Lian Zhou
  • State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, China
  • Microbiology


Ph.D of Microbiology, Institute of Molecular and Cell Biology, National University of Singapore, Singapore, 2010

Current position

Associate Professor, State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China; Zhiyuan Innovative Research Center, Zhiyuan College, Shanghai Jiao Tong University, Shanghai, China

Publications (since 2006)

  1. Zhou, L., Zhang, L. H., Camara, M. and He, Y. W. (2016). The DSF Family of Quorum Sensing Signals: Diversity, Biosynthesis, and Turnover. Trends Microbiol.
  2. Zhou, L., Jiang, H. X., Sun, S., Yang, D. D., Jin, K. M., Zhang, W. and He, Y. W. (2016). Biotechnological potential of a rhizosphere Pseudomonas aeruginosa strain producing phenazine-1-carboxylic acid and phenazine-1-carboxamide. World J Microbiol Biotechnol 32(3): 50.
  3. Wang, X. Y., Zhou, L., Yang, J., Ji, G. H. and He, Y. W. (2016). The RpfB-Dependent Quorum Sensing Signal Turnover System Is Required for Adaptation and Virulence in Rice Bacterial Blight Pathogen Xanthomonas oryzae pv. oryzae. Mol Plant Microbe Interact 29(3): 220-230.
  4. Sun, S., Zhou, L., Jin, K., Jiang, H. and He, Y. W. (2016). Quorum sensing systems differentially regulate the production of phenazine-1-carboxylic acid in the rhizobacterium Pseudomonas aeruginosa PA1201. Sci Rep 6: 30352.
  5. Zhou, L., Wang, X. Y., Sun, S., Yang, L. C., Jiang, B. L. and He, Y. W. (2015). Identification and characterization of naturally occurring DSF-family quorum sensing signal turnover system in the phytopathogen Xanthomonas. Environ Microbiol 17(11): 4646-4658.
  6. Zhou, L., Yu, Y., Chen, X., Diab, A. A., Ruan, L., He, J., Wang, H. and He, Y. W. (2015). The Multiple DSF-family QS Signals are Synthesized from Carbohydrate and Branched-chain Amino Acids via the FAS Elongation Cycle. Sci Rep 5: 13294.
  7. Jin, K., Zhou, L., Jiang, H., Sun, S., Fang, Y., Liu, J., Zhang, X. and He, Y. W. (2015). Engineering the central biosynthetic and secondary metabolic pathways of Pseudomonas aeruginosa strain PA1201 to improve phenazine-1-carboxylic acid production. Metab Eng 32: 30-38.
  8. Wang, J. Y., Zhou, L., Chen, B., Sun, S., Zhang, W., Li, M., Tang, H., Jiang, B. L., Tang, J. L. and He, Y. W. (2015). A functional 4-hydroxybenzoate degradation pathway in the phytopathogen Xanthomonas campestris is required for full pathogenicity. Sci Rep 5: 18456.
  9. Xu, J., Zhou, L., Venturi, V., He, Y. W., Kojima, M., Sakakibari, H., Hofte, M. and De Vleesschauwer, D. (2015). Phytohormone-mediated interkingdom signaling shapes the outcome of rice-Xanthomonas oryzae pv. oryzae interactions. BMC Plant Biol 15: 10.
  10. Zhou, L., Huang, T. W., Wang, J. Y., Sun, S., Chen, G., Poplawsky, A. and He, Y. W. (2013). The rice bacterial pathogen Xanthomonas oryzae pv. oryzae produces 3-hydroxybenzoic acid and 4-hydroxybenzoic acid via XanB2 for use in xanthomonadin, ubiquinone, and exopolysaccharide biosynthesis. Mol Plant Microbe Interact 26(10): 1239-1248.
  11. Zhou, L., Wang, J. Y., Wu, J., Wang, J., Poplawsky, A., Lin, S., Zhu, B., Chang, C., Zhou, T., Zhang, L. H. and He, Y. W. (2013). The diffusible factor synthase XanB2 is a bifunctional chorismatase that links the shikimate pathway to ubiquinone and xanthomonadins biosynthetic pathways. Mol Microbiol 87(1): 80-93.
  12. Wu, D., Lim, S. C., Dong, Y., Wu, J., Tao, F., Zhou, L., Zhang, L. H. and Song, H. (2012). Structural basis of substrate binding specificity revealed by the crystal structures of polyamine receptors SpuD and SpuE from Pseudomonas aeruginosa. J Mol Biol 416(5): 697-712.
  13. Zhou, L., Vorholter, F. J., He, Y. Q., Jiang, B. L., Tang, J. L., Xu, Y., Puhler, A. and He, Y. W. (2011). Gene discovery by genome-wide CDS re-prediction and microarray-based transcriptional analysis in phytopathogen Xanthomonas campestris. BMC Genomics 12: 359.
  14. He, Y. W., Wu, J., Zhou, L., Yang, F., He, Y. Q., Jiang, B. L., Bai, L., Xu, Y., Deng, Z., Tang, J. L. and Zhang, L. H. (2011). Xanthomonas campestris diffusible factor is 3-hydroxybenzoic acid and is associated with xanthomonadin biosynthesis, cell viability, antioxidant activity, and systemic invasion. Mol Plant Microbe Interact 24(8): 948-957.
  15. He, Y. W., Boon, C., Zhou, L. and Zhang, L. H. (2009). Co-regulation of Xanthomonas campestris virulence by quorum sensing and a novel two-component regulatory system RavS/RavR. Mol Microbiol 71(6): 1464-1476.
  16. Zhou, L., Wang, J. and Zhang, L. H. (2007). Modulation of bacterial Type III secretion system by a spermidine transporter dependent signaling pathway. PLoS One 2(12): e1291.
  17. He, Y. W., Wang, C., Zhou, L., Song, H., Dow, J. M. and Zhang, L. H. (2006). Dual signaling functions of the hybrid sensor kinase RpfC of Xanthomonas campestris involve either phosphorelay or receiver domain-protein interaction. J Biol Chem 281(44): 33414-33421.