Dan R. Littman
  • The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, USA
  • Cell biology


M.D. in Molecular Biology, Washington University, St. Louis, MO, 1980

Current position

Professor of Molecular Immunology, Departments of Pathology and Microbiology, New York University School of Medicine
Investigator, Howard Hughes Medical Institute
Coordinator, Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine

Publications (selected)

  1. Menager, M. M. and Littman, D. R. (2016). Actin Dynamics Regulates Dendritic Cell-Mediated Transfer of HIV-1 to T Cells. Cell 164(4): 695-709.

  2. Huang, W., Thomas, B., Flynn, R. A., Gavzy, S. J., Wu, L., Kim, S. V., Hall, J. A., Miraldi, E. R., Ng, C. P., Rigo, F., Meadows, S., Montoya, N. R., Herrera, N. G., Domingos, A. I., Rastinejad, F., Myers, R. M., Fuller-Pace, F. V., Bonneau, R., Chang, H. Y., Acuto, O. and Littman, D. R. (2015). DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions. Nature 528(7583): 517-522.

  3. Sellars, M., Huh, J. R., Day, K., Issuree, P. D., Galan, C., Gobeil, S., Absher, D., Green, M. R. and Littman, D. R. (2015). Regulation of DNA methylation dictates Cd4 expression during the development of helper and cytotoxic T cell lineages. Nat Immunol 16(7): 746-754.

  4. Ciofani, M., Madar, A., Galan, C., Sellars, M., Mace, K., Pauli, F., Agarwal, A., Huang, W., Parkhurst, C. N., Muratet, M., Newberry, K. M., Meadows, S., Greenfield, A., Yang, Y., Jain, P., Kirigin, F. K., Birchmeier, C., Wagner, E. F., Murphy, K. M., Myers, R. M., Bonneau, R. and Littman, D. R. (2012). A validated regulatory network for Th17 cell specification. Cell 151(2): 289-303.

  5. Manel, N., Hogstad, B., Wang, Y., Levy, D. E., Unutmaz, D. and Littman, D. R. (2010). A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature 467(7312): 214-217.

  6. Egawa, T. and Littman, D. R. (2008). ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage. Nat Immunol 9(10): 1131-1139.

  7. Ivanov, II, McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J. and Littman, D. R. (2006). The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126(6): 1121-1133.

  8. Taniuchi, I., Osato, M., Egawa, T., Sunshine, M. J., Bae, S. C., Komori, T., Ito, Y. and Littman, D. R. (2002). Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell 111(5): 621-633.

  9. Sun, Z., Unutmaz, D., Zou, Y. R., Sunshine, M. J., Pierani, A., Brenner-Morton, S., Mebius, R. E. and Littman, D. R. (2000). Requirement for RORgamma in thymocyte survival and lymphoid organ development. Science 288(5475): 2369-2373.

  10. Deng, H., Liu, R., Ellmeier, W., Choe, S., Unutmaz, D., Burkhart, M., Di Marzio, P., Marmon, S., Sutton, R. E., Hill, C. M., Davis, C. B., Peiper, S. C., Schall, T. J., Littman, D. R. and Landau, N. R. (1996). Identification of a major co-receptor for primary isolates of HIV-1. Nature 381(6584): 661-666.

  11. Sawada, S., Scarborough, J. D., Killeen, N. and Littman, D. R. (1994). A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development. Cell 77(6): 917-929.

  12. Killeen, N. and Littman, D. R. (1993). Helper T-cell development in the absence of CD4-p56lck association. Nature 364(6439): 729-732.

  13. Killeen, N., Moriarty, A., Teh, H. S. and Littman, D. R. (1992). Requirement for CD8-major histocompatibility complex class I interaction in positive and negative selection of developing T cells. J Exp Med 176(1): 89-97.

  14. Turner, J. M., Brodsky, M. H., Irving, B. A., Levin, S. D., Perlmutter, R. M. and Littman, D. R. (1990). Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs. Cell 60(5): 755-765.

  15. Norment, A. M., Salter, R. D., Parham, P., Engelhard, V. H. and Littman, D. R. (1988). Cell-cell adhesion mediated by CD8 and MHC class I molecules. Nature 336(6194): 79-81.

  16. Landau, N. R., Warton, M. and Littman, D. R. (1988). The envelope glycoprotein of the human immunodeficiency virus binds to the immunoglobulin-like domain of CD4. Nature 334(6178): 159-162.