Helene Tronchere
  • INSERM U1048 I2MC and Université Paul Sabatier, France
  • Cancer biology


Ph.D, Université Paul Sabatier, Toulouse III, France, 1992

Current position

Senior Researcher, Institute of Cardiovascular and Metabolic Diseases, INSERM, France


  1. Timotin, A., Pisarenko, O., Sidorova, M., Studneva, I., Shulzhenko, V., Palkeeva, M., Serebryakova, L., Molokoedov, A., Veselova, O., Cinato, M., Tronchere, H., Boal, F. and Kunduzova, O. (2017). Myocardial protection from ischemia/reperfusion injury by exogenous galanin fragment. Oncotarget 8(13): 21241-21252.
  2. Akil, A., Peng, J., Omrane, M., Gondeau, C., Desterke, C., Marin, M., Tronchere, H., Taveneau, C., Sar, S., Briolotti, P., Benjelloun, S., Benjouad, A., Maurel, P., Thiers, V., Bressanelli, S., Samuel, D., Brechot, C. and Gassama-Diagne, A. (2016). Septin 9 induces lipid droplets growth by a phosphatidylinositol-5-phosphate and microtubule-dependent mechanism hijacked by HCV. Nat Commun 7: 12203.
  3. Boal, F., Puhar, A., Xuereb, J. M., Kunduzova, O., Sansonetti, P. J., Payrastre, B. and Tronchere, H. (2016). PI5P Triggers ICAM-1 Degradation in Shigella Infected Cells, Thus Dampening Immune Cell Recruitment. Cell Rep 14(4): 750-759.
  4. Boal, F., Timotin, A., Roumegoux, J., Alfarano, C., Calise, D., Anesia, R., Parini, A., Valet, P., Tronchere, H. and Kunduzova, O. (2016). Apelin-13 administration protects against ischaemia/reperfusion-mediated apoptosis through the FoxO1 pathway in high-fat diet-induced obesity. Br J Pharmacol 173(11): 1850-1863.
  5. Mansour, R., Severin, S., Xuereb, J. M., Gratacap, M. P., Laporte, J., Buj-Bello, A., Tronchere, H. and Payrastre, B. (2016). Expression of myotubularins in blood platelets: Characterization and potential diagnostic of X-linked myotubular myopathy. Biochem Biophys Res Commun 476(3): 167-173.
  6. Boal, F., Mansour, R., Gayral, M., Saland, E., Chicanne, G., Xuereb, J. M., Marcellin, M., Burlet-Schiltz, O., Sansonetti, P. J., Payrastre, B. and Tronchere, H. (2015). TOM1 is a PI5P effector involved in the regulation of endosomal maturation. J Cell Sci 128(4): 815-827.
  7. Boal, F., Roumegoux, J., Alfarano, C., Timotin, A., Calise, D., Anesia, R., Drougard, A., Knauf, C., Lagente, C., Roncalli, J., Desmoulin, F., Tronchere, H., Valet, P., Parini, A. and Kunduzova, O. (2015). Apelin regulates FoxO3 translocation to mediate cardioprotective responses to myocardial injury and obesity. Sci Rep 5: 16104.
  8. Payrastre, B., Gaits-Iacovoni, F., Sansonetti, P. and Tronchere, H. (2012). Phosphoinositides and cellular pathogens. Subcell Biochem 59: 363-388.
  9. Viaud, J., Boal, F., Tronchere, H., Gaits-Iacovoni, F. and Payrastre, B. (2014). Phosphatidylinositol 5-phosphate: a nuclear stress lipid and a tuner of membranes and cytoskeleton dynamics. Bioessays 36(3): 260-272.
  10. Puhar, A., Tronchere, H., Payrastre, B., Nhieu, G. T. and Sansonetti, P. J. (2013). A Shigella effector dampens inflammation by regulating epithelial release of danger signal ATP through production of the lipid mediator PtdIns5P. Immunity 39(6): 1121-1131.
  11. Royer, B., Hnia, K., Gavriilidis, C., Tronchere, H., Tosch, V. and Laporte, J. (2013). The myotubularin-amphiphysin 2 complex in membrane tubulation and centronuclear myopathies. EMBO Rep 14(10): 907-915.
  12. Amoasii, L., Bertazzi, D. L., Tronchere, H., Hnia, K., Chicanne, G., Rinaldi, B., Cowling, B. S., Ferry, A., Klaholz, B., Payrastre, B., Laporte, J. and Friant, S. (2012). Phosphatase-dead myotubularin ameliorates X-linked centronuclear myopathy phenotypes in mice. PLoS Genet 8(10): e1002965.
  13. Chicanne, G., Severin, S., Boscheron, C., Terrisse, A. D., Gratacap, M. P., Gaits-Iacovoni, F., Tronchere, H. and Payrastre, B. (2012). A novel mass assay to quantify the bioactive lipid PtdIns3P in various biological samples. Biochem J 447(1): 17-23.
  14. Tronchere, H., Bolino, A., Laporte, J. and Payrastre, B. (2012). Myotubularins and associated neuromuscular diseases. Clin. Lipidol 7.
  15. Colomba, A., Giuriato, S., Dejean, E., Thornber, K., Delsol, G., Tronchere, H., Meggetto, F., Payrastre, B. and Gaits-Iacovoni, F. (2011). Inhibition of Rac controls NPM-ALK-dependent lymphoma development and dissemination. Blood Cancer J 1(6): e21.
