Education

PhD, University of New South Wales , Australia, 2009

Current position

Lab Head, Biochemistry and Molecular Biology, Monash University, Australia

Publications

1. Marino, E., Richards, J. L., McLeod, K. H., Stanley, D., Yap, Y. A., Knight, J., McKenzie, C., Kranich, J., Oliveira, A. C., Rossello, F. J., Krishnamurthy, B., Nefzger, C. M., Macia, L., Thorburn, A., Baxter, A. G., Morahan, G., Wong, L. H., Polo, J. M., Moore, R. J., Lockett, T. J., Clarke, J. M., Topping, D. L., Harrison, L. C. and Mackay, C. R. (2017). Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes. Nat Immunol 18(5): 552-562.
2. Tan, J., McKenzie, C., Mariño, E., Macia, L. and Mackay, C. R. (2017). Metabolite-sensing G-protein coupled receptors- facilitators of diet-related immune regulation. Annu Rev Immunol 35: 371-402.
3. Marino, E. (2016). The gut microbiota and immune-regulation: the fate of health and disease. Clin Transl Immunology 5(11): e107.
4. Richards, J. L., Yap, Y. A., McLeod, K. H., Mackay, C. R. and Marino, E. (2016). Dietary metabolites and the gut microbiota: an alternative approach to control inflammatory and autoimmune diseases. Clin Transl Immunology 5(5): e82.
5. Thorburn, A. N., McKenzie, C. I., Shen, S., Stanley, D., Macia, L., Mason, L. J., Roberts, L. K., Wong, C. H., Shim, R., Robert, R., Chevalier, N., Tan, J. K., Marino, E., Moore, R. J., Wong, L., McConville, M. J., Tull, D. L., Wood, L. G., Murphy, V. E., Mattes, J., Gibson, P. G. and Mackay, C. R. (2015). Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat Commun 6: 7320.
6. Macia, L., Tan, J., Vieira, A. T., Leach, K., Stanley, D., Luong, S., Maruya, M., Ian McKenzie, C., Hijikata, A., Wong, C., Binge, L., Thorburn, A. N., Chevalier, N., Ang, C., Marino, E., Robert, R., Offermanns, S., Teixeira, M. M., Moore, R. J., Flavell, R. A., Fagarasan, S. and Mackay, C. R. (2015). Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome. Nat Commun 6: 6734.
7. Marino, E., Walters, S. N., Villanueva, J. E., Richards, J. L., Mackay, C. R. and Grey, S. T. (2014). BAFF regulates activation of self-reactive T cells through B-cell dependent mechanisms and mediates protection in NOD mice. Eur J Immunol 44(4): 983-993.
8. Stolp, J., Marino, E., Batten, M., Sierro, F., Cox, S. L., Grey, S. T. and Silveira, P. A. (2013). Intrinsic molecular factors cause aberrant expansion of the splenic marginal zone B cell population in nonobese diabetic mice. J Immunol 191(1): 97-109.
9. Macia, L., Thorburn, A. N., Binge, L. C., Marino, E., Rogers, K. E., Maslowski, K. M., Vieira, A. T., Kranich, J. and Mackay, C. R. (2012). Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases. Immunol Rev 245(1): 164-176.
10. Marino, E., Tan, B., Binge, L., Mackay, C. R. and Grey, S. T. (2012). B-cell cross-presentation of autologous antigen precipitates diabetes. Diabetes 61(11): 2893-2905.
11. Marino, E. and Grey, S. T. (2012). B cells as effectors and regulators of autoimmunity. Autoimmunity 45(5): 377-387.
12. Marino, E., Silveira, P. A., Stolp, J. and Grey, S. T. (2011). B cell-directed therapies in type 1 diabetes. Trends Immunol 32(6): 287-294.
13. Marino, E., Villanueva, J., Walters, S., Liuwantara, D., Mackay, F. and Grey, S. T. (2009). CD4(+)CD25(+) T-cells control autoimmunity in the absence of B-cells. Diabetes 58(7): 1568-1577.
14. Walters, S., Webster, K. E., Sutherland, A., Gardam, S., Groom, J., Liuwantara, D., Marino, E., Thaxton, J., Weinberg, A., Mackay, F., Brink, R., Sprent, J. and Grey, S. T. (2009). Increased CD4+Foxp3+ T cells in BAFF-transgenic mice suppress T cell effector responses. J Immunol 182(2): 793-801.
15. Marino, E. and Grey, S. T. (2008). A new role for an old player: do B cells unleash the self-reactive CD8+ T cell storm necessary for the development of type 1 diabetes? J Autoimmun 31(3): 301-305.
16. Marino, E., Batten, M., Groom, J., Walters, S., Liuwantara, D., Mackay, F. and Grey, S. T. (2008). Marginal-zone B-cells of nonobese diabetic mice expand with diabetes onset, invade the pancreatic lymph nodes, and present autoantigen to diabetogenic T-cells. Diabetes 57(2): 395-404.
17. Liuwantara, D., Elliot, M., Smith, M. W., Yam, A. O., Walters, S. N., Marino, E., McShea, A. and Grey, S. T. (2006). Nuclear factor-kappaB regulates beta-cell death: a critical role for A20 in beta-cell protection. Diabetes 55(9): 2491-2501.
18. Cardier, J. E., Marino, E., Romano, E., Taylor, P., Liprandi, F., Bosch, N. and Rothman, A. L. (2005). Proinflammatory factors present in sera from patients with acute dengue infection induce activation and apoptosis of human microvascular endothelial cells: possible role of TNF-alpha in endothelial cell damage in dengue. Cytokine 30(6): 359-365.
19. Marino, E. and Cardier, J. E. (2003). Differential effect of IL-18 on endothelial cell apoptosis mediated by TNF-alpha and Fas (CD95). Cytokine 22(5): 142-148.