronic acid interaction network in nonalcoholic fatty liver disease, fibrosis, and hepatocellular carcinoma. Hepatology 56(4): 1589.

15. Citti, A., Boldrini, R., Inserra, A., Alisi, A., Pessolano, R., Mastronuzzi, A., Zin, A., De Sio, L., Rosolen, A., Locatelli, F. and Fruci, D. (2012). Expression of multidrug resistance-associated proteins in paediatric soft tissue sarcomas before and after chemotherapy. Int J Oncol 41(1): 117-124.

16. Fruci, D., Benevolo, M., Cifaldi, L., Lorenzi, S., Lo Monaco, E., Tremante, E. and Giacomini, P. (2012). Major histocompatibility complex class i and tumour immuno-evasion: how to fool T cells and natural killer cells at one time. Curr Oncol 19(1): 39-41.

17. Alisi, A., Romania, P., Nobili, V., Locatelli, F. and Fruci, D. (2011). Human hepatic stellate cells are liver-resident antigen-presenting cells. Hepatology 54(3): 1107.

18. Cifaldi, L., Lo Monaco, E., Forloni, M., Giorda, E., Lorenzi, S., Petrini, S., Tremante, E., Pende, D., Locatelli, F., Giacomini, P. and Fruci, D. (2011). Natural killer cells efficiently reject lymphoma silenced for the endoplasmic reticulum aminopeptidase associated with antigen processing. Cancer Res 71(5): 1597-1606.

19. Forloni, M., Albini, S., Limongi, M. Z., Cifaldi, L., Boldrini, R., Nicotra, M. R., Giannini, G., Natali, P. G., Giacomini, P. and Fruci, D. (2010). NF-kappaB, and not MYCN, regulates MHC class I and endoplasmic reticulum aminopeptidases in human neuroblastoma cells. Cancer Res 70(3): 916-924.

20. Lo Monaco, E., Tremante, E., Cifaldi, L., Fruci, D. and Giacomini, P. (2010). HLA-E and the origin of immunogenic self HLA epitopes. Mol Immunol 47(9): 1661-1662; author reply 1163-1664.