Michelle N. Wykes
  • QIMR Berghofer Medical Research Institute, Australia
  • Immunology


Ph.D, University of Western Australia, Australia, 1993

Current position

Group Leader, Immunology, QIMR Berghofer Medical Research Institute, Australia


  1. Karunarathne, D. S., Horne-Debets, J. M., Huang, J. X., Faleiro, R., Leow, C. Y., Amante, F., Watkins, T. S., Miles, J. J., Dwyer, P. J., Stacey, K. J., Yarski, M., Poh, C. M., Lee, J. S., Cooper, M. A., Renia, L., Richard, D., McCarthy, J. S., Sharpe, A. H. and Wykes, M. N. (2016). Programmed Death-1 Ligand 2-Mediated Regulation of the PD-L1 to PD-1 Axis Is Essential for Establishing CD4(+) T Cell Immunity. Immunity 45(2): 333-345.
  2. Horne-Debets, J. M., Karunarathne, D. S., Faleiro, R. J., Poh, C. M., Renia, L. and Wykes, M. N. (2016). Mice lacking Programmed cell death-1 show a role for CD8(+) T cells in long-term immunity against blood-stage malaria. Sci Rep 6: 26210.
  3. Panikkar, A., Smith, C., Hislop, A., Tellam, N., Dasari, V., Hogquist, K. A., Wykes, M., Moss, D. J., Rickinson, A., Balfour, H. H., Jr. and Khanna, R. (2015). Cytokine-Mediated Loss of Blood Dendritic Cells During Epstein-Barr Virus-Associated Acute Infectious Mononucleosis: Implication for Immune Dysregulation. J Infect Dis 212(12): 1957-1961.
  4. Panikkar, A., Smith, C., Hislop, A., Tellam, N., Dasari, V., Hogquist, K. A., Wykes, M., Moss, D. J., Rickinson, A., Balfour, H. H., Jr. and Khanna, R. (2015). Impaired Epstein-Barr Virus-Specific Neutralizing Antibody Response during Acute Infectious Mononucleosis Is Coincident with Global B-Cell Dysfunction. J Virol 89(17): 9137-9141.
  5. Wykes, M. N., Horne-Debets, J. M., Leow, C. Y. and Karunarathne, D. S. (2014). Malaria drives T cells to exhaustion. Front Microbiol 5: 249.
  6. Wykes, M. N. (2013). Why haven't we made an efficacious vaccine for malaria? EMBO Rep 14(8): 661.
  7. Pandey, M., Wykes, M. N., Hartas, J., Good, M. F. and Batzloff, M. R. (2013). Long-term antibody memory induced by synthetic peptide vaccination is protective against Streptococcus pyogenes infection and is independent of memory T cell help. J Immunol 190(6): 2692-2701.
  8. Horne-Debets, J. M., Faleiro, R., Karunarathne, D. S., Liu, X. Q., Lineburg, K. E., Poh, C. M., Grotenbreg, G. M., Hill, G. R., MacDonald, K. P., Good, M. F., Renia, L., Ahmed, R., Sharpe, A. H. and Wykes, M. N. (2013). PD-1 dependent exhaustion of CD8+ T cells drives chronic malaria. Cell Rep 5(5): 1204-1213.
  9. Wykes, M. N. and Horne-Debets, J. (2012). Dendritic cells: the Trojan horse of malaria? Int J Parasitol 42(6): 583-587.
  10. Wykes, M. N. (2012). Are plasmacytoid dendritic cells the misguided sentinels of malarial immunity? Trends Parasitol 28(5): 182-186.
  11. Liu, X. Q., Stacey, K. J., Horne-Debets, J. M., Cridland, J. A., Fischer, K., Narum, D., Mackay, F., Pierce, S. K. and Wykes, M. N. (2012). Malaria infection alters the expression of B-cell activating factor resulting in diminished memory antibody responses and survival. Eur J Immunol 42(12): 3291-3301.
  12. Cridland, J. A., Curley, E. Z., Wykes, M. N., Schroder, K., Sweet, M. J., Roberts, T. L., Ragan, M. A., Kassahn, K. S. and Stacey, K. J. (2012). The mammalian PYHIN gene family: phylogeny, evolution and expression. BMC Evol Biol 12: 140.
  13. Wykes, M. N., Kay, J. G., Manderson, A., Liu, X. Q., Brown, D. L., Richard, D. J., Wipasa, J., Jiang, S. H., Jones, M. K., Janse, C. J., Waters, A. P., Pierce, S. K., Miller, L. H., Stow, J. L. and Good, M. F. (2011). Rodent blood-stage Plasmodium survive in dendritic cells that infect naive mice. Proc Natl Acad Sci U S A 108(27): 11205-11210.