Jean-Philippe Girard
  • Institut de Pharmacologie et de Biologie Structurale (IPBS) CNRS, Université de Toulouse UPS, France, France,
  • Immunology


PhD in Molecular Biology , University of Toulouse , France, 1992

Current position

1st Class Senior Research Director (DR1) at INSERM, Director of the Institute of Pharmacology and Structural Biology (IPBS), CNRS and University of Toulouse , France


  1. Cayrol, C., Duval, A., Schmitt, P., Roga, S., Camus, M., Stella, A., Burlet-Schiltz, O., Gonzalez-de-Peredo, A. and Girard, J.-P. (2018). Environmental allergens induce allergic inflammation through proteolytic maturation of IL-33. Nature Immunology 19(4): 375-385. 

  2. Liew, F. Y., Girard, J. P. and Turnquist, H. R. (2016). Interleukin-33 in health and disease. Nat Rev Immunol 16(11): 676-689. 

  3. Lefrancais, E., Duval, A., Mirey, E., Roga, S., Espinosa, E., Cayrol, C. and Girard, J. P. (2014). Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells. Proc Natl Acad Sci U S A 111(43): 15502-15507. 

  4. Cayrol, C. and Girard, J. P. (2014). IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy. Curr Opin Immunol 31: 31-37. 

  5. Lefrancais, E., Roga, S., Gautier, V., Gonzalez-de-Peredo, A., Monsarrat, B., Girard, J. P. and Cayrol, C. (2012). IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G. Proc Natl Acad Sci U S A 109(5): 1673-1678. 

  6. Girard, J. P., Moussion, C. and Forster, R. (2012). HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes. Nat Rev Immunol 12(11): 762-773. 

  7. Moussion, C. and Girard, J. P. (2011). Dendritic cells control lymphocyte entry to lymph nodes through high endothelial venules. Nature 479(7374): 542-546. 

  8. Cayrol, C. and Girard, J. P. (2009). The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1. Proc Natl Acad Sci U S A 106(22): 9021-9026. 

  9. Moussion, C., Ortega, N. and Girard, J. P. (2008). The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'? PLoS One 3(10): e3331. 

  10. Carriere, V., Roussel, L., Ortega, N., Lacorre, D. A., Americh, L., Aguilar, L., Bouche, G. and Girard, J. P. (2007). IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo. Proc Natl Acad Sci U S A 104(1): 282-287.