  16. Dupuis-Coronas, S., Lagarrigue, F., Ramel, D., Chicanne, G., Saland, E., Gaits-Iacovoni, F., Payrastre, B. and Tronchere, H. (2011). The nucleophosmin-anaplastic lymphoma kinase oncogene interacts, activates, and uses the kinase PIKfyve to increase invasiveness. J Biol Chem 286(37): 32105-32114.
  17. Gratacap, M. P., Guillermet-Guibert, J., Martin, V., Chicanne, G., Tronchere, H., Gaits-Iacovoni, F. and Payrastre, B. (2011). Regulation and roles of PI3Kbeta, a major actor in platelet signaling and functions. Adv Enzyme Regul 51(1): 106-116.
  18. Hnia, K., Tronchere, H., Tomczak, K. K., Amoasii, L., Schultz, P., Beggs, A. H., Payrastre, B., Mandel, J. L. and Laporte, J. (2011). Myotubularin controls desmin intermediate filament architecture and mitochondrial dynamics in human and mouse skeletal muscle. J Clin Invest 121(1): 70-85.
  19. Neukomm, L. J., Nicot, A. S., Kinchen, J. M., Almendinger, J., Pinto, S. M., Zeng, S., Doukoumetzidis, K., Tronchere, H., Payrastre, B., Laporte, J. F. and Hengartner, M. O. (2011). The phosphoinositide phosphatase MTM-1 regulates apoptotic cell corpse clearance through CED-5-CED-12 in C. elegans. Development 138(10): 2003-2014.
  20. Ramel, D., Lagarrigue, F., Pons, V., Mounier, J., Dupuis-Coronas, S., Chicanne, G., Sansonetti, P. J., Gaits-Iacovoni, F., Tronchere, H. and Payrastre, B. (2011). Shigella flexneri infection generates the lipid PI5P to alter endocytosis and prevent termination of EGFR signaling. Sci Signal 4(191): ra61.
  21. Vaccari, I., Dina, G., Tronchere, H., Kaufman, E., Chicanne, G., Cerri, F., Wrabetz, L., Payrastre, B., Quattrini, A., Weisman, L. S., Meisler, M. H. and Bolino, A. (2011). Genetic interaction between MTMR2 and FIG4 phospholipid phosphatases involved in Charcot-Marie-Tooth neuropathies. PLoS Genet 7(10): e1002319.
  22. Guittard, G., Mortier, E., Tronchere, H., Firaguay, G., Gerard, A., Zimmermann, P., Payrastre, B. and Nunes, J. A. (2010). Evidence for a positive role of PtdIns5P in T-cell signal transduction pathways. FEBS Lett 584(11): 2455-2460.
  23. Lagarrigue, F., Dupuis-Coronas, S., Ramel, D., Delsol, G., Tronchere, H., Payrastre, B. and Gaits-Iacovoni, F. (2010). Matrix metalloproteinase-9 is upregulated in nucleophosmin-anaplastic lymphoma kinase-positive anaplastic lymphomas and activated at the cell surface by the chaperone heat shock protein 90 to promote cell invasion. Cancer Res 70(17): 6978-6987.
  24. Guittard, G., Gerard, A., Dupuis-Coronas, S., Tronchere, H., Mortier, E., Favre, C., Olive, D., Zimmermann, P., Payrastre, B. and Nunes, J. A. (2009). Cutting edge: Dok-1 and Dok-2 adaptor molecules are regulated by phosphatidylinositol 5-phosphate production in T cells. J Immunol 182(7): 3974-3978.
  25. Ramel, D., Lagarrigue, F., Dupuis-Coronas, S., Chicanne, G., Leslie, N., Gaits-Iacovoni, F., Payrastre, B. and Tronchere, H. (2009). PtdIns5P protects Akt from dephosphorylation through PP2A inhibition. Biochem Biophys Res Commun 387(1): 127-131.
  26. Rohde, H. M., Tronchere, H., Payrastre, B. and Laporte, J. (2009). Detection of myotubularin phosphatases activity on phosphoinositides in vitro and ex vivo. Methods Mol Biol 462: 265-278.
  27. Coronas, S., Lagarrigue, F., Ramel, D., Chicanne, G., Delsol, G., Payrastre, B. and Tronchere, H. (2008). Elevated levels of PtdIns5P in NPM-ALK transformed cells: implication of PIKfyve. Biochem Biophys Res Commun 372(2): 351-355.
  28. Coronas, S., Ramel, D., Pendaries, C., Gaits-Iacovoni, F., Tronchere, H. and Payrastre, B. (2007). PtdIns5P: a little phosphoinositide with big functions? Biochem Soc Symp (74): 117-128.
  29. Pendaries, C., Tronchere, H., Arbibe, L., Mounier, J., Gozani, O., Cantley, L., Fry, M. J., Gaits-Iacovoni, F., Sansonetti, P. J. and Payrastre, B. (2006). PtdIns5P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection. EMBO J 25(5): 1024-1034.
  30. Tosch, V., Rohde, H. M., Tronchere, H., Zanoteli, E., Monroy, N., Kretz, C., Dondaine, N., Payrastre, B., Mandel, J. L. and Laporte, J. (2006). A novel PtdIns3P and PtdIns(3,5)P2 phosphatase with an inactivating variant in centronuclear myopathy. Hum Mol Genet 15(21): 3098-3106.