Nicole Larrieux
  • Laboratory of Molecular & Structural Microbiology, Institut Pasteur de Montevideo, Uruguay, Uruguay,
  • Microbiology


Clinical Biochemist, Universidad de la República, Uruguay, 2007

Current position

Technical Assistant, Laboratory of Molecular & Structural Microbiology, Institut Pasteur de Montevideo, Uruguay


  1. San Martin, F., Mechaly, A. E., Larrieux, N., Wunder, E. A., Jr., Ko, A. I., Picardeau, M., Trajtenberg, F. and Buschiazzo, A. (2017). Crystallization of FcpA from Leptospira, a novel flagellar protein that is essential for pathogenesis. Acta Crystallogr F Struct Biol Commun 73(Pt 3): 123-129.
  2. Trajtenberg, F., Imelio, J. A., Machado, M. R., Larrieux, N., Marti, M. A., Obal, G., Mechaly, A. E. and Buschiazzo, A. (2016). Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action. Elife 5.
  3. Moran-Barrio, J., Lisa, M. N., Larrieux, N., Drusin, S. I., Viale, A. M., Moreno, D. M., Buschiazzo, A. and Vila, A. J. (2016). Crystal Structure of the Metallo-beta-Lactamase GOB in the Periplasmic Dizinc Form Reveals an Unusual Metal Site. Antimicrob Agents Chemother 60(10): 6013-6022.
  4. Obal, G., Trajtenberg, F., Carrion, F., Tome, L., Larrieux, N., Zhang, X., Pritsch, O. and Buschiazzo, A. (2015). STRUCTURAL VIROLOGY. Conformational plasticity of a native retroviral capsid revealed by x-ray crystallography. Science 349(6243): 95-98.
  5. Trajtenberg, F., Albanesi, D., Ruétalo, N., Botti, H., Mechaly, A. E., Nieves, M., Aguilar, P. S., Cybulski, L., Larrieux, N., de Mendoza, D. and Buschiazzo, A. (2014). Allosteric activation of bacterial response regulators: the role of the cognate histidine kinase beyond phosphorylation. MBio 5(6): e02105. 
  6. Trajtenberg, F., Altabe, S., Larrieux, N., Ficarra, F., de Mendoza, D., Buschiazzo, A. and Schujman, G. E. (2014). Structural insights into bacterial resistance to cerulenin. FEBS J 281(10): 2324-2338.
  7. Martinez, A., Peluffo, G., Petruk, A. A., Hugo, M., Pineyro, D., Demicheli, V., Moreno, D. M., Lima, A., Batthyany, C., Duran, R., Robello, C., Marti, M. A., Larrieux, N., Buschiazzo, A., Trujillo, M., Radi, R. and Piacenza, L. (2014). Structural and molecular basis of the peroxynitrite-mediated nitration and inactivation of Trypanosoma cruzi iron-superoxide dismutases (Fe-SODs) A and B: disparate susceptibilities due to the repair of Tyr35 radical by Cys83 in Fe-SODB through intramolecular electron transfer. J Biol Chem 289(18): 12760-12778.
  8. Buschiazzo, A., Muia, R., Larrieux, N., Pitcovsky, T., Mucci, J. and Campetella, O. (2012). Trypanosoma cruzi trans-sialidase in complex with a neutralizing antibody: structure/function studies towards the rational design of inhibitors. PLoS Pathog 8(1): e1002474.
  9. Ortiz, C., Larrieux, N., Medeiros, A., Botti, H., Comini, M. and Buschiazzo, A. (2011). Expression, crystallization and preliminary X-ray crystallographic analysis of glucose-6-phosphate dehydrogenase from the human pathogen Trypanosoma cruzi in complex with substrate. Acta Crystallogr Sect F Struct Biol Cryst Commun 67(Pt 11): 1457-1461.