Aftab Nadeem
  • Research fellow, Aftab Nadeem
  • Biochemistry, Cancer Biology, Cell Biology, Microbiology, Molecular Biology


PhD, Lund University, 2016



1. Nadeem A*, Alam T, Eric T, Myint SL, ur Rehman Z, Liu T, Bally M, Arnqvist A, Sjöstdt A, Wang H, Zhu J, Persson K, Uhlin BE, Wai SN* (2021). Phosphatidic acid-mediated binding and internalization of the V. cholerae cytotoxin MakA into host cells.
PLoS Pathogens, doi: 10.1371/journal.ppat.1009414. *co-corresponding author

2. Nadeem A*, Berg A, Pace H, Alam A, Toh E, Åden J, Zlatkov N, Myint SL, Persson K, Gröbner G, Sjöstedt A, Bally M, Barandun J, Uhlin BE*, Wai SN*. Protein-lipid interaction at low pH induces oligomerisation of the MakA cytotoxin from Vibrio cholerae.
bioRxiv, doi: *co-corresponding author

3. Nadeem A*, Nagampalli R*, Eric T, Alam A, Myint SL, Heidler T, Dongre M, Zlatkov N, Pace H, Bano D, Sjöstedt A, Bally M, Uhlin BE, Wai SN and Persson K (2021). A tripartite cytolytic toxin formed by Vibrio cholerae proteins with flagellum-facilitated secretion.
PNAS, doi: *Equal contribution

4. Hansen CF, Nadeem A, Schmidtchen A, van der Plas MJA (2021). Differential internalization of thrombin-derived host defense into monocytes and macrophages.
Journal of Innate Immunity, accepted Manuscript.

5. Nadeem A*, Aung KM*, Ray T, Persson K, Pal A, Uhlin BE and Wai SN (2021). Suppression of β-catenin signaling in colon carcinoma cells by a bacterial protein.
International Journal of Cancer, doi: 10.1002/ijc.33562 *Equal contribution

6. Brisuda A, Ho JCS, Kandiyal PS, Ng JTY, Ambite I, Butler DSC, Hacek J, Wan MLY, Tran TH, Nadeem A, Tran TH, Hastings A, Storm P, Fortunati DL, Esmaeili P, Novotna H, Hornak J, Mu YG, Mok KH, Babjuk M and Svanborg C. (2021). Bladder cancer therapy using a conformationally fluid tumoricidal peptide complex
Nature Communications. doi: 10.1038/s41467-021-23748-y

7. Corkery DP*, Nadeem A*, Aung KM, Hassan A, Liu T, Cervantes R, Lystad AH, Wang H, Persson K, Puhar P, Simonsen A, Uhlin BE, Wai SN and Wu YW. (2020). The Vibrio cholerae cytotoxin MakA induces noncanonical autophagy resulting in the spatial inhibition of canonical autophagy.
Journal of Cell Science. doi: 10.1242/jcs.252015 *Equal contribution

8. Joshi B, Singh B, Nadeem A, Askarian F, Wai SN, Johannessen M and Hegstad K. (2020). Transcriptome profiling of Staphylococcus aureus associated membrane-derived vesicles reveals presence of small RNA-cargo.
Frontiers in Molecular Biosciences. doi: 10.3389/fmolb.2020.566207

9. Nadeem A, Ho JCS, Tran TH, Paul S, Granqvist V, Despretz N and Svanborg C. (2019). Beta-sheet-specific interactions with heat shock proteins define a mechanism of delayed tumor cell death in response to HAMLET.
Journal of Molecular Biology. 431, 2612–2627

10. Ahmad I, Karah N, Nadeem A, Wai SN, Uhlin BE (2019). Analysis of colony phase variation switch in Acinetobacter baumannii clinical isolates.
PLoS One. 4;14(1):e0210082. doi: 10.1371/journal.pone.0210082.

11. Butler DSC, Ambite I, Nagy K, Cafaro C, Ahmed A, Nadeem A, Filenko N, Tran TH, Andersson KE, Wullt B, Puthia M, Svanborg C (2018). Neuroepithelial control of mucosal inflammation in acute cystitis.
Scientific Reports. 2018 Jul 20;8(1):11015. doi: 10.1038/s41598-018-28634-0.

