系统生物学

分类

    Macroscopic Structural and Connectome Mapping of the Mouse Brain Using Diffusion Magnetic Resonance Imaging
    利用弥散磁共振成像绘制小鼠大脑的宏观结构和连接组图
    作者:  Tanzil Mahmud Arefin, Choong Heon Lee, Jordon D. White, Jiangyang ZhangArie Kaffman, 日期: 11/20/2021, 浏览量: 784, Q&A: 0

    Translational work in rodents elucidates basic mechanisms that drive complex behaviors relevant to psychiatric and neurological conditions. Nonetheless, numerous promising studies in rodents later fail in clinical trials, highlighting the need for

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    Histone modification ChIP-seq on Arabidopsis thaliana Plantlets
    拟南芥植株上的组蛋白修饰ChIP-seq
    作者:  Juan S. Ramirez-Prado, David LatrasseMoussa Benhamed, 日期: 11/05/2021, 浏览量: 586, Q&A: 1

    Characterizing the molecular mechanisms regulating gene expression is crucial for understanding the regulatory processes underlying physiological responses to environmental and developmental signals in eukaryotes. The covalent modification of

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    Protocols to Induce, Prevent, and Treat Post-traumatic Stress Disorder-like Memory in Mice: Optogenetics and Behavioral Approaches
    诱导、预防和治疗小鼠创伤后应激障碍样记忆的方案:光遗传学和行为方法

    One of the cardinal features of post-traumatic stress disorder (PTSD) is a paradoxical memory alteration including both emotional hypermnesia for salient trauma-related cues and amnesia for the surrounding traumatic context. Interestingly, some

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    Protocol for RNA-seq Expression Analysis in Yeast
    酵母RNA-seq表达分析方法
    作者:  Stefan Bohn, 日期: 09/20/2021, 浏览量: 781, Q&A: 0

    Genome-wide sequencing of RNA (RNA-seq) has become an inexpensive tool to gain key insights into cellular and disease mechanisms. Sample preparation and sequencing are streamlined and allow the acquisition of hundreds of gene expression profiles in

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    Assessing the in vitro Binding Specificity of Histone Modification Reader Proteins Using Histone Peptide Arrays
    利用组蛋白肽阵列评估组蛋白修饰阅读蛋白的体外结合特异性
    作者:  Mark W. SooArneet L. Saltzman, 日期: 09/20/2021, 浏览量: 526, Q&A: 0

    In the field of chromatin biology, a major goal of understanding the roles of histone post-translational modifications is to identify the proteins and domains that recognize these modifications. Synthetic histone peptides containing one or more

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    Isolation of Nuclei from Mouse Dorsal Root Ganglia for Single-nucleus Genomics
    小鼠背根神经节细胞核的分离及其单核基因组学研究
    作者:  Lite Yang, Ivan Tochitsky, Clifford J. WoolfWilliam Renthal, 日期: 08/05/2021, 浏览量: 980, Q&A: 0

    Primary somatosensory neurons, whose cell bodies reside in the dorsal root ganglion (DRG) and trigeminal ganglion, are specialized to transmit sensory information from the periphery to the central nervous system. Our molecular understanding of

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    反刍动物瘤胃样品采集与保存
    Collection and Preservation of Ruminant Microbial Samples
    作者:  张小丽, 王祚, 周传社, 焦金真谭支良, 日期: 07/07/2021, 浏览量: 303, Q&A: 0
    摘要:反刍动物是农业部提倡养殖的节粮型动物,其瘤胃是自然界最完美的天然发酵罐,具备利用纤维饲料的优势。反刍动物瘤胃的研究不仅是对其营养代谢研究是必要的,对于绿色养殖更是至关重要的。因此采集瘤胃样品及保存是反刍动物相关研究人员必备的操作技术(王祚,2018; Xue ...
    厌氧微生物培养基制备与培养方法
    Preparation of Media and Culturing of Anaerobic Microbes
    作者:  赵圣国, 日期: 07/07/2021, 浏览量: 300, Q&A: 0
    摘要:厌氧微生物生活在无氧的环境中,与需氧微生物相比培养技术特殊。本文介绍了厌氧微生物培养基制备方法,具体营养成分需要根据不同微生物的种类进行选择。