Rongwen Xi
  • National Institute of Biological Sciences, China
  • Stem cell


Ph.D in Biology, University of Kentucky, 2002

Current Position

Associate Investigator, National Institute of Biological Sciences, Beijing, China

Publications (since 2008)

  1. Li, X., Yang, F., Chen, H., Deng, B., Li, X. and Xi, R. (2016). Control of germline stem cell differentiation by polycomb and trithorax group genes in the niche microenvironment. Development.
  2. Chen, J., Xu, N., Huang, H., Cai, T. and Xi, R. (2016). A feedback amplification loop between stem cells and their progeny promotes tissue regeneration and tumorigenesis. Elife 5.
  3. Wang, C. and Xi, R. (2015). Keeping intestinal stem cell differentiation on the Tramtrack. Fly (Austin) 9(3): 110-114.
  4. Wang, C., Guo, X., Dou, K., Chen, H. and Xi, R. (2015). Ttk69 acts as a master repressor of enteroendocrine cell specification in Drosophila intestinal stem cell lineages. Development 142(19): 3321-3331.
  5. Yang, F., Zhao, R., Fang, X., Huang, H., Xuan, Y., Ma, Y., Chen, H., Cai, T., Qi, Y. and Xi, R. (2015). The RNA surveillance complex Pelo-Hbs1 is required for transposon silencing in the Drosophila germline. EMBO Rep 16(8): 965-974.
  6. Wang, C., Guo, X. and Xi, R. (2014). EGFR and Notch signaling respectively regulate proliferative activity and multiple cell lineage differentiation of Drosophila gastric stem cells. Cell Res 24(5): 610-627.
  7. Quan, Z., Sun, P., Lin, G. and Xi, R. (2013). TSC1/2 regulates intestinal stem cell maintenance and lineage differentiation through Rheb-TORC1-S6K but independently of nutritional status or Notch regulation. J Cell Sci 126(Pt 17): 3884-3892.
  8. Wang, C., Zhao, R., Huang, P., Yang, F., Quan, Z., Xu, N. and Xi, R. (2013). APC loss-induced intestinal tumorigenesis in Drosophila: Roles of Ras in Wnt signaling activation and tumor progression. Dev Biol 378(2): 122-140.
  9. Lin, G., Zhang, X., Ren, J., Pang, Z., Wang, C., Xu, N. and Xi, R. (2013). Integrin signaling is required for maintenance and proliferation of intestinal stem cells in Drosophila. Dev Biol 377(1): 177-187.
  10. Wen, P., Quan, Z. and Xi, R. (2012). The biological function of the WD40 repeat-containing protein p55/Caf1 in Drosophila. Dev Dyn 241(3): 455-464.
  11. Xu, N., Wang, S. Q., Tan, D., Gao, Y., Lin, G. and Xi, R. (2011). EGFR, Wingless and JAK/STAT signaling cooperatively maintain Drosophila intestinal stem cells. Dev Biol 354(1): 31-43.
  12. Su, Y., Deng, B. and Xi, R. (2011). Polycomb group genes in stem cell self-renewal: a double-edged sword. Epigenetics 6(1): 16-19.
  13. Sun, P., Quan, Z., Zhang, B., Wu, T. and Xi, R. (2010). TSC1/2 tumour suppressor complex maintains Drosophila germline stem cells by preventing differentiation. Development 137(15): 2461-2469.
  14. Wen, P., Sun, P. and Xi, R. (2010). Stem cell niche. In: Gustav, S. (ed.). Regenerative Medicine – From Protocol to Patient. The Springer Press.
  15. Li, X., Han, Y. and Xi, R. (2010). Polycomb group genes Psc and Su(z)2 restrict follicle stem cell self-renewal and extrusion by controlling canonical and noncanonical Wnt signaling. Genes Dev 24(9): 933-946.
  16. Zhao, R. and Xi, R. (2010). Stem cell competition for niche occupancy: emerging themes and mechanisms. Stem Cell Rev 6(3): 345-350.
  17. Lin, G., Xu, N. and Xi, R. (2010). Paracrine unpaired signaling through the JAK/STAT pathway controls self-renewal and lineage differentiation of drosophila intestinal stem cells. J Mol Cell Biol 2(1): 37-49.
  18. Xi, R. (2009). Anchoring stem cells in the niche by cell adhesion molecules. Cell Adh Migr 3(4): 396-401.
  19. Lin, G. and Xi, R. (2008). Intestinal stem cell, muscular niche and Wingless signaling. Fly (Austin) 2(6): 310-312.
  20. Lin, G., Xu, N. and Xi, R. (2008). Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells. Nature 455(7216): 1119-1123.
  21. Zhao, R., Xuan, Y., Li, X. and Xi, R. (2008). Age-related changes of germline stem cell activity, niche signaling activity and egg production in Drosophila. Aging Cell 7(3): 344-354.