12. Ambite I, Puthia M, Nagy K, Cafaro C, Nadeem A, Rydström G, Zheng Y, Filenko N, Morin P, Butler D, Wullt B, Miethke T, Svanborg C. (2016). Molecular basis of acute cystitis reveals susceptibility genes and immunotherapeutic targets.
PloS Pathogens. 12(10):e1005848.

13. Puthia M, Ambite I, Cafaro C, Butler D, Huang Y, Lutay N, Rydström G, Gullstrand B, Swaminathan B, Nadeem A, Nilsson B, Svanborg C. (2016). IRF7 inhibition prevents destructive innate immunity - a target for non-antibiotic therapy of bacterial infections.
Science Translational Medicine. 8(336):336ra59.

14. Nadeem A, Sanborn J, Gettel DL, Ho JCS, Rydström A, Ngassam VN, Klausen TK, Pedersen SF, Lam M, Parikh AN and Svanborg C (2015). Protein receptor-independent plasma membrane remodeling by HAMLET; a tumoricidal protein-lipid complex.
Scientific Reports. 5:16432. doi: 10.1038/srep16432.

15. Ho JCS*, Nadeem A*, Rydström A, Puthia M and Svanborg C (2015). Targeting of nucleotide-binding proteins by HAMLET - a conserved tumor cell death mechanism.
Oncogene. doi: 10.1038/onc.2015.144. *Equal contribution

16. Ho JCS, Sielaff H, Nadeem A, Svanborg C and Gruber G. The molecular motor F-ATP synthase is targeted by the tumoricidal protein HAMLET (2015).
Journal of Molecular Biology. doi: 10.1016/j.jmb.2015.01.024.

17. Puthia M, Storm P, Nadeem A, Hsiung S, Svanborg C. Prevention and treatment of colon cancer by peroral administration of HAMLET (human α-lactalbumin made lethal to tumour cells) (2013).
Gut. 63(1): 131-142.

18. Lutay N, Ambite I, Grönberg-Hernandez J, Rydström G, Ragnarsdottir B, Puthia M, Nadeem A, Zhang, J, Storm, P, Dobrindt U, Wullt, B and Svanborg C (2013). Bacterial control of host gene expression through RNA polymerase II.
Journal of Clinical Investigation. 123: 2366-79.

19. Nadeem A, Syed Q, Baig S, Irfan M and Nadeem M (2010). Enhanced Production of Citric Acid by Aspergillus niger M-101 using Lower Alcohols.
Turkish Journal of Biochemistry. 35 (1): 7-13.


1. Zlatkov N, Nadeem A, Uhlin BE, Wai SN. Eco-Evolutionary Feedbacks Mediated by Bacterial Membrane Vesicles (2020).
FEMS Microbiol. Rev.

2. Nadeem A, Oscarsson J, Wai SN. Delivery of virulence factors by bacterial membrane vesicles to mammalian host cells (2020). p 131-158. ISBN: 978-3-030-36330-7. doi: 10.1007/978-3-030-36331-4.

3. Ho JCS*, Nadeem A*, Svanborg C. HAMLET – A protein-lipid complex with broad tumoricidal activity (2017).
Biochem Biophys Res Commun. 482(3):454-458. *Equal contribution

4. Ho JCS, Rydström A, Trulsson M, Bålfors J, Storm P, Puthia M, Nadeem A, Svanborg C. HAMLET: functional properties and therapeutic potential. (2012).
Future Oncology. 8(10):1301-13. doi: 10.2217/fon.12.122.

5. Godaly G, Ambite I, Puthia M, Nadeem A, Ho J, Nagy K, Huang Y, Rydström G, Svanborg C (2016). Urinary Tract Infection Molecular Mechanisms and Clinical Translation.


1. Liu Y, Nadeem A, Sebastian S, Olsson M, Styring E, Isaksson H, Tägil M, Lidgren L, Raina DB. Nano-/micro- sized hydroxyapatite moiety improves tumor eradication by synergistic intracellular and extracellular long-term doxorubicin delivery. Manuscript in preparation

2. Farag SI, Francis MK, Nadeem A, Wai SN, Stenlund H, Francis MS. Macrophage innate immune responses delineate between defective translocon assemblies produced by Yersinia pseudotuberculosis YopD mutants. Manuscript Submitted

3. Aung KM*, Nadeem A*, Myint SL, Cervantes R, Bally M, Puhar A, Persson K, Uhlin BE, Wai SN. A novel role of T6SS effector molecule, Tle2VC phospholipase induces autophagy in host cells. Manuscript in preparation. *Equal contribution