Sen Liu
  • Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, China
  • Microbiology


Ph.D (combined masters/doctorate program) in Physical Chemistry, Peking University, China, 2007

Current position

Professor in Biochemistry, College of Medical Science, China Three Gorges University, China


  1. Ai, Y., Yu, L., Tan, X., Chai, X. and Liu, S. (2016). Discovery of Covalent Ligands via Noncovalent Docking by Dissecting Covalent Docking Based on a "Steric-Clashes Alleviating Receptor (SCAR)" Strategy. J Chem Inf Model 56(8): 1563-1575.
  2. Dong, P., Fan, Y., Sun, J., Lv, M., Yi, M., Tan, X. and Liu, S. (2016). A dynamic interaction process between KaiA and KaiC is critical to the cyanobacterial circadian oscillator. Sci Rep 6: 25129.
  3. Shen, P., Li, M., Liu, C., Yang, W., Liu, S. and Yang, C. (2016). Two Sensitive Fluorescent BOPIM Probes with Tunable TICT Character for Low-Level Water Detection in Organic Solvents. J Fluoresc 26(1): 363-369.
  4. Liao, C., Wang, Y., Tan, X., Sun, L. and Liu, S. (2015). Discovery of novel inhibitors of human S-adenosylmethionine decarboxylase based on in silico high-throughput screening and a non-radioactive enzymatic assay. Sci Rep 5: 10754.
  5. Liu, X., Wang, X., Yang, X., Liu, S., Jiang, L., Qu, Y., Hu, L., Ouyang, Q. and Tang, C. (2015). Reliable cell cycle commitment in budding yeast is ensured by signal integration. Elife 4.
  6. Liu, S. and Liu, S. (2015). The Mechanism of KaiB-KaiC Interaction of the Cyanobacterial Circadian Oscillator. Prog Biochem Biophys 42(3): 220-227.
  7. Liu, S., Liu, S., Wang, Y. and Liao, Z. (2014). The P2/P2' sites affect the substrate cleavage of TNF-alpha converting enzyme (TACE). Mol Immunol 62(1): 122-128.
  8. Chen, W., Liu, S. and Liu, S. (2013). Advances in the molecular mechanism of the core circadian oscillator of cyanobacteria. Acta Biophysica Sinica 29(11): 801-810.
  9. Liu, S. and Liu, C. (2013). Identification of a Possible Specific Non-continuous Epitope in Human P2X7 Receptor. Asia Life Sci 22(1): 41-50.
  10. Kapp, G. T., Liu, S., Stein, A., Wong, D. T., Remenyi, A., Yeh, B. J., Fraser, J. S., Taunton, J., Lim, W. A. and Kortemme, T. (2012). Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair. Proc Natl Acad Sci U S A 109(14): 5277-5282.
  11. Liu, S., Liu, S., Zhu, X., Liang, H., Cao, A., Chang, Z. and Lai, L. (2007). Nonnatural protein-protein interaction-pair design by key residues grafting. Proc Natl Acad Sci U S A 104(13): 5330-5335.
  12. Liu, S., Wu, G., Huang, Q., Lai, L., Tang, Y., Unno, H. and Kusunoki, M. (2005). Expression, purification, crystallization and preliminary crystallographic study of a potential metal-dependent hydrolase with cyclase activity from Thermoanaerobacter tengcongensis. Acta Crystallogr Sect F Struct Biol Cryst Commun 61(Pt 1): 90-92.