Beth Mann
  • Department of Infectious Diseases, St Jude Children’s Research Hospital, USA
  • Microbiology


B.S in Biology, Rhodes College, Memphis, TN, 1995

Current Position

Associate Scientist, Dept of Infectious Disease, Elaine Tuomanen laboratory


  1. Humann, J., Mann, B., Gao, G., Moresco, P., Ramahi, J., Loh, L. N., Farr, A., Hu, Y., Durick-Eder, K., Fillon, S. A., Smeyne, R. J. and Tuomanen, E. I. (2016). Bacterial Peptidoglycan Traverses the Placenta to Induce Fetal Neuroproliferation and Aberrant Postnatal Behavior. Cell Host Microbe 19(6): 901.
  2. Kietzman, C. C., Gao, G., Mann, B., Myers, L. and Tuomanen, E. I. (2016). Dynamic capsule restructuring by the main pneumococcal autolysin LytA in response to the epithelium. Nat Commun 7: 10859.
  3. Brown, L. R., Gunnell, S. M., Cassella, A. N., Keller, L. E., Scherkenbach, L. A., Mann, B., Brown, M. W., Hill, R., Fitzkee, N. C., Rosch, J. W., Tuomanen, E. I. and Thornton, J. A. (2016). AdcAII of Streptococcus pneumoniae Affects Pneumococcal Invasiveness. PLoS One 11(1): e0146785.
  4. Chen, A., Mann, B., Gao, G., Heath, R., King, J., Maissoneuve, J., Alderson, M., Tate, A., Hollingshead, S. K., Tweten, R. K., Briles, D. E., Tuomanen, E. I. and Paton, J. C. (2015). Multivalent Pneumococcal Protein Vaccines Comprising Pneumolysoid with Epitopes/Fragments of CbpA and/or PspA Elicit Strong and Broad Protection. Clin Vaccine Immunol 22(10): 1079-1089.
  5. Johnson, M. D., Kehl-Fie, T. E., Klein, R., Kelly, J., Burnham, C., Mann, B. and Rosch, J. W. (2015). Role of copper efflux in pneumococcal pathogenesis and resistance to macrophage-mediated immune clearance. Infect Immun 83(4): 1684-1694.
  6. Brown, A. O., Mann, B., Gao, G., Hankins, J. S., Humann, J., Giardina, J., Faverio, P., Restrepo, M. I., Halade, G. V., Mortensen, E. M., Lindsey, M. L., Hanes, M., Happel, K. I., Nelson, S., Bagby, G. J., Lorent, J. A., Cardinal, P., Granados, R., Esteban, A., LeSaux, C. J., Tuomanen, E. I. and Orihuela, C. J. (2014). Streptococcus pneumoniae translocates into the myocardium and forms unique microlesions that disrupt cardiac function. PLoS Pathog 10(9): e1004383.
  7. Mann, B., Thornton, J., Heath, R., Wade, K. R., Tweten, R. K., Gao, G., El Kasmi, K., Jordan, J. B., Mitrea, D. M., Kriwacki, R., Maisonneuve, J., Alderson, M. and Tuomanen, E. I. (2014). Broadly protective protein-based pneumococcal vaccine composed of pneumolysin toxoid-CbpA peptide recombinant fusion protein. J Infect Dis 209(7): 1116-1125.
  8. Rosch, J. W., Iverson, A. R., Humann, J., Mann, B., Gao, G., Vogel, P., Mina, M., Murrah, K. A., Perez, A. C., Edward Swords, W., Tuomanen, E. I. and McCullers, J. A. (2014). A live-attenuated pneumococcal vaccine elicits CD4+ T-cell dependent class switching and provides serotype independent protection against acute otitis media. EMBO Mol Med 6(1): 141-154.
  9. Carter, R., Wolf, J., van Opijnen, T., Muller, M., Obert, C., Burnham, C., Mann, B., Li, Y., Hayden, R. T., Pestina, T., Persons, D., Camilli, A., Flynn, P. M., Tuomanen, E. I. and Rosch, J. W. (2014). Genomic analyses of pneumococci from children with sickle cell disease expose host-specific bacterial adaptations and deficits in current interventions. Cell Host Microbe 15(5): 587-599.
  10. Mann, B., van Opijnen, T., Wang, J., Obert, C., Wang, Y. D., Carter, R., McGoldrick, D. J., Ridout, G., Camilli, A., Tuomanen, E. I. and Rosch, J. W. (2012). Control of virulence by small RNAs in Streptococcus pneumoniae. PLoS Pathog 8(7): e1002788.
  11. Orihuela, C. J., Mahdavi, J., Thornton, J., Mann, B., Wooldridge, K. G., Abouseada, N., Oldfield, N. J., Self, T., Ala'Aldeen, D. A. and Tuomanen, E. I. (2009). Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models. J Clin Invest 119(6): 1638-1646.
  12. Rosch, J. W., Mann, B., Thornton, J., Sublett, J. and Tuomanen, E. (2008). Convergence of regulatory networks on the pilus locus of Streptococcus pneumoniae. Infect Immun 76(7): 3187-3196.
  13. Mann, B., Orihuela, C., Antikainen, J., Gao, G., Sublett, J., Korhonen, T. K. and Tuomanen, E. (2006). Multifunctional role of choline binding protein G in pneumococcal pathogenesis. Infect Immun 74(2): 821-829.
  14. Luo, R., Mann, B., Tuomanen, E. and Kriwacki, R. W. (2005). NMR assignment of the R2 domain of pneumococcal choline binding protein A (CbpA). J Biomol NMR 32(1): 93.
  15. Luo, R., Mann, B., Lewis, W. S., Rowe, A., Heath, R., Stewart, M. L., Hamburger, A. E., Sivakolundu, S., Lacy, E. R., Bjorkman, P. J., Tuomanen, E. and Kriwacki, R. W. (2005). Solution structure of choline binding protein A, the major adhesin of Streptococcus pneumoniae. EMBO J 24(1): 34-43.
  16. Gosink, K. K., Mann, E. R., Guglielmo, C., Tuomanen, E. I. and Masure, H. R. (2000). Role of novel choline binding proteins in virulence of Streptococcus pneumoniae. Infect Immun 68(10): 5690-5695.
  17. Hughes, M. T., Matrosovich, M., Rodgers, M. E., McGregor, M. and Kawaoka, Y. (2000). Influenza A viruses lacking sialidase activity can undergo multiple cycles of replication in cell culture, eggs, or mice. J Virol 74(11): 5206-5212.
  18. Kobasa, D., Rodgers, M. E., Wells, K. and Kawaoka, Y. (1997). Neuraminidase hemadsorption activity, conserved in avian influenza A viruses, does not influence viral replication in ducks. J Virol 71(9): 6706-6713.
  19. Karlstrom, A., Heston, S. M., Boyd, K. L., Tuomanen, E. I. and McCullers, J. A. (2011). Toll-like receptor 2 mediates fatal immunopathology in mice during treatment of secondary pneumococcal pneumonia following influenza. J Infect Dis 204(9): 1358-1366.
  20. Takada, A., Robison, C., Goto, H., Sanchez, A., Murti, K. G., Whitt, M. A. and Kawaoka, Y. (1997). A system for functional analysis of Ebola virus glycoprotein. Proc Natl Acad Sci U S A 94(26): 14764-14769.
  21. Goto, H., Bethell, R. C. and Kawaoka, Y. (1997). Mutations affecting the sensitivity of the influenza virus neuraminidase to 4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid. Virology 238(2): 265-272.